Amsterdam Physiology

Department of Physiology at Amsterdam UMC focusing on the mechanisms underlying the pathogenesis of genetic and acquired muscle and vascular diseases

[Amsterdam Physiology @AmsterdamPhys]

Amsterdam will host the EMC next year (September 20th-24th, 2025), in the beautiful Royal Tropical Institute. Save the dates and we hope to see many of you muscle aficionados here in '25!

#myotwitter #muscle

[Amsterdam Physiology @AmsterdamPhys]

The department was well represented this past week at the 51st European Muscle Conference in Ljubljana. We had several abstracts selected for talks, with PhD students Osman Esen and Sila Algül both taking home prizes for their presentations. Nice work!

[Jan Willem Buikema @Jan_W_Buikema]

Jolanda van der Velden on Mechano-energetic Uncoupling in Hypertrophic Cardiomyopathy #BCVS2024 @AHAScience @AHAMeetings @JolandavanderV4

[Amsterdam Physiology @AmsterdamPhys]

Congrats to Edgar and the whole team!

[Edgar Nollet @EdgarN]

🚨Excited to share our latest study on the metabolic landscape in hypertrophic cardiomyopathy, out now in @Circ_Gen !
Link: https://t.co/0zS9YXXB8Y

🧵⬇️

[Kirby Lab @KirbyLab_AmsUMC]

Happy to see this finally out. Huge thanks to members of the @LammerdingLab for all their work on this project and their ongoing collaboration and support. @cddpress

#laminopathies #muscledisease #musculardystrophy

https://t.co/MTGKByfn9j

[Amsterdam Physiology @AmsterdamPhys]

Three projects have been awarded to members of the department as part of the ZonMw Open Competition funding for innovative research!

Congrats to @JolandavanderV4, Peter Hordijk, Ed Eringa, Josine De Winter and all associated team members!

https://t.co/EXHfZ4baGO

[Amsterdam Physiology @AmsterdamPhys]

Check out recent work from the Ottenheijm group, just published in @ScienceTM, where they demonstrate that TNNI1 variants cause muscle disease with variant-specific pathomechanisms, leading to either a hypo- or a hypercontractile phenotype. #MyoTwitter

https://t.co/TyVFxl8ZrT

[JMCC Plus @JMCCPlus]

New Paper Alert! 📜📜

Have you ever wondered what is exactly expressed in the cell line you use?

In this recent paper from @AmsterdamPhys authors show that widely used mouse cardiac microvascular cells don’t express essential endothelial markers...

https://t.co/wUak9ydXkN

[Amsterdam Physiology @AmsterdamPhys]

#hypertrophiccardiomyopathy #heartdisease #heartfailure

[Amsterdam Physiology @AmsterdamPhys]

Sodium–glucose cotransporter 2 inhibitors (SGLT2i) are anti-diabetic drugs that show beneficial cardiovascular outcomes in patients with acquired heart failure, but can they correct cardiomyocyte dysfunction induced by hypertrophic cardiomyopathy (HCM) sarcomere mutations?

[Amsterdam Physiology @AmsterdamPhys]

Here, Wijnker and colleagues report that SGLT2i acutely enhances relaxation in human engineered heart tissues, especially in tissues harbouring HCM mutations and following prolonged culture. Thus, SGLT2i may represent a potential therapy to correct cardiac dysfunction in HCM.

[Amsterdam Physiology @AmsterdamPhys]

Application is open, see:
https://t.co/T3rRMDuU56

See you in Amsterdam!

#mastersdegree #cardiovascular #amsterdamcardiovascularsciences #universityofamsterdam #amsterdamumc

[Amsterdam Physiology @AmsterdamPhys]

𝐋𝐨𝐨𝐤𝐢𝐧𝐠 𝐭𝐨 𝐝𝐨 𝐚 𝐌𝐚𝐬𝐭𝐞𝐫’𝐬 𝐝���𝐠𝐫𝐞𝐞 𝐚𝐧𝐝 𝐡𝐚𝐯𝐞 𝐚𝐧 𝐢𝐧𝐭𝐞𝐫𝐞𝐬𝐭 𝐢𝐧 𝐜𝐚𝐫𝐝𝐢𝐨𝐯𝐚𝐬𝐜𝐮𝐥𝐚𝐫 𝐛𝐢𝐨𝐥𝐨𝐠𝐲?

𝐇𝐚𝐯𝐞 𝐚 𝐥𝐨𝐨𝐤 𝐚𝐭 𝐭𝐡𝐞 𝐂𝐚𝐫𝐝𝐢𝐨𝐯𝐚𝐬𝐜𝐮𝐥𝐚𝐫 𝐒𝐜𝐢𝐞𝐧𝐜𝐞𝐬 𝐌𝐚𝐬𝐭𝐞𝐫 𝐚𝐭 𝐀𝐦𝐬𝐭𝐞𝐫𝐝𝐚𝐦 𝐔𝐌𝐂/𝐔𝐯𝐀!

[Amsterdam Physiology @AmsterdamPhys]

Plenty of opportunities for an excellent research training and challenging internships in Amsterdam and abroad!

For information, contact the coordinators:
Prof dr Peter Hordijk, [email protected]
Prof dr Vincent Christoffels, [email protected]

[Amsterdam Physiology @AmsterdamPhys]

From Marie Curie to Rosalind Franklin, women have been smashing glass ceilings and petri dishes alike. So, as we celebrate the International Day of Women in Science, let's tip our imaginary hats to all the ladies of science.

#WomenInScience #WomenInSTEM

[Amsterdam Physiology @AmsterdamPhys]

Reproducibility of stem-cell-derived models is an important aspect of animal-free innovations moving forward. A Dutch steering group, Amsterdam 4R, chaired by @JolandavanderV4, has been formed to address this issue. Read more about this initiative below:

https://t.co/Vh0xcy4Rkr

[Lammerding Lab @LammerdingLab]

Interested in nuclear #mechanobiology and attending the @ASCBiology/@EMBO #cellbio2023 meeting in Boston next week?
Make sure to visit the "Nuclear Mechanobiology" subgroup session on Sat, Dec. 2, from 1:00 to 3:30pm with an excellent lineup of speakers.
https://t.co/vbBvJAXjhE