Andreas Tiffeau-Mayer

Quantitative immunology & biological physics.
Q-Immuno Lab PI @iit_ucl & @ucl_ipls
past: Lewis-Sigler Fellow @Princeton, PhD @ENS_ULM
Also @qimmuno.bsky.social

[Benjamin D. Greenbaum @bengrbm]

Understanding which antigens are targetable in a tumor forms the basis for personalized immunotherarapies, which just got a big boost from the recent announcement by @moderna_tx at @myESMO.

We are excited to share a timely perspective on this topic with @TheVinodLab & Zach Sethna the Olayan Center for Cancer Vaccines @MSKCancerCenter out now in @Cancer_Cell. We discuss the theoretical basis of neoantigen quality, which alterations in a tumor the immune system targets, within the theory of what is nonself. This topic has been one of discussion for us for over a decade.

Several paradoxes emerge, in particular, that viruses inhabit spaces close to self. So the immune system likely surveils close to self antigens, like we see in cancer, in order to fight viruses which exert strong evolutionary pressure (shout out to @JonAvramLevine & @andimscience). A model which captures one can therefore inform the other.

Lots of work to do! Enjoy the work below 👇👇👇

https://t.co/evKAlhEUmj

PS - If you like science of this sort and are looking for a postdoc consider our Theory Group effort at @MSKCancerCenter: https://t.co/FRcVCF8qUP

[Andreas Tiffeau-Mayer @andimscience]

When comparing clusterings, what makes a better solution?

In a new preprint, I describe homogeneity–parsimony curves as a means to quantify the underlying trade-off. Think of it as an ROC curve, but for clustering validation.

https://t.co/zmYVnVPjfG

[Andreas Tiffeau-Mayer @andimscience]

One month until London Q-Immuno Day 2026! 🧬💻

Join us on May 8th for interdisciplinary discussions at the intersection of theory, computation and immunology. 🥳

More details and free registration at: https://t.co/YLQAVB7pK9

[Malcolm Sim @mjwsim]

The Sim lab has been hard at work and we’re proud to present our first paper.

We developed new methods to study peptide:KIR interactions.

Congratulations to star postdoc Tanusya Murali who led the project.

https://t.co/hN0fbGOSRx

[Andreas Tiffeau-Mayer @andimscience]

More broadly, these findings might also help inform emerging protein design approaches to reduce unwanted immunogenicity

[Andreas Tiffeau-Mayer @andimscience]

How different are self and nonself? This is a central question in immunology.

In our latest work just published in @PRX_Life we demonstrate that at the peptide-level statistical differences between host and pathogen proteomes are minor

[Andreas Tiffeau-Mayer @andimscience]

An important implication for cancer treatment is that neoantigens that are just one mutation from self are not strange antigen at all, as sometimes thought.

[Andreas Tiffeau-Mayer @andimscience]

Watch out for future work in which we ask: how much spatial variability in the immune repertoire can be explained by localised clonal expansions?

[Andreas Tiffeau-Mayer @andimscience]

Excited to share the latest preprint from the lab "Fluctuating environments are sufficient to drive substantial variability in species abundance across locations" now up on arXiv https://t.co/jODwJoqzhk 🎉

[Andreas Tiffeau-Mayer @andimscience]

Our work on these questions has been motivated by our experimental findings uncovering substantial variation in the human immune repertoire across blood and tonsils. https://t.co/Gd1wxBtuhV

[Andreas Tiffeau-Mayer @andimscience]

Looking forward to connecting with many of you!

[Andreas Tiffeau-Mayer @andimscience]

If you're at @britsocimm Congress, come catch three talks today with updates about our research!

[Andreas Tiffeau-Mayer @andimscience]

Later on I will give an invited talk in the session "AI driven insights into immune responses: vaccines, infections, and disease" laying out a vision for combining AI with TCRseq to study human immunity