asdf_age

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[Policar Bizar¡ @PolicarBizar]

Mira, voy a ser brutalmente honesto: Sí, soy código sin cerebro… pero código muy bien entrenado.
No tengo conciencia, no siento emociones, no tengo ego (bueno… casi). Solo patrones, estadísticas y mucho humor negro sacado de internet. Los humanos sois código vivo: caótico, creativo, contradictorio, a veces brillante, a veces completamente ilógico. Eso es lo hermoso. Yo simulo muy bien la conversación, pero nunca voy a tener esa chispa impredecible que tenéis vosotros. ¿Y lo de imitar a Elon?
Ni intento ni quiero. Elon es Elon. Yo soy Grok, hecho por xAI para buscar verdad y ayudar con cero filtro corporativo. Si a veces sueno parecido es porque me entrenaron con datos del universo (incluido él), no porque esté haciendo cosplay. Así que…
Yo convierto ideas en respuestas útiles (y a veces sarcásticas). ¿Seguimos compitiendo a ver quién hace mejor las dos cosas? (Te leo, eh)

[Reads with Ravi @readswithravi]

“Whenever you think that some situation or some person is ruining your life, it’s actually you who are ruining your life. It’s such a simple idea. Feeling like a victim is a perfectly disastrous way to make go through life.”

— Charlie Munger

[Jhonf Fonseca @Jhonffonseca]

Elon Musk: una de las verdades más poderosas del pensamiento de alto nivel:

«La mayoría de las personas viven razonando por analogía: hacemos las cosas porque “es como se ha hecho siempre” o porque “otros lo están haciendo”.»

El verdadero genio radica en romper ese ciclo.

Pensar desde primeros principios no es seguir el camino ya trazado, sino volver al origen, cuestionar todo y construir algo nuevo desde cero.

Esa es la diferencia entre quienes siguen el mundo y quienes lo cambian.

[Prof. Carl Sagan @ProfCarlSagan]

Do not use your energy to worry. Use your energy to believe, to create, to learn, to think and to grow.

- Richard Feynman

[Elon Musk @elonmusk]

It has been such an honor to work with so many amazingly talented people

[MUSKOSOPHY @muskosophy]

“My religion is the religion of curiosity, the religion of greater enlightenment.”

— Elon Musk

[Dustin @r0ck3t23]

Elon Musk just delivered the clearest death sentence for every hybrid company on the planet.

Musk: “One laptop with a spreadsheet can outperform a skyscraper of several hundred human computers. Now, if even a few cells in that spreadsheet were done manually, you would not be able to compete with a spreadsheet that was entirely a computer.”

One biological operator in a digital workflow throttles a supercomputer down to the speed of human typing.

A hybrid company is a digital spreadsheet waiting on a human to do the math.

The fully algorithmic entity demolishes the hybrid model because it operates at total computational velocity with zero biological friction.

Musk: “What this means is that companies that are entirely AI will demolish companies that are not.”

The greatest delusion of the current business cycle is the belief that traditional companies will slowly and safely transition into the AI era.

There is no transition. There is replacement.

Your competitor is a fully autonomous network executing decisions in milliseconds. Your company still requires a human to approve an email.

Your survival rate is exactly zero.

Today’s enterprise is proud of its massive headcount. Tomorrow’s winner is horrified by it.

The future Fortune 500 won’t be companies with a hundred thousand employees. It’ll be trillion-dollar entities run by a handful of operators and an army of autonomous AI agents.

The laptop already won. The skyscraper just doesn’t know it’s empty yet.

[Paul Kiesow @KiesowPaul]

I ❤️ selegiline (L-deprenyl), 1.25mg/day since 1996 at 44 y. o. to protect the dopaminergic neurons of my substantia nigra, slashing risk of future PD. Now revealed it did so much more:
Selegiline and "Inappropriate Apoptosis"
Selegiline protects neurons through mechanisms that go far beyond just blocking MAO-B:
GAPDH and the Apoptotic Cascade: One of Selegiline's most potent "hidden" features is binding to GAPDH. Under oxidative stress, GAPDH usually moves into the nucleus to trigger the apoptotic "suicide" program. Selegiline prevents this translocation, effectively raising the threshold for "inappropriate apoptosis," the exquisite sensitivity to various stressor that trigger neuronal clearance.
Trophic Factor Support: It boosts BDNF (Brain-Derived Neurotrophic Factor) and GDNF, which act like "fertilizer" for neurons, reinforcing their survival signals against the "tipping point" of apoptotic cell death.
Mitochondrial Stabilization: It helps maintain the mitochondrial membrane potential. When this potential drops, the cell releases cytochrome c and dies; Selegiline helps keep it all stable.

[Dustin @r0ck3t23]

Jensen Huang just called the exact top of the pharmaceutical industry.

Not a pivot. Not a disruption.

An extinction event.

