Paused Polymerase synergises with transcription factors and RNA to enhance the transcriptional potential of promoters https://t.co/FRWPRv7Osq #biorxiv_molbio
What is the significance of transcription factor binding to regulatory RNA?
@DimpleNotani and colleagues @NCBS_Bangalore show that it stabilizes ERα binding to promoters with weak recognition motifs, but also reduces their transcriptional output
https://t.co/3l4O73dQRZ
New preprint from lab revealing the functional role of histone modification, H3S10p in coating active TADs for their bookmarking in mitosis. Optimal levels of H3S10p ensure promoter closing in mitosis to protect them from over stimulation post mitosis.