Probably the greatest finding of our lab 😀 Very proud of my team and very thankful for all collaborations!
https://t.co/8eYWAVqznl
N&Vs: New-found brake calibrates insulin action in β-cells https://t.co/bPw642iRsh
read here: https://t.co/oZHiANalJ7 https://t.co/8eYWAVqznl
Exciting study by Amanda Andersson Rolf et al: In vitro expansion of a human fetal #pancreas#stemcell that generates all three pancreatic cell lineages”. https://t.co/mk4MdczkTM 1/
Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
https://t.co/GKx6eslJz0
A tremendous collaborative effort led by @JohannaSiehler, @BilekovaSara and other members of the @LickertHeiko lab.
Our new paper, "NK2R control of energy expenditure and feeding to treat metabolic diseases," is out today in @Nature.
Here we identify a single receptor that can both peripherally increase energy expenditure and centrally suppress appetite.
https://t.co/6Q8nG7wFOs
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NNC2215, an insulin conjugate with a glucose-binding macrocycle and a glucoside, creates a glucose-sensitive switch that reversibly responds to ambient glucose levels, potentially reducing hypoglycaemia risk in diabetes treatment. https://t.co/cqZ8Vogq4F #NBThighlight
Proteomic predictors of individualized nutrient-specific insulin secre... https://t.co/TD8dUSyCsg is the latest work from star fellow (and current faculty job hunter) Dr. Jelena Kolic @JelenaK86.
🚀Excited to share our latest work in @LickertHeiko lab: "Resolving human α vs β cell fate allocation for generating stem cell-derived islets." Thanks to the amazing contributions from @LamaSaber95, @EunikeSetyono, and @TobiasGreisle! Read more here: https://t.co/zFobcra6Hj
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.... and following up on my previous post, I am pleased to share our article online today @TheLancetEndo
Full text available (next 50 days) via this link through Elsevier https://t.co/n2LvuTKLgA
Thrilled to share our work “A multimodal cross-species comparison of pancreas development”.
https://t.co/J3gMdTQBNH
A tremendous collaborative effort led by @Carina_K_YANG & @HannahSpitzer1, and other members of @LickertHeiko@fabian_theis, Eckhard Wolf labs.
Extremely happy to see this great cooperation with @TimoMueller_IDO and @MatthiasTschop published in @NatMetabolism. The Inceptor story continues and stay tuned, as we also found a ligand 😉 hopefully published very soon as well…
Insightful work from our @helmholtz_diabc colleagues @LickertHeiko@TimoMueller_IDO@MatthiasTschop et al corroborating Inceptor as key mediator of IGF1R & INSR signaling in diet induced obesity - validating Inceptor as promising therapeutic target 👍🎇🎉https://t.co/EXXMrzzhFg
More β cell heterogeneity, with RRβs as a subpopulation of β cells that make a disproportionally large contribution to biphasic GSIS from mouse #islets@NatMetabolism#insulin#diabetes https://t.co/Pn36xBOLW6
Excited to share our new manuscript @MolMetab This study led by @CAMBUpenn graduate student Libby Nunn explores the potential of activin type II receptor blockade to maintain muscle mass and enhance fat loss during GLP1RA in obese mice https://t.co/qlesdzHD0W