Aiya Yesbolatova

VRF @BrownUniversity | Founder @GDSC_SOKENDAI | WTM Ambassador | PhD Candidate @NIG_idenken & @SokendaiU | 3D Genome & Aging

[Aiya Yesbolatova @aiyaYes]

It was wonderful to hear stories of #developerstudentclubs leads about their experience with Google Pixel products, technologies, achievements in app development and entrepreneurship and unique
aspirations!
@google https://t.co/x39pgQhVg1

[Takashi Akera @TakashiAkeraLab]

🚨Another open position in the lab! A long-term Staff Scientist position for people who love working on the bench!!👩🏻‍🔬👨‍🔬The Staff Scientist will function semi-independently in the lab to manage multiple projects 🧬🐭🔬#meiosis4eva

[Aiya Yesbolatova @aiyaYes]

@margaretwhua I'm interested!

[Takashi Akera @TakashiAkeraLab]

🚨Please repost!! 🧬We are hiring POSTDOC now!! Fully-funded 5-year position 👩🏻‍🔬👨‍🔬

[Bo Wang @BoWang87]

This is really cool (and wild):

Scientists simulated a complete living cell for the first time. Every molecule, every reaction, from DNA replication to cell division.

The paper (Luthey-Schulten et al., Cell 2026, https://t.co/PXxXWKC8yp), just out today, used JCVI-Syn3A — a synthetic minimal bacterium with fewer than 500 genes. A 3D+time simulation of the full 105-minute cell cycle: DNA replication, protein translation, metabolism, division. Every gene, protein, RNA, and chemical reaction tracked through physical space.

It took years to build. Multiple GPUs. Six days of compute time per run.

And this is the simplest possible cell.

A human cell has ~20,000 genes. It lives in tissue. It interacts with neighbors. It differentiates. It responds to drugs in ways that depend on context we haven't fully measured.

Mechanistic simulation of the minimal cell costs 6 GPU-days for 105 minutes of biology. You cannot scale that to human cells. The complexity isn't 40x harder. It's exponentially harder.

This is why the field pivoted to data-driven models. You can't hand-encode the regulatory wiring of a human hepatocyte. But you can learn it — if you have the right perturbation data collected across enough diverse biological contexts.

The two approaches aren't competing. Papers like this generate the ground truth that future ML models need for validation. But the path to a clinically useful virtual cell runs through foundation models, not through scaling up mechanistic simulation.

Amazing work!

[Motoshi Hayano @HayanoMotoshi]

博士課程3年目の学生が、指導教員に「君は自転車を発明するためにここにいるのではなく、乗り方を学ぶためにいるのだ」と言われたとするエピソード

日本では、現在、人口100万人当たりの博士号取得者は123人であり、韓国やアメリカと比較しても少ない水準であり、2040年��でに3倍に増やすという政府方針が打ち出されている。

しかし、学生が「精神的な安心感」や「研究に没頭できる環境」にはまだまだ乖離があり、その支援が充足しない限り、人数を増やしても、十分な教育、マインドセットの変化を促すことはできない。

解決策
RA（リサーチ・アシスタント）の雇用化: 欧米のように、学生を大学の「職員」として雇用し、生活給として十分な給与と社会保障を提供。これにより、学生は「経済的不安」というノイズを消し、研究に集中。

企業との共同フェローシップ: 企業が博士学生の学費・生活費をスポンサーし、卒業後の���用を前提としない形での自由な研究支援を行う（フィランソロピー的な投資）。

メンターシップ改革：キャリアメンター、メンタルヘルスメンターなど、利害関係のない第三者が学生をサポートする仕組みを制度化

プロセスの評価:論文が出たかどうか（自転車を発明したか）だけでなく、実験手技、論理的思考、プロジェクト管理能力など（乗り方）の習得度合いを評価軸に加える。

応用可能な教育プログラム：研究そのものだけでなく、「プロジェクトマネジメントのスキル」「プレゼン力」「リーダーシップ」など、どの業界でも通用するスキルの教育を必修化

日本の政策は資金投入（ハード面）も必要だが、指導教員の意識改革やメンタルサポート体制、キャリアの多様性��保といった「ソフト面」の成熟が、次の重要なステップ
https://t.co/46c3GZp8C7

[Shilatifard Lab @ShilatifardLab]

If you are interested in the mechanisms of 3D genome folding, long-range regulatory interactions, and their roles in developmental gene regulation and how their misregulation can cause human disease—and want to learn how computational approaches can predict chromatin architecture directly from DNA sequence—this tour-de-force study is well worth reading. Congratulations to Feng Yu @yuefeng_1 and colleagues at Northwestern Biochemistry and Molecular Genetics on an outstanding contribution. @NU_BMG_SQE @NUFeinbergMed @Nature @MolecularCell @CellPressNews @theNASciences @ScienceMagazine https://t.co/rjcb8KQYB5

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

Senescent cells secrete chromatin components via senescence-associated extracellular particles --- New study from recently graduated PhD student in the lab, Lana Zaretski, co-supervised by Malene Hansen @thehansenlab and myself. Great job, Lana! https://t.co/Cd9rbkCOjR

[Aiya Yesbolatova @aiyaYes]

Recently I had the chance to be a guest teacher at the Manaweb School Event in Fukuoka, and it became one of the most refreshing experiences I’ve had in a long time.

[Aiya Yesbolatova @aiyaYes]

“Good smile! Good voice!
Aiya worked well using all English. She crouched down to the kids’ level and listened carefully, which left a very good impression.” — Kijima-san

I’m deeply grateful for this experience and for every moment.

[Aiya Yesbolatova @aiyaYes]

@kinu おめでとうございます！！

[Anders Sejr Hansen @Anders_S_Hansen]

(1/8) Excited to see our collab w. @ViraatGoel Ed Banigan @ngaboreden James Jusuf, Leonid Mirny and Gerd Blobel out in @NatureSMB https://t.co/2Ri3nom8jt

This was co-submitted with A Schooley and Job Dekker's preprint https://t.co/0Y6CmePM1Z which should also be online soon.