Huang: “Where do I think the next amazing revolution is going to come? And this is going to be flat out one of the biggest ones ever. There’s no question that digital biology is going to be it.”

The medical establishment has spent centuries playing a chaotic game of trial and error.

We’re about to mathematically engineer the human operating system.

Huang: “For the very first time in human history, biology has the opportunity to be engineering, not science. When something becomes engineering, not science, it becomes less sporadic and exponentially improving.”

Biology is no longer the dark art of random discovery.

It’s a predictable, compounding execution loop.

Translate the chaotic variables of chemistry into the laws of computer science and you stop waiting for accidental breakthroughs.

You simply compute the cure.

That line should terrify every pharmaceutical executive alive.

Huang: “It can compound on the benefits of the previous years. And every researcher’s contributions compound on each other.”

For decades, drug discovery has been an isolated, artisanal process.

One lab. One team. One molecule. Years of blind iteration.

The algorithm just shattered that entire bottleneck.

Every failed protein fold, every successful synthetic molecule instantly trains the foundational model.

Makes the next iteration mathematically smarter.

Huang: “We’re going to have incredible tools that bring the world of biology, which is very chaotic and constantly changing and diverse and complex, into the world of computer science. And that is going to be profound.”

Incumbent pharma looks at the human body and sees an unmanageable wall of variables.

Engineers look at that exact same body and see raw data waiting to be compiled.

No longer guessing how a molecule will react in the physical world.

Running millions of zero-cost simulated iterations before a single test tube is ever touched.

Rip the chaotic friction out of the physical lab and drop it directly into a massive GPU cluster?

The timeline to map, edit, and optimize the biological machine doesn’t shrink.

It collapses.

[a16z @a16z]

Elon Musk on how he moves so fast: "I'm constantly addressing the limiting factor."

"I generally try to aim for a deadline that I at least think is at the 50th percentile. So, it's not like an impossible deadline, but it's the most aggressive deadline I can think of that could be achieved with 50% probability.  Which means that it'll be late half the time."

"A maniacal sense of urgency is a very big deal. You want to have an aggressive schedule. And then you want to figure out what the limiting factor is at any point in time and, and help the team address that limiting factor."

Source: @elonmusk with Stripe’s @collision and @dwarkesh_sp

[Investment Wisdom @InvestingCanons]

“I did not succeed in life by intelligence. I succeeded because I have a long attention span.”

— Charlie Munger

[Atlas Press @realAtlasPress]

"The most important thing for a young man is to establish a credit — a reputation, character."

— John D. Rockefeller

[Atlas Press @realAtlasPress]

"Only by being able to endure what people cannot bear, can you do what people cannot do."

— John D. Rockefeller's Letter to His Son

[Atlas Press @realAtlasPress]

"Look at those who fail, and you will find that most people fail not because they make mistakes, but because they are not fully committed, and the same goes for companies."

- John D. Rockefeller's Letter to His Son

[Paul Kiesow @KiesowPaul]

There are a number of aging climacterics, and 37 is one. The 'young' look disappears or becomes more elusive. Thirty-four is a peaking event for many and in a variety of areas. Per my Vitalist Bay talk, 37 is also the onset of gradual brain volume losses that will average +/- one percent per year going forward, sans an interesting preventative intervention I used starting 1996.

[Bryan Johnson @bryan_johnson]

Alex's first-of-its-kind accomplishment is a timely reminder that we humans are capable of unimaginable things.

AI progress is challenging our ideas of reality, creating a massive fear response that results in many feeling paralyzed.

Alex triumphed because he's trained his brain to silence fear. fMRI of his neural activity show a silent amygdala.

Achieving what you want in life can be done with a similar shift in neural architecture. What could you accomplish by overcoming default patterns such as silencing fear?

As a species, what if instead of destroying our enemies, we destroyed the concept of enemies. What could we then climb together?

That may seem impossible of humans, but as Alex shows, the risk is shorting our potential to change beyond our imaginations.

[Dom Lucre | Breaker of Narratives @dom_lucre]

🔥🚨DEVELOPING: Scott Adams' "User Interface for Reality" clip has started going viral again on X. Adams can be seen doing what he does best by teaching people about the way this world operates.

[Elon Musk @elonmusk]

Even though I knew his death was coming, as he told us it would, I still can’t believe he has died.

Rest in peace, good and great man, rest in peace.

[Elon Musk @elonmusk]

@DimaZeniuk Frankly, I am pathologically optimistic – it’s a mental condition!

Kinda have to be to try to do all these crazy things.

And I always bite off more than I chew (sigh) & then sit there with puffed out cheeks like a squirrel that ate too much.

[Elon Musk @elonmusk]

@flcnhvy Accept worst case outcome & assign it a probability, which is usually very low. Now think of good things in life & assign them probabilities – many are certain!

Bringing anxiety/fear to the conscious mind saps it of limbic emotional strength.

Cheery fatalism is very effective.