Uthaibhorn NoobNim Singkham-In

Microbiologist🔬 bookaholic 📚

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

Together, these findings challenge the assumption that antibiotics lacking intrinsic antipseudomonal activity are evolutionarily neutral with respect to P. aeruginosa #idxposts

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

Static vs. cidal: it’s not complex; it’s simply incorrect
@BradSpellberg et Al
Honored to be part of this amazing group who challenges dogmas and debunk ID myths #idxposts
https://t.co/4bldEnYTK5

[The Lancet @TheLancet]

Leprosy, or Hansen's disease, remains a key global health issue.

In a Seminar, authors provide an update on key public health and clinical aspects of the disease: https://t.co/8Dl3yyL6t8

[npj Antimicrobials and Resistance @npjAMR]

How can we minimise the risk of resistance evolving during antibiotic treatment? A new computational platform to navigate collateral sensitivity and predict when treatments will fail, out now in @npjAMR

https://t.co/sbqsndoUF0

[Alí Sebastian Meza @AliSMV7]

Drug-resistant Acinetobacter baumannii: mortality, emerging treatments, and future pharmacological targets for a WHO priority pathogen

https://t.co/3JqnJZ0DAS

[Timothy Li @drtimothyli]

Timeline of chikungunya fever

Typical viral load, symptoms, involved immune cells, and antibody titres during different phases of disease are depicted

https://t.co/pF74oFG6pv

[NEJM @NEJM]

A 75-year-old man was admitted to Massachusetts General Hospital (@MassGeneralNews) because of progressive dyspnea, cough, and hypoxemia.

Gram’s staining of sputum (Panel A) shows gram-positive rods with a filamentous, branching, beaded appearance. Modified acid-fast staining of sputum (Panel B) shows reddish-pink microorganisms, a finding consistent with nocardia. Auramine–rhodamine fluorescence staining of sputum (Panel C) shows bright-green acid-fast bacilli (arrows), a finding suggestive of mycobacterial coinfection. Grocott’s methenamine silver staining of tissue from a transbronchial biopsy (Panel D) shows invasive filamentous bacteria that are consistent with nocardia. A sputum culture (Panel E) shows growth of 𝘕𝘰𝘤𝘢𝘳𝘥𝘪𝘢 𝘧𝘢𝘳𝘤𝘪𝘯𝘪𝘤𝘢 complex. Sputum treated to suppress the growth of nocardia (Panel F) shows growth of 𝘔𝘺𝘤𝘰𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘢𝘣𝘴𝘤𝘦𝘴𝘴𝘶𝘴 complex.

Read the full case details: https://t.co/C7MtqdcX1C

[IDSA @IDSAInfo]

ICYMI, IDSA released the first guidelines for the management and treatment of complicated urinary tract infections (cUTIs).

The new guidelines simplify the prior definitions of uncomplicated UTIs and cUTIs, & address treatment for cUTIs.

View guidelines: https://t.co/jauYIl0Zyv

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🆕💫Defining Bloodstream and Central Venous Catheter-Related Infections in Patients Following Haematopoietic Cell Transplantation: Position Paper of the EBMT Infectious Diseases Working Party and Practice Harmonization and Guidelines Committee #IDXposts
https://t.co/syw40t1AkH

[Clinical Infectious Diseases @CIDJournal]

The Next Step: Role of Metagenomic Next Generation Sequencing for Microbial Detection in Culture-negative Cardiovascular infections

✅ Just Accepted
✍️ @SarwatKMD @BCMHouston @RizwanSohailMD
🔗 https://t.co/VnsaG9As5P

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🆕💫Establishing Clinical and Laboratory Standards Institute M45 antimicrobial susceptibility testing methods and breakpoints for Pseudomonas other than Pseudomonas aeruginosa(POPA) #IDXposts
https://t.co/WcvvAuYAJB

[ASM @ASMicrobiology]

#MicrobiologyMonday: Pseudomonas aeruginosa releases a surfactant that displaces Klebsiella pneumoniae from solid surfaces. By pushing K. pneumoniae away, the detergent allows P. aeruginosa to better compete for limited iron. Learn more in #mBio: https://t.co/qeAiygdFRQ

[bioRxiv Microbiology @biorxiv_micrbio]

Plasticity in a bacterial global regulatory switch that drives a shift in antibiotic resistance and virulence https://t.co/BwlJPcSa4u #biorxiv_micrbio

[Timothy Li @drtimothyli]

Antimicrobial resistance, antimicrobial tolerance and heteroresistance in Pseudomonas aeruginosa

https://t.co/rItqybDibi

[npj Antimicrobials and Resistance @npjAMR]

Evolutionary steps of the multidrug resistant Acinetobacter baumanii MRSN56 sub lineage of GC1

https://t.co/xKdTlIpz20

[Cell Host & Microbe @cellhostmicrobe]

Salmonella exploits erythrophagocytosis for iron:
Subpopulation of Salmonella evades SLC11A1-mediated iron restriction by targeting iron-rich vacuoles in macrophages that ingest & degrade red blood cells, enabling faster replication of this subset
https://t.co/01gYEUfxkD

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🆕💫New Hope, New Threat:
Ceftazidime/avibactam brought promise—resistance followed fast.
England’s 4-year data shows why real-time surveillance and stewardship matter more than ever.
A must-read @Eurosurveillanc
#IDXposts
https://t.co/EzhsoNE1A3

[Trends in Microbiology @TrendsMicrobiol]

Bacterial lectins: multifunctional tools in pathogenesis and possible drug targets https://t.co/oHwkQy5kKB

[Timothy Li @drtimothyli]

Rationale behind the use of high-dose sulbactam (SUL) against CRAB infections

Conventional dose:
SUL hydrolysed by β-lactamases➡️cannot reach their targets (PBP1a/1b/3)

High-dose, extended-infusion therapy can overcome the hydrolysis by β-lactamases

https://t.co/q3rDfsziLU

[Environmental Health Perspectives @EHPonline]

#ICYMI...NEW RESEARCH: Effects of Cigarette-Derived Compounds on the Spread of Antimicrobial Resistance in Artificial Human Lung Sputum Medium, Simulated Environmental Media and Wastewater ➡️ https://t.co/nxiK38vIRV @UliKluemper @PeijuF @tudresden_de