André

🇧🇷 Scientist! Sports enthusiast⚽🏈🏓🥋🥎🏀🎱...

[Stefan Kotschi @s_kotschi]

Happy to share our paper about localized signaling from lung cancer to sensory neurons in cachexia together with Michael Cross and @ThalesPapaG at @nyugrossman!
Thank you to @dfg_public for funding my journey

https://t.co/J9SGd5eIbS

[André @andrelq1]

@baym Here in Medford too. Shook the building! Lots of police and firetrucks crossing by.

[Michael Baym @baym]

Did anyone else in Cambridge/Boston just hear what sounded like a loud boom and rumble? Like an explosion or large object falling?

[Marcus Goncalves @MarcusDGon]

New publication from our group: what happens inside human endometrial tumors during a ketogenic diet?

We analyzed paired tumor biopsies before and after a very low-carbohydrate intervention in women with endometrial cancer 🧵

[Massimo @Rainmaker1973]

Scientists have created one of the most detailed 3D reconstructions of a human cell (eukaryotic cell) ever produced.

This groundbreaking model, often termed a "Cellular Landscape Cross-Section Through a Eukaryotic Cell," combines data from X-ray tomography, nuclear magnetic resonance (NMR), and cryo-electron microscopy to map molecular structures in extreme detail.

[Henning Langer @HenningLanger]

Super proud to share the first original research paper from my new lab:

"Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or function in obese mice and humans"

https://t.co/KgljErwtsF

[Marcus Goncalves @MarcusDGon]

The associations between resting and total energy expenditure, physical activity, and thyroid hormone levels in adult females https://t.co/luaKw7yK7Y

[Ezequiel Dantas @eze_dantas]

"Short-term fasting induces intratumoral accumulation of isoleucine, which reconfigures CD8+ T cell epigenetic programs and phospholipid remodeling, thereby licensing enhanced anti-tumor capacity."

[Iñigo San Millán @doctorinigo]

VO₂max is not the whole story.

I’ve been showing this slide for the last 15 years.
Same athlete, 2 years apart.
VO₂max? Essentially unchanged.
Performance? From average to one of the best.
What changed was lactate!.

VO₂max reflects cardiorespiratory adaptations to exercise, the size of the engine: heart, lungs, and oxygen delivery.
Lactate reflects how efficiently that engine runs: mitochondrial function, cellular metabolism, substrate utilization, and metabolic flexibility.

At the same workload, markedly lower lactate indicates greater mitochondrial efficiency and improved lactate clearance capacity. In other words, better metabolism.

In elite sport, we’ve known for decades that VO₂max does not discriminate among top performers. Many athletes share similar VO₂max values, yet those with superior mitochondrial function are the ones who win. That difference is metabolic efficiency, and we assess it through lactate testing, not VO₂max testing.

Suddenly VO₂max is being crowned as the gold standard for longevity. But metabolic health is one of the main focuses of longevity. If that is the case, the most meaningful marker should also be metabolic and Lactate provides a more precise window into mitochondrial function. Furthermore, unlike VO₂max, Lactate allows us to individualize and prescribe exercise with accuracy, something we’ve been doing with athletes for decades
#lactate #metabolichealth #longevity

[Eric Topol @EricTopol]

What does it take to achieve the highest level of human performance? Across athletics, science, chess, and music
@ScienceMagazine
https://t.co/e9EFbJyXQ5

[Rishabh @Rixhabh__]

DUOLINGO COULDN’T TEACH ME SPANISH IN 2 YEARS

ChatGPT did it in just 2 weeks.

No overpriced apps. No boring repetition. Just results.

Here are the only 6 prompts I used:👇

[André @andrelq1]

@MarcusDGon @andygraziani 👀👀👀👀😂

[André @andrelq1]

@MarcusDGon @eze_dantas Great Job!

[André @andrelq1]

@MarcusDGon @nyulangone @nyuendocrine @nyugrossman Congrats! That view just for a few...

[André @andrelq1]

@grok @Portal_Insider @grok crie uma imagem do Luva de pedreiro misturado com Ronaldo Fenômeno de topete e com o bigode e corpo do Seu Madruga.

[Physiological Reviews @physiolrev]

This review highlights the molecular mechanisms that regulate glucose utilization in skeletal muscle, the primary site of glucose storage and oxidation.

Erik A. Richter, et al.
🖱️https://t.co/21bzGXsvB8
#GlucoseMetabolism #InsulinSensitization

[André @andrelq1]

@jacobsapersonal Time todo deixou o cara chutar e ainda ficou no meio sem impedir a bola. A passividade desse time entristece.

[André @andrelq1]

@Cavalheiro1534 @centraldanacao 😂😂😂😂😂

[André @andrelq1]

@centraldanacao Popcorn, ice cream, Skittles. Brasil!

[André @andrelq1]

@MarcusDGon Literally top of the Hill!