@simone_minnie Same idea with tumor-associated macrophages (TAMs). Bulk depletion strategies never lived up to expectation, and it turned out part of those populations play a protective role and many tumor models compensate the loss; rewiring them is a far better strategy than the depletion
Really enjoyed talking about T cell exhaustion (and some other things!) with my friend @PatrickHwuMD on his fantastic Immunoverse Podcast!
https://t.co/JMyzc0ShGZ
Out today in @Nature: Daniel Lim, MD, PhD (@danlimlab) and colleagues @UCSF have discovered that genes are controlled not only by DNA sequence and chemical epigenetic marks, but also by where they are located inside the nucleus. 🔗https://t.co/TWEzFAQ9SB
https://t.co/qA6KhH90Fv
A historic moment at #ASCO26: more than 9,000 oncologists rose for three standing ovations as Brian Wolpin, MD, MPH, Director of the Hale Family Center for Pancreatic Cancer Research, presented promising new Phase 3 results for an investigational treatment for metastatic pancreatic cancer.
In the trial, daraxonrasib helped patients with previously treated metastatic pancreatic cancer live significantly longer than those who received chemotherapy.
While more work remains, these findings offer something powerful: hope for patients and families facing one of the most challenging cancers.
As Dr. Wolpin said, “It is exciting to see that we may soon be able to help patients with metastatic pancreatic cancer in ways we haven’t been able to before, improving both survival and quality of life.”
Congratulations to the researchers and patients who made this important progress possible. 👏👏👏
Video Courtesy: @asco
A big advance, folks, for off-the-shelf, universal engineered (base-edited) T cells achieving complete response vs incurable leukemia in several patients
https://t.co/67hQ5nwEXE @NEJM
PICI is proud to support Dr. Lili Yang and @UCLA researchers developing an off-the-shelf CAR NKT cell therapy with strong potential against pancreatic cancer. Pre-clinical work shows it targets tumors where they spread and attacks with multiple mechanisms.https://t.co/0buKQoHLZ7
We stand with the Minneapolis shooting victims and their families, calling for healing, peace, and safer communities!
#MinneapolisSchool#minneapolischurch
Habemus Papam! We have a Pope!
The Cardinals gathered in the Vatican’s Sistine Chapel have elected Cardinal Robert Francis Prevost as the 267th Pope, who took the name Pope Leo XIV.
My heartfelt condolences to the Catholic Church on the passing of Pope Francis. His service and compassion touched many around the world 🙏
#PopeFrancis