@MartinShkreli everyone's handing you Nav1.7 opinions. We built a mechanistic model — DRG nociceptor + autonomic neuron — and ran it.
Verdict: it was never a selectivity problem. A real therapeutic window exists — but it's a small island in parameter space. Miss the coordinates and you get the last 15 years.
The useful part: the model points to one cheap, up-front experiment that tells you whether a given molecule can thread it — instead of finding out in Phase 2.
Illustrative model, not a molecule — but the bottleneck was never binding. We know where the island is. Happy to compare notes.
Hot take:
Claude Cowork > Claude Code / ChatGPT Codex
Fact you can intertwine development/coding, research, hypothesis generation, off-the-beat discusssion and infinite trajectory expansion will beat any pure-coding-and-planning mode in this day and age by 10x.
I am 100x
Hot take -
Very smart individuals working obsessively with latest models (e.g. Opus 4.7) will out-win clawdbot/automation agents by 10x for the next 6 months.
Codifying raw intelligence is still outside of frontier models/agents for now.
How to accelerate everything:
1. You deep learn something in your area of expertise using notebooklm + claude.
2. You set https://t.co/EUPsKrFnJw chat with github + vercrl flow to auto generate work.
3. You deep research using Manus and add findings to step #2 for continous iteration.
Repeat by extending knowledge (#1) and research (#3).
You will become 100x.
Delpho has acquired the USDV ticker on @HyperliquidX for our upcoming stablecoin.
Over the coming weeks we will begin rolling out beta access to early users, ecosystem partners and capital allocators.
@JamesonCamp How can you pay a premium for something is real if there are no specialists to verify it/pass their deeo judgement?
How do you get innovation in medical/energy as suggested without specialists?
@calvinfroedge Sinai was relased in peace talks quite a while back, I know - my father was there with his tank squad and so was my mother as an army paramedic.
I was personally in Sinai 20 years ago in a family vacation, was great.
You really know me, my people and our joint agenda so well.
Humanity cultivated the grain, then grain switched to cultivating humanity.
Humanity cultivated the computer, now the computer is cultivating humanity.
AGI isn't the inflection point. We already crossed it.
Never Let Your Stables Sit Idle 🛡️
plvHEDGE delivers real yield across all market conditions, earning 22.69% APR while keeping depositors liquid.
It is the perfect tool to add to your portfolio playbook.
Open for deposits now ⇓
https://t.co/E2lERIkgEz
@Colasama@iliensinc There's like 100m of lending liquidity in HyperEVM, they just need to supply + borrow stables/BTC/ETH at 30%-40% LTV (and sell that).