Deepanshu Soota

Postdoc in Holly A. Ingraham Lab, UCSF | PhD from Dimple Notani Lab, NCBS-TIFR | Interested in transcriptional regulation & hormone signaling

[Deepanshu Soota @DeepanshuSoota]

1/n: Super excited to present our work! Huge thanks to my PI, @DimpleNotani and all my co-authors: @rajat007_mann, @stupid_scholar and @Tripti2195 and @NCBS_Bangalore

[The EMBO Journal @embojournal]

What is the significance of transcription factor binding to regulatory RNA?
@DimpleNotani and colleagues @NCBS_Bangalore show that it stabilizes ERα binding to promoters with weak recognition motifs, but also reduces their transcriptional output
https://t.co/3l4O73dQRZ

[Christine Mayr @Mayr_Christine]

Finally out in @Cellcellpress!
Proteins with long intrinsically disordered regions (IDRs) are prone to misfolding during protein synthesis.
This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones.
https://t.co/Pa4bWYhOMe

[Keiichi Ito @itok10918]

Congrats to the whole team!
I'm happy that the endogenous epitope tag knock-in cell line I made helped (a tiny bit) of this work.

[nature @Nature]

Nature research paper: Transcription factor codes patterning neuronal groundplans of the cerebrum

https://t.co/R7QLGO8pIH

[Keiichi Ito @itok10918]

A Hormone Cell Atlas maps the human endocrine system at cellular resolution | Science https://t.co/DSg0to5eII

[Richard Jenner @RegGenomics]

Does PRC2 interact with RNA or is it an artefact? See our preprint showing how stringent denaturing purifications with spike-in controls support direct interaction between PRC2 and RNA in cells. https://t.co/RwMWdPpROk

[Arun Chakravorty @ChakraArun]

Our paper is finally out in Cell! Years of work on one of biology's most beautiful tissue clocks, and finding an intrinsic oscillator that helps organize tissue dynamics. From my PhD work at @LongCai_Lab, with Shosei Yoshida and Ben Simons!
🧵(1/10)
https://t.co/fRFxG3rbo2

[John Lukens @LukensJohnR]

Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-gonadal axis https://t.co/cBAzYAQv9V @ScienceMagazine

[NYU Pain Research Center @NYUPainResearch]

A newly identified spino-brain-spinal cord loop linking the thalamus, somatosensory cortex, and superior colliculus to descending RVMSC neurons specifically drives chronic mechanical pain, and may offer new cellular targets for intervention. #PainResearch https://t.co/urdGRrf9up

[Ryuta Koyama @ryuta_koyama]

Enhancers that direct gene expression to central nervous system vascular endothelial cells in vivo: Neuron https://t.co/xnWxQwVUHC

[nature @Nature]

Motherhood induces transcriptional changes in the brain that endure beyond short-term hormonal shifts

https://t.co/DIQcAVzKQ4

[Bertoglio lab (FMC/UFSC) @bertogliolab]

Astrocyte glucocorticoid receptor signalling restricts neuronal plasticity
https://t.co/8mHnCqEAX5

[BryanRoth @zenbrainest]

Cool!
Dopamine drives persistent remodelling of the maternal brain
https://t.co/sYiaCUVlcu

[Arpit Sharma, PhD @arpit_science]

Our paper just went live on @NatureAging. Peroxisomes are understudied & regarded as organelles with functions ancillary to those of the mitochondria. We shift this paradigm by demonstrating how peroxisomes actively guide organelles cascades & maintain them to drive healthy aging

[plasmidsaurus @plasmidsaurus]

🧬 Following up on RNA-seq hits just got faster.
You can now explore detailed gene information directly inside the RNA-seq interactive results dashboard.

Hover over genes in the expression plot or volcano plot, and you’ll see a quick summary tooltip. Then, click to open a detailed info drawer with expanded gene summaries, related pathways, helpful links, and more.

No more copying gene names into Google just to figure out what you’re looking at 🎉

[Igor Ulitsky @IgorUlitsky]

Now out in @NatureBiotech ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones. https://t.co/01NroM67dK

[Marc Gozlan @MarcGozlan]

Pierre Chambon, pionnier de la biologie moléculaire, est mort.
Il avait accumulé de brillantes distinctions et signé plus de 900 publications. Il s’est éteint jeudi 7 mai à l’âge de 95 ans.
https://t.co/qGQ79hqDkK #génétique

[nature @Nature]

Nature research paper: Lineage and organ signals sequentially build organ intrinsic nervous systems
https://t.co/V87bLVLjsR

[nature @Nature]

Half of laboratory mice are not what scientists think they are

https://t.co/XpqxZpLulD

[nature @Nature]

Depletion of sex hormones that enable male development induces neuroinflammation that disrupts hormonal signalling and immune responses against brain tumours

https://t.co/nDwYngPtuY

[Christine Mayr @Mayr_Christine]

If you want to know what 3′UTRs with long conserved sequence stretches do, check out our BioRxiv preprint https://t.co/ZpGfAnjAYV.

They form functional intermolecular 3′UTR-3′UTR interactions that enable co-folding of proteins to rapidly induce transcriptional programs.