Adithya Sriram

theoretically a physicist

[Joyce Carol Oates @JoyceCarolOates]

this is so touching! but probably the dog greets her exactly like this when she returns after an hour.

[Federico Ghimenti @FedeGhimenti]

1/ StatPhys helps analog computing! We investigate the interplay between geometry and dynamics of the coherent Ising machine against problems with hidden and planted solutions https://t.co/qgHStiPK87 w/ @adithya_sriram @atsushi_y1230 @SuryaGanguli @hmabuchi 🧵

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

[Andreas Tolias Lab @ Stanford University @AToliasLab]

After 7 years, thrilled to finally share our #MICrONS functional connectomics results!

We recorded activity from ~75K neurons in visual cortex in a single mouse, then mapped its wiring using electron microscopy. To systematically characterize neuron function, we built the first foundation model of the mouse visual cortex—trained via deep learning on data pooled from multiple mice and visual cortical areas.

Our foundation model generalized to new neurons, animals, and even unseen stimulus domains. It also accurately predicted entirely new modalities, such as anatomically defined cell types. Importantly, this robust generalization enabled us to create accurate functional digital twins of individual mouse brains.

Using the digital twin of the MICrONS mouse—where we knew the exact neuronal wiring—we discovered that neurons don’t connect randomly, even when anatomically positioned to do so. Instead, given multiple potential partners (axons near dendrites), neurons preferentially choose partners with similar feature selectivity (“what”) rather than receptive field overlap (“where”).

Foundation models offer a powerful approach to systematically decode the neural code of intelligence.

Huge thanks to @IARPAnews for funding this groundbreaking effort through the @BRAINinitiative, and to our amazing team at @Stanford @StanfordMed @bcmhouston, @Allen, @Princeton, @uniGoettingen and others!

#Neuroscience #MICrONS #NeuroAI #Connectomics #FoundationModels #AI

https://t.co/Rb9rypR9zA

[Dr. Parik Patel, BA, CFA, ACCA Esq. @ParikPatelCFA]

It’s not a loss if you don’t sell

[Benjamin Ryan @benryanwriter]

I have people over to dinner about 15 to 20 times per year. I am invited over to dinner zero to one time per year. People often behave as if a social invitation is an onerous burden. They are in a long-term relationship with themselves.

[Roger Federer @rogerfederer]

Vamos, @RafaelNadal!

As you get ready to graduate from tennis, I’ve got a few things to share before I maybe get emotional.

Let’s start with the obvious: you beat me—a lot. More than I managed to beat you. You challenged me in ways no one else could. On clay, it felt like I was stepping into your backyard, and you made me work harder than I ever thought I could just to hold my ground. You made me reimagine my game—even going so far as to change the size of my racquet head, hoping for any edge.

I’m not a very superstitious person, but you took it to the next level. Your whole process. All those rituals. Assembling your water bottles like toy soldiers in formation, fixing your hair, adjusting your underwear... All of it with the highest intensity. Secretly, I kind of loved the whole thing. Because it was so unique—it was so you.

And you know what, Rafa, you made me enjoy the game even more. 

OK, maybe not at first. After the 2004 Australian Open, I achieved the #1 ranking for the first time. I thought I was on top of the world. And I was—until two months later, when you walked on the court in Miami in your red sleeveless shirt, showing off those biceps, and you beat me convincingly. All that buzz I’d been hearing about you—about this amazing young player from Mallorca, a generational talent, probably going to win a major someday—it wasn’t just hype.

We were both at the start of our journey and it’s one we ended up taking together. Twenty years later, Rafa, I have to say: What an incredible run you’ve had. Including 14 French Opens—historic! You made Spain proud... you made the whole tennis world proud.

I keep thinking about the memories we’ve shared. Promoting the sport together. Playing that match on half-grass, half-clay. Breaking the all-time attendance record by playing in front of more than 50,000 fans in Cape Town, South Africa. Always cracking each other up. Wearing each other out on the court and then, sometimes, almost literally having to hold each other up during trophy ceremonies.

I’m still grateful you invited me to Mallorca to help launch the Rafa Nadal Academy in 2016. Actually, I kind of invited myself. I knew you were too polite to insist on me being there, but I didn’t want to miss it. You have always been a role model for kids around the world, and Mirka and I are so glad that our children have all trained at your academies. They had a blast and learned so much—like thousands of other young players. Although I always worried my kids would come home playing tennis as lefties.

And then there was London—the Laver Cup in 2022. My final match. It meant everything to me that you were there by my side—not as my rival but as my doubles partner. Sharing the court with you that night, and sharing those tears, will forever be one of the most special moments of my career.

Rafa, I know you’re focused on the last stretch of your epic career. We will talk when it’s done. For now, I just want to congratulate your family and team, who all played a massive role in your success. And I want you to know that your old friend is always cheering for you, and will be cheering just as loud for everything you do next.

Rafa that!

Best always, your fan, 

Roger

[Lakshya Jain @lxeagle17]

Forgive the soapboxing. My only personal thoughts on what’s next. No prescriptions, no blame. Not qualified for that. Just my loose prior for what comes, as someone who thought Trump had a very good shot of getting back into office with a trifecta.

[Joe @JoePostingg]

Kamala mostly ran a good campaign, and the American people are terrible is my takeaway.

[Victor Shi @Victorshi2020]

What I see. A very long line of UPenn students barely after polls opened at 7am, so excited to vote. Students are smiling & taking selfies of their voting experience. This gives me so much hope & it should give you hope too.

[ettingermentum @ettingermentum]

Truth Third Impact

[Adithya Sriram @adithya_sriram]

Lmao

[Dave McCormick @DaveMcCormickPA]

Fun tailgate in Philly today 🏈

Excited to watch the Steelers throttle the Raiders!

[Rafa Nadal @RafaelNadal]

Mil gracias a todos
Many thanks to all
Merci beaucoup à tous
Grazie mille à tutti
谢谢大家
شكرا لكم جميعا
תודה לכולכם
Obrigado a todos
Vielen Dank euch allen
Tack alla
Хвала свима
Gràcies a tots

[The New York Times @nytimes]

News Analysis: With President Biden no longer in the race, Donald Trump would be the oldest person ever to serve in the Oval Office. But his rambling, sometimes incoherent public statements have stirred concern among voters. https://t.co/fodACXMWR7

[US Open Tennis @usopen]

This is cinema.

[Roose @RuNoseP]

.@DNC let this woman speak right now

[UAW @UAW]

If we want the war in Gaza to end, we can’t put our heads in the sand or ignore the voices of the Palestinian Americans in the Democratic Party. If we want peace, if we want real democracy, and if we want to win this election, the Democratic Party must allow a Palestinian American speaker to be heard from the DNC stage tonight.

[Arab Americans For Progress @aaforprogress]

STATEMENT: Uncommitted delegates urge the Democratic Party to reject a hierarchy of human value by ensuring Palestinian voices are heard on the main stage. We are learning that Israeli hostages’ families will be speaking from the main stage. We strongly support that decision and also strongly hope that we will also be hearing from Palestinians who’ve endured the largest civilian death toll since 1948.

[Andy Murray @andy_murray]

Never even liked tennis anyway.