Bombardo Bombardino

Pokemon GO professional player

[Alejandro Gaviria @agaviriau]

El planeta no quiere castigar a los seres humanos. Ni da gritos. Ni está mandando mensajes. Ni hace juicios morales. Este tipo de "animismo" (ahora en boga) es una farsa, producto sobre todo del oportunismo político.

[Sebastián Nohra @SebastianNohra]

Una buena señal para conocer el corazón de un personaje público es ver si su primer reflejo es tratar de ser útil o rasguñar una tajada política y generar likes.

[Bombardo Bombardino @alejo6836]

@Frunazepxnk siempre ese es el que resulta más hijueputa? ¿o como es la vuelta?

[Bombardo Bombardino @alejo6836]

@juanitoelniche al ritmo que vamos creo que pagar por un plan de celular va a ser señal de organizar la vida 🥲🥲🥲

[Bombardo Bombardino @alejo6836]

@natt_dm Bueno pero está puede ser una psicosis aguda, si amerita el ingreso por urgencias 😅😅

[Bostherian🔪🐔 @Bostherian12]

@Mario___RM A Cristiano Ronaldo solo le faltan lograr los fracasos de messi

[Sebastián Nohra @SebastianNohra]

Petro duró todo su gobierno tratando de hacerle un homenaje a “Cien años de soledad”. Sin proponérselo, se lo terminó haciendo a “El otoño del patriarca”.

[Bombardo Bombardino @alejo6836]

@rafaeltrossard @Juanorte09 que asco

[Daniela S. @missfbe]

Después de la Copa América 2024, un colombiano decente no apoyaría nunca a Argentina.
Vamos España. 🇨🇴

[Amazona @Soy_Amazona]

Ahora que Twitter tiene traducción automática, siempre quise preguntarle a los amigos de Japón si ellos se enteraron quién era Geraldine Fernández.

[Bombardo Bombardino @alejo6836]

@InformantesTV Debería darles pena hacerle publicidad a esa porqueria

[Bombardo Bombardino @alejo6836]

@DiegoAndariego jajajaja pero bien impopular

[Bombardo Bombardino @alejo6836]

@ColMadr JAJAJAJAJJAJAJJAJAJAJA

[Marco @soymarcogm]

Sigo esperando el comunicado de James que se retira de la selección.

[Bombardo Bombardino @alejo6836]

🤦🤦🤦

[Bryan Johnson @bryan_johnson]

My plan to cure autoimmune gastritis

To our knowledge, no one has ever done this to try and cure an autoimmune disease.

Context: In May, I got diagnosed with autoimmune gastritis (AIG). We found it by taking a tissue biopsy of my stomach. My immune cells are confused, causing my stomach to eat itself.

AIG stops your body from absorbing nutrients like iron and B12, and can eventually lead to cancer. It likely started decades ago when I was diagnosed with hypothyroidism when 21 years old. The thyroid and stomach are closely linked in your immune system.

I feel fortunate that I've been taking such good care of my body for the past five years as my condition would otherwise be much more severe. Millions of people are affected by this disease and are undiagnosed.

Standard of care tells you that you can’t do anything about it. That’s old fashioned.

Here is how we are going to try and cure it:

Step 0: find and diagnose the disease ✅

AIG is rarely caught early because symptoms are subtle. Early warnings are low iron and B12, but when hemoglobin and hematocrit look normal, doctors routinely miss it because there are no obvious signs of anemia.

A standard colonoscopy won't find it either, because it only checks the lower digestive tract, not the stomach. It was only through a highly targeted stomach biopsy that we found it. Even biopsies can miss it if they don't sample the exact right spots. Most people with AIG go undiagnosed.

Step 1: Map my immune system ✅

Last Thursday, I had a blood draw to isolate and decode 1 million of my immune cells. Think of your immune cells as trillions of soldiers. Each carries a unique key designed to unlock and destroy a specific threat, like a virus or bacteria.

A standard blood test allows you to see how many soldiers you have, but not their keys. Sequencing one million individual immune cells allows us to read the exact pattern of the teeth on every single key.

This is important for my autoimmune gastritis (AIG) because a specific platoon of rogue soldiers has developed keys that unlock an attack on my stomach lining.

Right now, we don’t know who they are. This test will inform us of which soldiers have gone rogue and are attacking me from within.

Once we know the soldier and key, we know what therapy path to pursue to shut them down.

Step 2: Catch the rogue soldiers

I will be getting a second biopsy from my stomach because we need to collect live tissue. We are currently planning out the logistics of getting the sample from my stomach to the lab.

We need these live cells because the initial blood tests showed the antibodies, which prove that an attack is happening, but doesn’t show us the actual rogue soldier doing the damage which is a T-cell.

The live sample will allow us to match the immune system mapping we did to the live T-cells.

Step 3: Build an early warning system

To keep an eye on the disease as we work towards a therapy, we’re building an early warning system. I'll have my blood drawn every two weeks and we’ll pair that information with wearable data to look for flare ups. This is important because the attack happens without producing symptoms that I can easily feel.

Step 4: Create a “Bryan in a dish” testing model, a miniature of my immune system

At the same time, we are taking a massive sample of my immune cells and deep freezing them (cryopreservation) for two reasons:

a) we’ll create a living lab: using these cells to replicate my immune environment in a lab dish. This allows us to test experimental drugs and therapies on my actual live cells before putting them into my body.

b) it creates a back up plan for me by preserving the raw cellular material needed for targeted rejuvenation therapies in the future.

Step 5: Build precision guided therapies to end the attack

Once we know who the rogue soldiers are, we will engineer a therapy designed uniquely for them. The trick is only turning off the rogue soldiers while leaving all the other healthy ones functioning as they are.

For safety checks, we’ll do two test runs:

1) we’ll run the therapy through a computer model that has my biology to evaluate how my molecules interact.

2) We will take my actual cells that we froze in Step 4 and watch them interact for real.

If both are successful, we’ll pursue one of four therapies:

a) fix the mistake my cells are making, restoring my immune system's natural off switches

b) teach the rogue cells to tolerate my stomach instead of attacking it

c) design smart molecules that physically plug into the rogue cells and turn them off

d) build soldiers who will track down and eliminate the rogue soldiers causing the damage

[Bombardo Bombardino @alejo6836]

@Frunazepxnk Hoy lo único malo es que el partido va a ser en la noche y no lo voy a poder ver en el trabajo como me gusta 😓🤟

[Bombardo Bombardino @alejo6836]

@Frunazepxnk lo que sobran son razones

[Talijan 7 @ELPERRON65]

@Bipolardo De quien hablas, de Cabo Verde o Argentina?

[Que remate Don Juanfran Funes @PacoA_mlg]

No veia a los uruguayos buscar con tantas ganas la tibia rival desde que se estrellaron en aquel avion en los Andes

[Esteban @EstebanVialG]

Siento que el cambio de Valverde es pura Venganza de Bielsa y me parece perfecto como conchetumare te vas a poner a hacerle la cama al técnico EN UN MUNDIAL