Albert

"Rugged Individualist" . thank you for your attention to this matter

[Sasha Yanshin @sashayanshin]

Imagine you build a successful business in the UK.

It makes £10 Million profit.

First you pay 25% Corporation tax = £2.5 Million.

Your net profit after tax is £7.5 Million.

Average UK P/E ratio for public companies is ~15.4. Let’s use that as a proxy.

This business is worth £7.5 Million x 15.4 = £115.5 Million.

UK Government wants to tax you 2% wealth tax on your net worth above £10 Million per year. 2% x (115.5 - 10) Million = £2.11 Million.

So you have to pay yourself a dividend of £3.48 Million which will pay 39.35% dividend tax to pay the wealth tax.

Remaining Company profit = £4.02 Million.

If you want to have that money, you have to pay dividend tax again. After the tax you have £2.44 Million.

So the net effect is that if you make £10 Million, the UK Government will take 75.6% of it as tax.

Almost half of this tax comes from the 2% wealth tax.

It’s an extra 35% tax on profit in this example.

Problem is dimwits who were “good at maths at school” and politicians don’t understand basic maths.

This will mean absolutely nobody will take the risk to invest or start a business in the UK.

What is the point? If you are lucky enough to succeed, you will get punished hard.

Jobs will not be created. Investment will dry up immediately. Anyone starting a business who is young enough will move.

The power of FAFO will lead to a collapse in living standards and a collapse in economic growth.

This will destroy the UK economy and be the biggest own goal in a generation.

Why are we blindly walking into a self-orchestrated financial disaster?

But hey - it sounds good because an idiot YouTuber who has no clue said so.

It has good vibes.

Tax the millionaires! What is so bad about a 75.6% tax exactly?

[Marc Andreessen 🇺🇸 @pmarca]

Honestly we don’t even know what that little squiggle means.

[@jason @Jason]

90s were different

[Elon Musk @elonmusk]

@RampCapitalLLC What’s Threads?

[GREG ISENBERG @gregisenberg]

The computer is being reinvented in the agentic era:

- The model is the new CPU.
- The harness is the new OS.
- Hallucinations are the new bugs.
- The context window is the new RAM.
- Skills are the new apps.
- Markdown files are the new config.
- Evals are the new QA.
- Context is the new moat.
- Permissions are the new firewall
- Trust is the new bottleneck.
- Prompt is the new programming language
- Agent is the new software.

Anything you dream of, you can build.

This is the greatest time ever to be building with computers.

[Mgoes (bio/acc 🤖💉) @m_goes_distance]

We are barely 6 months into 2026

here's some of the most unhinged biotech and longevity stuff this year alone:

- germline editing hit 100% efficiency with zero chromosomal abnormalities using base editing instead of CRISPR cutting

- a baby was born from an embryo selected for an IQ in the 99.99th percentile. the company behind it openly calls it eugenics

- Midjourney, an AI image company, pivoted into medical hardware with a full body ultrasound scanner that takes 60 seconds

- China reversed type 2 diabetes in a patient using stem-cell-derived insulin cells. insulin stopped completely. the body took over

- an Australian founder sequenced his dog's cancer, used AI to design a custom mRNA vaccine, and watched the tumor shrink

- daraxonrasib nearly doubled survival in pancreatic cancer. one of the deadliest cancers on earth. a 42 second standing ovation followed

- retatrutide hit 30% bodyweight loss in Phase 3. bariatric surgery territory from a peptide

- Eli Lilly bought Verve Therapeutics for $1B after one gene edit delivered permanent cholesterol reduction in human patients

- Life Biosciences dosed the first human with a therapy built to reverse cellular aging. the anti-aging era entered the clinic

- Demis Hassabis raised $2.1B for Isomorphic Labs on top of billions in pharma partnerships to build AI-designed drugs

- Brian Armstrong's NewLimit raised $435M at a $3.1B valuation to pursue cellular rejuvenation

- China launched a 2,000 person trial testing stem cells for age-related decline. the largest organized longevity study ever attempted

forget software, biology is the new frontier.

and the people building the infrastructure behind all of this are the ones we actually want to talk to

SuperHuman Fund backs the layer underneath the headlines: peptide validation, biological age diagnostics, trial site intelligence, BCIs, epigenetic reprogramming, and the picks and shovels nobody else is funding

if that's you, let's talk

[Bryan Johnson @bryan_johnson]

Much of the internet thinks:

> meat will remedy my autoimmune gastritis
> sunlight is the cure
> the culprit is the food I consume

These are unlikely.

