Mind blowing paper from the Garcia lab by the one-and-only @karstenhouse_14 ! Congratulations to the entire team!
De novo design and structure of a peptide-centric TCR mimic binding module https://t.co/VvJF0ZtiCC
Thrilled to share our work (& my first, co-first author paper! w/ @CaveneyNA & C. Pollman) from the Garcia & Piehler groups, out today in @MolecularCell: We
propose a canonical hexameric signaling mechanism for the common beta cytokine family: https://t.co/flTCBRcraN
In this work, we bring OrthoRep’s mutation rate up to 10^-4 substitutions per base, allowing us to durably hypermutate and evolve chosen genes in vivo at 1-million times the genomic mutation rate of the host yeast cell. What does this afford? https://t.co/5Cgn39jpax
Thrilled to be leading this international, multidisciplinary team of TCR Matchmakers that made the #Grandchallenge shortlist. We look forward to combining immunology, engineering, and AI to address pairing TCRs with antigens, a key problem in our field. @CancerGrand
1. Excited to share our work-the formal version of last year's first preprint of K+ selective ChR (KCR) structures https://t.co/iL6n6CNX3i 'Structural Basis for Ion Selectivity in Potassium-Selective Channelrhodopsins' published in @CellCellPress!
https://t.co/9aucR9PoQh (1/9)
📢 Announcing the 2023 Rising Stars in Engineering in Health cohort, selected from >200 talented postdocs, researchers & senior grad students. Workshop hosted by @CornellBME Sept 22-23, in partnership w/ @ColumbiaBME@CUSEAS@ColumbiaMed, @JHUBME
More: https://t.co/IL8MZPSPDO
Delighted to share a summary of my recent research paper on Deploying synthetic coevolution and machine learning to engineer protein-protein interactions! We
developed a new approach for coevolution of protein interfaces! (1/8)
https://t.co/tu9xkWyyjZ
Things my colleagues can do that no ML model can yet: design enzymes to catalyze a reaction that's not just new to nature but also to synthetic organic chemistry!
@yang2biocat
https://t.co/tOfGFQeeRI
Grateful to the dedicated team behind this paper for pushing the boundaries of protein research! Special thanks to Chris and Kevin, along with Aly, Ben, Mason and Sai. Our work establishes a solid foundation for future investigations, promising exciting applications! (8/8)
By advancing protein engineering, we envision revolutionary biotechnological innovations, reshaping our understanding and manipulation of protein interactions. (7/8)