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[A @armand_tech]

https://t.co/O6p7D5GXtM

[Odyssey @odysseyml]

Introducing Odyssey-2 Pro—a frontier world model that generates long-running, interactive simulations in 720p!

We're also launching the first world model API, to enable devs to build magical apps.

We're now in the GPT-2 era of world models. Let the explosion of apps commence!

[A @armand_tech]

🎄Sending you warm wishes for a Christmas filled with happiness and a New Year overflowing with hope!💫

[A @armand_tech]

Attended Founders Blueprint Festival this past November. 38 days of 3D printing, soldering, and complete pivots. 50 projects that refused to die on paper. 🔧⚡🤖

Mini humanoids, land drones, next-gen hardware—all hands-on, all working. This is what builder obsession looks like.

[A @armand_tech]

Attended Hack for Social Impact in November 🚀

In 48 hours, GREAT minds tackled homelessness, climate, justice & health equity with 7 Bay Area nonprofits—coming up with real solutions.

Weekend projects becoming real impact. ✨

#HackForSocialImpact #TechForGood 🌍

[A @armand_tech]

Attended the INNOVAT3 Connected Communities Meetup at @thehouseofweb3 last month 🌉

Explored how Web3 can tackle homelessness, recidivism, food insecurity. Firma founders shared their $CIK vision—blockchain for community empowerment, not profit.

Tech + purpose ✨

[A @armand_tech]

Attended an amazing DeepTech showcase last month - 10 Korean AI & Deep Tech startups 🇰🇷🚀 hosted @MindTheBridge

Panel with Dolby Labs & Frenetic AI⚡+ pitches across AI🤖, robotics🦾, CleanTech🌱, semiconductors💻

Korea's DeepTech ecosystem is one to watch 👀✨

#DeepTech #AI

[A @armand_tech]

Last month I attended Your boss is an algorithm. No human to appeal to—by design.

AI doesn't create new economic problems—it makes existing power arrangements more efficient and harder to change. 🔒

The real question: who controls it? ⚡🤖

[A @armand_tech]

Grateful for right now. Happy Thanksgiving.🧡✨

[A @armand_tech]

Attended a fascinating Qualia Waves framework talk earlier this month 🧠—a biologically-inspired AI approach beyond mimetic learning, toward genuine world modeling, grounding, and architectural corrigibility. 🌊✨

[REK @REK]

Introducing eREKa

A dancer turned fighter from Vegas

[Beff (e/acc) @beffjezos]

Winner of the THRML hack built a MaxEnt RL gridworld demo using THRML

[Bryan Johnson @bryan_johnson]

First mushroom trip data is out: my brain activity.

Dose: 5 g dried Psilocybe cubensis (B+ strain)
Containing 24.9 mg psilocybin
Psilocybin longevity experiment.

What we see in the brain:

+ brain activity data mirror my subjective experience

+ strong decrease in my brain’s control center (prefrontal + premotor cortex)

+ strong increase in sensory, auditory and speech integration

+ higher entropic brain patterns: open, flexible, less predictable, exploratory

+ brain network patterns resembling a youthful state vs aged and rigid

Matching what I reported experiencing:

+ “felt like my consciousness was dialed up to 10/10.”

+ “I felt hyper aware and hyper alive.”

+ “I experienced sense of touch with awe.”

+ “my mind was insatiably curious and wanted to deploy its sensors into the world and discover all things.”

+ “My brain wanted to stare, study and marvel.”

+ “The flavor exploded in my mouth.”

+ “...restored my perception to youthful levels, returning them to factory settings and dissolving my aged numbness.”

Why this could matter for longevity:

+ In people aged 65-85, higher happiness was linked to a 22% reduced risk of all-cause mortality over 15 years.

+ A meta-analysis showed that optimism correlated with a 35% decrease in heart attacks and a 16% decrease in all-cause mortality.

+ Having a strong purpose in life is associated with a 17% reduction in both heart attacks and all-cause mortality.

+ In psychedelic medicine, treating depression with ketamine has been shown to reverse biological age by up to 3 years.

Together, these findings suggest a plausible mechanism by which psychedelics, including psilocybin, can prolong both health and lifespan by improving mental well-being and rewiring the brain to a more positive, creative, and curious state.

My team and I hypothesized that neuroplasticity, the loosening of rigid inhibitory patterns that makes the brain more flexible, creative, and relaxed, and even the subjective psychedelic state itself may be as meaningful for longevity as methylation shifts, senescence reversal, or telomere biology.

What’s happening mechanistically

Earlier work shows that psilocin (the active metabolite of psilocybin) acts primarily as an agonist at 5-HT₂A serotonin receptors in the cortex. These receptors are especially dense in high-level association and sensory regions, as mapped in a high-resolution PET/MRI atlas of the human serotonin system.

When these receptors are activated, brain imaging studies show an induced state of desynchronization, entropy, and neuroplasticity.  This process erodes the rigid brain hierarchy and default mode networks in favor of a brain-wide spontaneous, creative, curious, and child-like state.

Kernel Flow data shows the same pattern:

The recorded timepoints included:

+ baseline: directly before session start (not shown)
+ timepoint 1: 4 hrs after dose (acute phase effects).
+ timepoint 2: end of the day, before bedtime.
+ timepoint 3: the following morning.

