Cad1 turns ATP into phage poison
Highlight of paper by @MarraffiniLab @CellCellPress reporting type III CRISPR-Cas accessory effector, Cad1, which deaminates ATP into ITP, causing ITP accumulation & host growth arrest, thereby inhibiting phage propagation
https://t.co/Dejz1lQQB0
Adriana Mejia of the @MarraffiniLab discovers and characterizes novel bacterial immune systems against phage infection. She focuses on the mechanisms that involve recognition and targeting of modified DNA bases and how these can be used in biotech. #HispanicHeritageMonth
1/ 🧵 Thrilled to share work of @EligoBio just published in @Nature ! We show proof of principle results of efficient base editing performed on E. coli directly in the mouse gut 🦠💡 #Microbiome#SyntheticBiology https://t.co/efTztuluN9
Multitrons: simultaneous multi-site editing of individual genomes using retron arrays, now published in Nature Chemical Biology @nchembio: https://t.co/GlTCjsgLSg. Great job @alex_gonzadel and @oso_de_antojos !
Super excited and honored to be part of the 2024 cohort of the @JCChildsFund Fellows, studying extrachromosomal DNAs in cancer cells in the @J_Maciejowski lab. Very grateful to my postdoc mentor @J_Maciejowski and my PhD advisor Luciano @MarraffiniLab for their amazing support!
Delighted to share our latest preprint on my favourite piece of biology, CRISPR adaptation! tl;dr: we found that SspA, a known global regulator of bacterial stress response pathways, transcriptionally regulates CRISPR adaptation in E. coli https://t.co/2b0onEqggQ
New preprint from the lab, on the fundamental biology of CRISPR adaptation! Check out the preprint here: https://t.co/4JTpM4C5An Or, start with this wonderful highlight thread by @oso_de_antojos who led the work. @GladstoneInst@UCSF@UCSF_BTS@BioE_Beast
A study in @NatureMicrobiol shows that enzymes found in the gut resident bacteria, Akkermansia muciniphila, can convert both known and previously not recognized antigens on human red blood cells to make group O blood. https://t.co/LZnRB926Yr
Looking for a postdoc? Fascinated by phage-bacteria interactions?
2-y position at the University of Copenhagen (UCPH), based at UCPH PLEN w/ @LeiseRiber, in collab with our team at UCPH Micro! 🧬🔬 🇩🇰
https://t.co/Kj0a1ygRuJ
Please share with interested colleagues!
The 2024 symposium on the immune system of bacteria is over. Thank you everyone for the great science, discussions and vibes.
See you next year in Paris on April 8th-10th 2025.
To promote a diverse pool of speakers/reviewers (etc), we introduced at SISB2024 a list of PIs in bacterial immunity searchable by career stage, country and gender.
Inspired by @GaetanBurgio. Mail me to add your name or correct mistakes!
https://t.co/Mmwt6xtED3