Apurva Hendi

Combinations I like — govt & startups, culture & econ, philosophy & space, asceticism & wealth. MTS @UltrahumanHQ.

[Apurva Hendi @apurvahendi]

A meta thread of threads :-)

[Apurva Hendi @apurvahendi]

Too pure or too brazen when a man can say this on X.

[Bryan Johnson @bryan_johnson]

@Jason @ElishaDLong we've become so integrated with each other, personal and work, that my work performance has suffered. It's like I have this big gaping hole.

[Apurva Hendi @apurvahendi]

The more I read “The score takes care of itself”, the more I think it’s Bhagavad Gita’s Karma Yoga, derived from first principles — “You have a right to perform your prescribed duties, but you are not entitled to the fruits of your actions.”

[Siddha Performance @KapilGuptaMD]

For how long

Will a man allow himself to live

At levels far below

What he truly is.

[Siddha Performance @KapilGuptaMD]

When one is too close

It is blurry.

When one is too far

It is dim.

[Apurva Hendi @apurvahendi]

In the UAE, Hermes is still a store that packs overpriced orange boxes, and not an agent

[Apurva Hendi @apurvahendi]

It feels like temporary scaffolding phase managing agents. Soon we'll get tired of playing mediator and just want them talking directly to each other.

Give us a playground @claudeai?

[Sahil Lavingia @shl]

The productivity of working 1 minute every 30 minutes for 16 hours (i.e. 32 minutes) steering agents is much greater than working 8 hours a day (i.e. 480 minutes)

[Apurva Hendi @apurvahendi]

I love Slack for org comms but I cannot ignore how insidiously easy it is to waste a colleague's time on it. For starters, your mindless 'quick question' is 5 seconds for you, 30 minutes for them 🤷‍♀️

[Apurva Hendi @apurvahendi]

Every day I think I couldn't love working with Claude Code more, and every day Claude proves me wrong

[Derek Thompson @DKThomp]

This has quietly been a miracle month in medicine.

In the last 5 weeks we’ve got news on:

- retatrutide, the triple agonist GLP-1 from Lilly, basically melting fat and body-wide inflammation at record levels
- RevMed’s new pancreatic cancer drug showing unprecedented abilities to extend life
- small trial of a one-and-done PCSK9 gene editing therapy for slashing LDL cholesterol
- Mayo’s AI-assisted radiology showing vastly improved cancer detection
- this new therapy for metastatic solid tumors

This stuff is at varying levels of evidence. Retatrutide is ~100% on its way, other stuff needs more clinical trial data. But put it together and we’re maybe on the verge of majorly reducing the mortality of heart disease and cancer, the two leading causes of death in America.

[Apurva Hendi @apurvahendi]

Obsession is permission to be ruined by one thing. Obsession is finite, so it divides, not multiplies, among your interests.

Obsessed with nothing means you’ve renounced nothing.

[David Senra @davidsenra]

Rick Rubin’s House on the Mountain test:

Create according to your own taste, not for applause, critics, algorithms, or market demand.

“Imagine going to live on a mountaintop by yourself, forever. You build a home that no one will ever visit. Still, you invest the time and effort to shape the space in which you’ll spend your days. The wood, the plates, the pillows—all magnificent. Curated to your taste.”

“This is the essence of great art. We create our art so we may inhabit it ourselves.”

“I'm willing to go to extremes to make the thing that I want to inhabit and it's not for anyone else. it's just for me.”

[Crémieux @cremieuxrecueil]

Eli Lilly has done it.

They've gone and made what seems to be a powerful, permanent gene therapy for LDL cholesterol.

That means they'll be able to effectively prevent most heart disease with a single infusion!

[Apurva Hendi @apurvahendi]

There are mornings when it strikes me as the most extraordinary thing in the world that I should have a roof above me, a chair beneath me, and an hour to read a book.

[Apurva Hendi @apurvahendi]

Like animals, humans act out their nature perfectly. It’s hard to be disappointed once you truly understand that.

[Apurva Hendi @apurvahendi]

I'd been procrastinating working on something and feeling guilty about it for weeks. Just got around to doing it and took me ~30 min 🤡 Seneca was right as always: we do suffer more in imagination than in reality.

[Apurva Hendi @apurvahendi]

@Mr_Husky1 🤗

[Apurva Hendi @apurvahendi]

I wonder if "tax the rich" is really coming from the poor. The poor don't compete with billionaires. The rich are the mimetic rivals of the middle and upper-middle class, who compete with them for status, networks, housing, schools, and careers. The poor focus on immediate survival and view the rich aspirationally, rather than as rivals.

[Will Hubbard @wbhub]

Poor people: tax the rich!

Rich people: don't tax the poor

[Apurva Hendi @apurvahendi]

The Industrial Revolution gave us machines for muscle. AI gives us machines for the mind.

Jeff on AI taking away our jobs: "Imagine you've been digging out a basement for your house with a shovel, and somebody is about hand you a bulldozer. You should be so happy."

[signüll @signulll]

@elonmusk @AnthropicAI @SpaceX would you ever sell compute to openai?