The sunlight assessment is claiming low vitamin D levels are making my immune system misfire. My vitamin D has been sustainably high for years.

The meat argument claims that animal tissue contains missing nutrients that will cure me. This is a misunderstanding of my condition.

My low ferritin is a downstream consequence of autoimmune gastritis and not the cause of it. The autoimmune attack destroys my stomach's acid producing parietal cells. That compromises my gut's highly acidic microenvironment that is required to absorb iron.

As evidence, for years we’ve tried every possible oral iron formulation to correct it, including proferrin, a heme iron polypeptide similar to how iron exists in meat, lactoferrin, as well as non-complex forms including iron bisglycinate. We also tried different times of the day, and pairings to improve absorption. Nothing worked.

My autoimmune profile began at a young age when I was regularly eating red meat and was in the sun for multiple hours a day. I was diagnosed with autoimmune thyroid disease when I was 21 years old. In immunology, the connection between thyroid and stomach autoimmunity is sufficiently common and tightly linked that it has a name: thyrogastric syndrome.

My body’s genetic and immunological architecture made a mistake decades ago, failing to distinguish between my own tissues and external threats. Trying to cure a decades old, genetically driven, antigen specific immune failure by switching to a meat diet or getting sunlight is like trying to fix a corrupted line of software code by altering the temperature of the room.

If I am to fix this mistake inside my body, I first need to figure out what specifically went wrong. That’s why I am sequencing one million of my immune cells.

By isolating and sequencing these individual cells, we can identify the rogue platoon of soldiers who are doing the damage. Once we know who they are, we can design specific solutions to stop their attacks.

##

How I’m sequencing my immune system

Think of your immune cells as trillions of soldiers. Each carries a unique key designed to unlock and destroy a specific threat, like a virus or bacteria.

A standard blood test allows you to see how many soldiers you have, but not their keys. Sequencing 1 million individual immune cells allows us to read the exact pattern of the teeth on every single key.

This is important for my autoimmune gastritis (AIG) because a specific platoon of rogue soldiers has developed keys that unlock an attack on my stomach lining.

Right now, we don’t know who they are. This test will inform us of which soldiers have gone rogue and are attacking me from within.

Once we know soldier and key, we know what therapy path to pursue to shut them down.

[Paul Graham @paulg]

Step 1: Invent a new extra-bad category of crime, like "hate crime" or "terrorism", with extra-harsh punishments.

Step 2: Expand the definition of the new kind of crime to include anything, or anyone, that you want to punish extra harshly.

[Naval @naval]

@alexfe15 Libertarians are, and always will be, a rounding error.

[Naval @naval]

As the elites get kicked out of each party, we are going from Republicans vs Democrats to Nationalists vs Socialists.

[joowon @n0w00j]

what the fuck is a $200M seed round

[MTS @MTSlive]

SITUATION DETECTED: Google is investing $75 million in A24 as part of an AI research partnership, per WSJ.

Google DeepMind and A24 will develop new AI tools for film production and distribution.

[Bryan Johnson @bryan_johnson]

Am hoping to make the Forbes 30 under 30 this year.

[Piers Morgan @piersmorgan]

BREAKING: President Trump confirms Keir Starmer is resigning as Prime Minister… before Starmer has confirmed it himself. The final humiliation.

[Marc Andreessen 🇺🇸 @pmarca]

Everyone is super bullish on whatever company they just quit. 😳

[Demis Hassabis @demishassabis]

Thanks John for an extraordinary partnership and wonderful collaboration over the past 9 years! What we achieved with AlphaFold changed the world, and showed the field what was possible with AI for science and medicine, lighting the way for how AI can benefit humanity.

[Garry Tan @garrytan]

Bernie Sanders introduced a bill to seize 50% of any AI startup that crosses $200M in revenue.

The same anti-prosperity bloc spent the year trying to ban startup acquisitions, blocking the only exit 85% of founders ever get.

This is a war on building startups in America.

[Shaun Maguire @shaunmmaguire]

I think most investors are misunderstanding how soon orbital compute will ramp

99% of the difficulty was Starship

The satellites themselves are a similar level of complexity as Starlink

The bottleneck is Starship, which I believe is almost here

[Paul Graham @paulg]

If you want something from someone, make it clear what. It's not imposing to ask explicitly for something; it's imposing to be vague and make the recipient work to figure out what you want.

[Austen Allred @Austen]

Somebody has to be the richest person on the planet.

The fact that it’s the guy who popularized electric cars, made rockets reusable, and is working on curing blindness and paraplegia as a side quest seems fair to me.