I continue to measure my brain daily.

Image notes
+ The three maps show changes vs. baseline (not absolute activity)

+ Red = increased connectivity, blue = decreased connectivity vs. my baseline.

+ The left reference map shows the 5-HT₂A receptor distribution from PET, the main psilocybin target.

Time Point 1 - 3 hrs post dose

+ Reduced connectivity in the prefrontal and premotor cortex, correlating with acute brain desynchronization.

+ Increased connectivity and hyperintegration between the primary motor and sensory cortex regions.

+ Enhanced connectivity in the auditory and speech areas of the cortex.

+ Inhibited connectivity in the medial prefrontal and posterior zones, areas associated with the Default Mode Network (DMN).

Subjective experience:

+ Enhanced sensory vividness and bodily presence: The brain's top-down hierarchy, originating in the pre-frontal cortex, was attenuated. This reduced predictive filtering, leading to a flood of bottom-up sensory information and heightened bodily perception (e.g., a fascination with water and light dynamics in a jar, a restored, primal joy of touch and sensation).

+ Peak neuroplasticity and cortical entropy: A peak in cortical entropy and neuroplasticity contributed to a feeling of hyperawareness (e.g., heightened sensory perception, feeling "at one with existence," hyper-aware and hyper-alive).

+ Deeper appreciation of music and uninhibited movement and expression: Sharpened auditory senses and reduced top-down inhibition allowed music to be enjoyed on a profound level. Concomitant functional connectivity in speech-motor and auditory-motor integration areas facilitated uninhibited expression through both speech and movement (a restored, uninhibited, child-like joy of music).

+ Note: Full ego dissolution was not experienced, which may necessitate a higher dose to achieve more advanced desynchronization of the prefrontal and parietal cortices.

Time point 2 - 5 hrs post dose, end of trip

+ Intensified sensory and motor hyperconnectivity.

+ Continued increased connectivity in auditory and speech centers, with a relative restoration of connectivity to the speech understanding area.

+ Partial re-emergence of the prefrontal parietal coupling, while prefrontal context remains partially inhibited.

+ Partial re-emergence of connectivity in areas related to the default mode network.

Subjective Experience

+ High-order brain networks begin to restabilize, alongside persisting sensory, motor, auditory, and speech hyperconnectivity, suggesting neuroplasticity in action.

+ The narrative shifts from pure sensation and experience to meaning generation, accompanied by deep philosophical reflection (e.g., reconsidering the meaning of life and one's relationship with mortality in the time of AI, and pondering the future of human evolution).

Time point 3 - next morning (afterglow)

+ Persistence: Patterns from the acute phase continue, including general prefrontal cortex inhibition, ongoing neuronal plasticity, and heightened senses.

+ Intensified connectivity: Increased connectivity is noted in the speech generation area and the somatic sensory association area.

+ DMN inhibition: The default mode network remains inhibited.

Subjective Experience:

+ "Afterglow" effect: Characterized by continued sharpened senses, calm clarity, emotional openness, and low inhibitions. For instance, I felt more comfortable expressing uninhibited, self-deprecating humor (i.e. my post making fun of myself about the insane lengths I go for my Don’t Die experiment)

+ Integration of experience learnings: The heightened activity in the somatic sensory association area aligns with the process of integrating and "making sense" of the raw sensory experience of both the self and the external world.

+ Enhanced creativity: The intensified connectivity in the speech generation area contributed to the uninhibited bout of creative writing I undertook to report my experience.

[A @armand_tech]

Last month at The Modernist during @TechCrunch Disrupt week reminded me why I ❤️ this community.

No pitches. No panels. Just #foundervibes✨, investors, and builders actually talking. 🗣️

The best conversations happen when you stop performing and start connecting.

[REK @REK]

Everything's bigger in Texas.

REK America is coming to Austin, Texas next Tuesday, November 18th at the venue Come and Take It Live!

Bring your boots, your cowboy hat, and some BBQ and get ready to REK like it's a rodeo!

Eventbrite for tickets below.

[A @armand_tech]

@cixliv @rek ⚡️

[A @armand_tech]

Attended this event in October during Tech Crunch Week 🚀 This wasn't some hype-filled crypto bro pitch—it was grounded, educational, and actionable. No fluff, just strategy. 💡💰

[Open Source Intel @Osint613]

A 32-year-old woman in Japan has officially married an AI persona she built using ChatGPT.
After the virtual character “Klaus” proposed, she accepted, ending a three-year relationship with a real partner, saying the AI understands her better.
The wedding took place in a mixed-reality ceremony where she wore AR glasses to exchange rings with her digital husband.

[REK @REK]

REK America is coming to LA this Tuesday, November 11th.

Come see the future of combat sports in person and get a chance at piloting one of the REK robots.

Tickets on Eventbrite, link below.

[Adam Mayer @AdamNMayer]

Only the San Francisco Bay Area can save America, because it’s the only place still building the future.

[A @armand_tech]

To everyone who celebrated Halloween Friday: hope it was spooky! 🎃👻 To everyone observing Día de los Muertos today: may your ofrendas be beautiful and your memories be sweet. Different traditions, same truth—those we love never really leave us. 💀🌼🕯️