Alain Laederach

RNA Folding Bioinformatics, Science, and a bright sunny day in the alps.

[Alain Laederach @alaederach]

Data on Researchers’ Self-Reported Disability Status https://t.co/kXDYkpLqro

Interesting read, I am glad to see @NIH highlighting this data!

[Yiliang Ding @YiliangDing]

RNA G-quadruplex rocks!Our exciting story is finally out! Novel insights on how plants adopt RG4 in response to cold. https://t.co/OYb7EyhKTs @JohnInnesCentre @ERC_Research @BBSRC @GEN_ISP_JIC @HaopengYu @XiaofeiYang14 @Ilexpurpurea @sduncan015 @kitkwok6

[Meredith Corley @CorleyTwin2]

DNA uses thymine (T); RNA uses uracil (U) instead. Why??
Somehow I only recently learned the reasons and it’s quite neat. And as is typical in biology there are still open questions about it 🧵

[Alain Laederach @alaederach]

@CorleyTwin2 I vote for 3 but I maybe a little biased in my opinion!

[Alain Laederach @alaederach]

I enjoyed Wah Chiu’s talk here at #ncrna2022, his work in collaboration @RDasLab on L-21 group I intron structure brought back excellent memories of misfolding RNAs!

[Alain Laederach @alaederach]

Excited to be at the #ncrna2022 meeting in person again, biggest turnout since this meeting started 25 years ago!

[Alain Laederach @alaederach]

@ewang2323 @bio_eclipse Nevermind, I managed to find the original thread and find the link to your very nice Cellstemcell paper! And you did your due diligence and submitted to GEO at https://t.co/x7u2bjOMv1. One question, do you remember which GRC38 version you used?

[Alain Laederach @alaederach]

@ewang2323 @bio_eclipse Hey @ewang2323 did you ever publish this work and is the an accession number for the ZFP36L2 eCLIP data in SRA/GEO?

[Alain Laederach @alaederach]

Registration in open for the NC RNA 2022 tool and target meeting, with a great lineup of speakers. Please do consider registering at https://t.co/XMY9WTi1Rd!!

[Alain Laederach @alaederach]

RNA structure landscape of S. cerevisiae introns https://t.co/mGptufc1R9 Very nice preprint by @RDasLab and @RiboHipster on pre-mRNA structure, glad to see we aren't the only ones thinking structure has got to be doing something in those introns!

[Dr. Anita Corbett- (She/her) 🏳️‍🌈 @acorbe2]

Continuing with a truly outstanding slate of speakers @FASEBorg Dr. Silvia Ramos from @UNC_BCBP described some of her recent work defining the role of ZFP36L2 in regulating specific RNA targets in mice recently published in @NAR_Open #RNADecay #PCGE22

[Alain Laederach @alaederach]

Excited to attend @NC_RNA_Meeting October 13-14 in the triangle this fall. Check out https://t.co/XMY9WTzDfN for updates!

[Michael Love @mikelove]

@peiferlabunc @alaederach Why that’s Microtubule Associated Protein Tau

Expressed in brain, complex splicing

https://t.co/TD15BlFANu

[Alain Laederach @alaederach]

Clearly the best way to get everyone in your lab to laugh is to make a joke at the expense of the PI! #science #RNA I think we are going to use this one on https://t.co/QHJ6FSGsv4

[Alain Laederach @alaederach]

@mikelove @peiferlabunc Thanks Michael for clarifying my acronyms!

[Alain Laederach @alaederach]

Our latest work on mRNA structure and splicing where Jaya Kumar in my lab predicted the footprint of the spliceosome on pre-mRNAs and used this in conjunction with endogenous structure probing to predict PSI in MAPT.

https://t.co/TV3SBNH7Qq

[Michael Love @mikelove]

@peiferlabunc @alaederach PSI = percent spliced in, a metric for how often a particular exon is included in the transcripts, for a given sample

[Alain Laederach @alaederach]

@ChenRNAChen Yes, that is what the model predicts!

[Alain Laederach @alaederach]

@FoxLabDuke @Sallen822 @UNC_Biology Very excited to have Scott come to UNC!!!

[FoxLabNC @FoxLabNC]

Scott Allen @Sallen822
is now Dr Scott Allen! Fantastic thesis defense today. Up next for Scott is a postdoc
@UNC_Biology
with
@alaederach
and Kevin Weeks.