🚨Out in @MolecularCell, “Molecular Determinants and Signaling Effects of PKA RIα Phase Separation” by @a_hardy_girl establishes that a non-canonical, active PKA R:C complex in RIα condensates sequesters PKA activity from the cytosol. https://t.co/olxSqXBH4c
The #DiscoverBMB Graduate Student Diversity, Equity and Inclusion Travel Award winners poster session starts at 7 p.m. Central in Exhibit Hall 4A. Enjoy camaraderie, good food and incredible research showcased by award recipients.
Today at 2:45 p.m. in Room 217C at #DiscoverBMB: Join us to decipher the mechanisms by which phase separation controls various aspects of cell signaling and the role of post translational modifications in regulating phase separation.
Speakers: https://t.co/fdNIQomtVF
Our paper on functional discovery of protein degradation and stabilization effectors with proteome-scale induced proximity screens is out in its final version! 1/ https://t.co/vzNbJyR2rk https://t.co/5S9i7UG7JL
Targeted protein degradation/ stabilization are of therapeutic value, but only few E3 ligases and deubiquitinases have been of use for this purpose. Work @Nature adds to this repertoire, providing a catalogue of effectors of protein stability. https://t.co/Zo6lB2sUbP
From the February issue—
Integrating #ClinicalCancer and PTM Proteomics Data Identifies a Mechanism of ACK1 Kinase Activation, by Eranga R. Balasooriya, Joshua L. Andersen et al.
https://t.co/3yvcNixfRo
@MGHCancerCenter @BYU@huntsmancancer
We are immensely grateful to @utahcityutah for their generous land donation and for the exciting vision they have created. This new campus in Utah County promises expanded world-class care, breathtaking views, and reduced travel burden for patients: https://t.co/bCg4cyjxAA
Thanks to the visionary developers of @UtahCityUtah—Woodbury Corporation & Flagship Companies, along with @VineyardCity, we've received an incredible $20 million land donation. This will pave the way for a state-of-the-art HCI campus in Utah County. https://t.co/l6FD3v1o0X
If you’re coming to #DiscoverBMB, please join @Castaneda_lab and us for an interest group on phase separation/condensates and cell signaling. Fantastic speaker lineup! 👇
At #DiscoverBMB 2024, forge connections while discussing phase separation & cell signaling at our interest group, "Signal transduction: an emergent behavior of bimolecular condensates." Hosted by @Castaneda_lab & @andersenlab, you don't want to miss it!
https://t.co/1D9A8FnqC5
Alana L. Welm, recipient of the 2023 @AACR Outstanding Investigator Award for Breast Cancer Research, delivered her award lecture this afternoon during #SABCS23. @AlanaWelm @UTHealthSAMDA @AACR
Our lab at @huntsmancancer@UUtah is hiring a junior-level tech!
Come work on fascinating questions in signaling, development, and cancer with a dynamic and collaborative team.
Great opportunity for future grad or med school applicants. Please RT!
https://t.co/vQEqNAM2rF
Excited to see this new pre-print out! Gets at the role of ubiquitin condensates as platforms for assembly of autophagy machinery. Fun collaboration w @jenscs83 @DavidGBroadbent@ColtenMcewan#autophagy
The formation of ubiquitin rich condensates triggers recruitment of the ATG9A lipid transfer complex to initiate basal autophagy https://t.co/Lei9PXrEC4 #biorxiv_cellbio
We applaud @POTUS Biden's announcement that he will appoint AACR member @KimrynRathmell to succeed @NIHDirector Monica Bertagnolli as the next Director of @theNCI. The AACR looks forward to working with Dr. Rathmell to advance our shared mission. https://t.co/R7YXS8nVIn
New @biorxivpreprint from our lab by @Qian37774492 on a covalent 14-3-3 molecular glue with the transcription factors YAP and TAZ and using this glue as a 14-3-3 recruiter to sequester nuclear neo-substrates into the cytosol! Thanks to #AppleTreePartners & @themarkfdn
https://t.co/Vd2NXF6m0i