Five cancers that used to be death sentences. Pancreatic. Glioblastoma. Triple-negative breast. Renal. Melanoma. The median survival for metastatic pancreatic cancer is still 6 months. Glioblastoma, 15 months.
Now personalized mRNA vaccines are producing complete remissions in some of these patients. Not responses. Remissions.
BioNTech’s pancreatic cancer vaccine has 6-year follow-up data. 8 of 16 patients who mounted an immune response are still alive. For a cancer that kills 95% of patients within 5 years, that's incredible.
Topol’s pyramid here maps the trajectory. From broad checkpoint inhibitors at the base to personalized neoantigen vaccines at the peak. The technology is climbing.
Regola #1: a rincari energetici NON si reagisce con sussidi.
Non si soffia su domanda (di energia, benzina) quando prezzo elevato é sintomo di *eccesso di domanda* (= offerta troppo bassa).
Così facendo si spingono i prezzi ancora più su.
É come spegnere il fuoco con la carta.