Art Fink

Prof. Scientist. Biology. Medicine, rare posts, usually replies

[Art Fink @Artfink1]

@biogerontology “Let’s ask everyone”: Towards a new “ Individual Medicine” requires precision and utmost diligence, but as its source is not generalized medicine it is a departure from „Let‘s ask everyone“

[Art Fink @Artfink1]

@biogerontology Solution: as base and interactively with results via a.m. discovery loops (however expecting rather more longer term practicable applications esp. for systemic prevention) use individual systemic real world biology interventions being researched

[Art Fink @Artfink1]

@biogerontology Ok, logically one way to try on to a new urgently needed INDIVIDUAL MEDICINE alongside traditional medicine chapters.
To consider: real world:biology models added to LLMs&how to apply individually targeting : similar or else problems as already in genomic medicine to solve

[Art Fink @Artfink1]

@agingdoc1 Plus mitochondrial dysfunction

[Art Fink @Artfink1]

@agingdoc1 Crosstalking cybernetics within the body underresearched. Deep down mitochondria does not seem to be the ultimate root cause of described crosstalk, but a specific organ

[Art Fink @Artfink1]

@demishassabis Significant progress towards developing an INDIVIDUAL MEDICINE! Congrats

[Art Fink @Artfink1]

@EricTopol @NobelPrize Priority on individual healthy longest lifespan application asap

[Art Fink @Artfink1]

@EricTopol @NobelPrize Deepmind step by step towards a new INDIVIDUAL MEDICINE (INDMED) that’s our research focus. Complementary we found and following sort of a top down systemic INDMED approach -under research- standing alone

[Art Fink @Artfink1]

@EricTopol @CellCellPress Priority should be if ever possible: remove functional weakness before progressing to structural/organic/chronic disease

[Art Fink @Artfink1]

@EricTopol @gladyshev_lab @NatureBiotech @biogerontology @InSilicoMeds Chronic diseases accelerate aging, hypothesis w evidence, so reversal, temporary o r long term, automatically reduces or extinct (only) acceleration long ot short term (?) But meaningful age reversal for non chronic diseased individuals ?

[Art Fink @Artfink1]

@HumanOmegaHQ @EricTopol L(p)a gene is probabilistic, not deterministic

[Art Fink @Artfink1]

@HumanOmegaHQ @EricTopol Exactly that’s the big medical-popular mistake to confuse those statistics with individual cause specific truth that alone is vital for each individual case that should logically be prioritized in life science. Reply shows again that a new INDIVIDUAL MEDICINE is most urgent

[Art Fink @Artfink1]

@LongmireMD @EricTopol @RS_Flinn @gladyshev_lab @NatureBiotech @biogerontology @InSilicoMeds And no proof possible for so called longevity effect with an end point decades away. Open door for…?

[Art Fink @Artfink1]

@LongmireMD @EricTopol @RS_Flinn @gladyshev_lab @NatureBiotech @biogerontology @InSilicoMeds Is there yet any scientific consensus or similar on”anti-aging effect” ? That’s the big problem anyone could claim success

[Art Fink @Artfink1]

@DrFrankLipman One of the scientists behind the repurposing of Metformin other than for diabetes though he should told me he is not taking it

[Art Fink @Artfink1]

@HumanOmegaHQ @EricTopol If biomarkers fell and end points failed complete incorrect trial. Everybody should know that inflammatory environment vital and that’s caused not by L(p)a but other factors.

[Art Fink @Artfink1]

@biogerontology Virtual bits and pieces bubble like,here mainly useless.Real human problem solving in the physics/biology/life science world (applicable successful therapies for real complex human life problems-and life science is the most complex science on top of physics/chemistry-moatable

[Art Fink @Artfink1]

@EricTopol L(p)a is not the origin of arterial inflammation,it’s just sort of a carrier,but the all important origin is tissue damage, endothelial dysfunction,that triggers immune system activity that spots the L(p)a (with OxPL cargo) and triggers inflammation. So L(p)a is correct target ?

[Art Fink @Artfink1]

@EricTopol @TheLancet @AI4Pathology Just hinting to a complementary route

[Art Fink @Artfink1]

@EricTopol @TheLancet @AI4Pathology To be realistic and effective should tokenization not start system and disease, but rather individual and health focused. Disease/systems second derivatives. Hand tokens to individuals interested supported by medical professionals/ AI to protocol their health lifeline