leo

[Kun Chen @kunchenguid]

Jev gave me $5 of API credit when i signed up

when i die, i will pass what's left of it to my son

[leo @abhineezy]

@dankrieg do you provision a vps for your users?

[Nikita Bier @nikitabier]

One of the greatest viruses of the modern man is looking at Instagram Stories. You will melt your brain looking at a barrage of outcomes—like vacations, parties, cars—with no visibility of the process that got them there.

[leo @abhineezy]

@GulatiYajat Conversions?

[leo @abhineezy]

@kyanbuilds is the subscribe event on meta immediately available to you? how do you get it immediately available through meta sdk

[leo @abhineezy]

@deivcodes how did you get approved to run ads?

[leo @abhineezy]

@johnappscaler @MaxHirsch13 I’m tryna figure out the same rn

[leo @abhineezy]

@johnappscaler @MaxHirsch13 That’s not true. You need volume to optimize for appsflyer events, the meta SDK events appear to be a shortcut that allow you to optimize immediately

[leo @abhineezy]

@ChadAppDev @simonecanciello how did you get the meta SDK to let you optimize for subscriptions? it’s grey for me for months. do you make the app super cheap to get the volume

[leo @abhineezy]

@600_mbb how did you get the meta SDK to let you optimize for subscriptions? it’s grey for me for months. do you make the app super cheap to get the volume

[leo @abhineezy]

@aureliuscajigas how did you get the meta SDK to let you optimize for subscriptions? it’s grey for me for months. do you make the app super cheap get the volume

[leo @abhineezy]

@thatdadjacob how did you get the meta SDK to let you optimize for subscriptions? it’s grey for me still

[Afshine Emrani MD FACC @afshineemrani]

We just crossed a line in medicine that humanity has been walking toward for a hundred years.
For the first time, doctors can take a biopsy of your specific tumor, read its unique DNA mutations — the exact fingerprint no other cancer on earth shares — and build a custom mRNA blueprint written for one human being. Yours.
It doesn't poison the cancer. It teaches your own immune system what to hunt.
And this week, Phase 3 results confirmed it works.
Added to the best immunotherapy we already had, this individualized cancer vaccine has been dramatically cutting the odds that high-risk melanoma comes back. In the earlier data, the combination reduced the risk of recurrence or death by 49%, and the risk of the cancer spreading to distant organs by 62%, compared to the standard treatment alone. This week's Phase 3 readout confirmed the benefit holds. That is not a modest tweak. That is a different trajectory for a human life.
And melanoma is just the first door. The same approach is now in trials across lung, bladder, and kidney cancers — a whole program of them, racing forward.
Understand what this actually means, because it's bigger than one drug.
For all of history, we fought cancer with blunt weapons. Cut it out. Burn it with radiation. Flood the whole body with chemotherapy and hope the cancer dies before the patient suffers too much. We were swinging a hammer in the dark.
This is a blueprint. A weapon designed atom by atom for one person's disease, that turns their own body into the thing that finds and destroys it. We are watching medicine shift from managing cancer to hunting it.
I've spent my life as a physician, and I did not expect to see this so soon. We were told personalized cancer vaccines were a thirty-year dream. They are happening right now, in real patients, with real data, in our lifetime.
I don't say this lightly, and I say it as a doctor who knows exactly how rare these moments are: this is one of the most hopeful things to happen in the history of the field.
I woke up thinking of the words of the morning prayer — Modeh Ani — I thank You. Gratitude, the moment you open your eyes, for a soul returned and a day given. To be alive at the exact hour when human beings learned to teach the body to cure itself feels like standing inside that prayer.
We are not at the end of cancer. But we are, unmistakably, at the beginning of the end of its reign.

[leo @abhineezy]

@DannyWestside6 best tip converting trials to paying users?

[leo @abhineezy]

@frboulais Best tips on converting trial to paid?

[leo @abhineezy]

@thatdadjacob Best tip on converting trials?

[leo @abhineezy]

@TerekhinIvan Best tip on converting trials?

[Oliur @UltraLinx]

Humans are designed to create. This is why you get depressed if all you do is consume.

[leo @abhineezy]

@petersapps LTV LTV LTV

[Youssof Al Toukhi @Youssofal_]

- Deepseek V4 flash GA: 284B that acts like a 1T
- MiniMax H3: Frontier video gen now open source.
- Qwen 3.8 27B: 27B that acts like a 400B.

This is probably the greatest week in open source LLM history.