RuyiCai

PhD, Yulong Li Lab, PKU

[RuyiCai @_RuyiCai]

So excited to see our study online on bioRxiv!
I really love this story and hope these beautiful sensors can help the community better understand the eCB system.
Looking forward to seeing what people can do with them! 😎

[Yulong Li Lab @yulonglilab]

A long-standing question in neuroscience is why the eCB system uses two ligands for the same receptors and how their release differs. To address it, we’re happy to share a pair of selective GRAB sensors that detect 2-AG and AEA, respectively, in real time.
https://t.co/wF1H9kmTrB

[RuyiCai @_RuyiCai]

🧠🧠🧠

[Yulong Li Lab @yulonglilab]

(1/7) Far-red dopamine sensor is coming! Excited to introduce our chemigenetic DA sensor, HaloDA1.0! #Dopamine #FarRedSensors, #GRAB https://t.co/hvFwIO6BWh

[RuyiCai @_RuyiCai]

Excited to present my poster on Oct 8, 13: 00-17: 00! Learn about our new endocannabinoid sensors with selective responses to anandamide and 2-AG. ​All are welcome - stop by and chat!​ 🧠🧠

[Yulong Li Lab @yulonglilab]

Hello Chicago! 👋
Li lab is presenting our new findings at #SfN2024. Come and talk with us! @BohanLi_PKU @ TeoWeijian @_RuyiCai @XuelinLi1 🧠🔬

[RuyiCai @_RuyiCai]

👍👍👍

[Yulong Li Lab @yulonglilab]

(1/4) Exciting news! Our new GRAB sensor of SNPF promotes discoveries in the dynamics and molecular regulation between neuropeptide and neurotransmitter release in vivo. ✨✨✨Dive into the details here: https://t.co/EjzLM8N5WK. 🧪 Flies and plasmids are all available NOW!

[Yulong Li Lab @yulonglilab]

Thrilled to announce the publication of our green and red dopamine sensors! Sensitive new tools for in vivo cortical dopamine detection and flexible with dual-color imaging!! Congrats @_echozhuo @robinlou66 and our amazing collaborators who made this possible! #dopamine #GRAB

[Yulong Li Lab @yulonglilab]

We are thrilled to share our latest biological finding published with @NeuroCellPress that "Local 5-HT signaling bi-directionally regulates the coincidence time window for associative learning"!
Big congrats to @BigTree_Zeng, @XuelinLi1!
Check it out
https://t.co/rzAIHNhShQ

[Yulong Li Lab @yulonglilab]

Li Lab is now presenting an e-poster in #ICRS2022GALWAY !
New endocannabinoid sensors in GRAB family. We have successfully developed two new sensors, very selective for AEA and 2-AG, respectively.

[Yulong Li Lab @yulonglilab]

Great work!!

[Yulong Li Lab @yulonglilab]

1/4 New discovery from Yulong Li Lab! We found that 5-HT regulates the coincidence time window of one-trial olfactory learning in both behavior and circuitry plasticity levels. #coincidence time window #olfactory_learning #GRAB_sensors

[Yulong Li Lab @yulonglilab]

1/4 A toolkit of new GRAB fluorescent neuropeptide sensors from Li Lab! These sensors can detect neuropeptides at nanomolar concentration with a robust increase in fluorescence. #GRABSensors #Neuropeptide

[Yulong Li Lab @yulonglilab]

Happy to share our endocannabinoid sensor published on @NatureBiotech today. GRAB-eCB2.0, which is based on CB1R and cpEGFP, enables the detection of eCB in vivo with good sensitivity and spatiotemporal resolution. #GRABSensors #endocannabinoid