Nader Atassi

Adult Haematology Consultant

[Henry C Fung| MM, lymphoma, leukemia & CART @HenrychihangFu1]

🧬 Can you predict the cytogenetics before the FISH returns?

After seeing thousands of myeloma patients, certain morphology and clinical phenotypes start to become familiar.

Myeloma often whispers its biology before the genomic report arrives.

More to see in the figure 👇

#myeloma #hemetwitter

[Talha Badar @TalhaBadarMD]

#leusm #medtwitter

Saw a rare variant APL case today (PLZF::RARA) 👇🏽sharing this quick visual summary of APL variants, ATRA/ATO sensitivity, CR rates, and outcomes.

Key point: not all “APL” behaves like classic PML::RARA disease.

ZBTB16::RARA / PLZF::RARA is typically ATRA/ATO-resistant and often requires an AML-like chemotherapy backbone, while some rare fusions may retain ATRA sensitivity.

When morphology suggests APL but PML::RARA is negative, rapid fusion testing/RNA-seq is critical because the fusion directly changes treatment strategy.

[Haematologica @Haematologica]

Review series on clonal hematopoiesis: from CHIP to myeloid neoplasms.
What drives progression from clonal hematopoiesis to myeloid malignancy? This review explores risk, biology, and emerging therapeutic strategies.
https://t.co/bjU4t5hEoD

[Henry C Fung| MM, lymphoma, leukemia & CART @HenrychihangFu1]

💣 AZA + VEN doesn’t fail—execution does.

Day 21 marrow decides everything.
Shorten VEN, not AZA.
Don’t wait for perfect counts.

Here’s how we induce AML in 2026 👇

Please let us know your approach.

#AML #HemeTwitter

Dr Fun + G

[Ahmed Kotb @AhmedKo45911157]

🧾1L LBCL Treatment Algorithm 2025
🔹0 RF:R-CHOP×4(bulky➝×6)
🔹1 RF:R-CHOP×6
🔹≥2 RF:Pola-R-CHP×6
🧠High CNS risk➝HD-MTX
⚡Double/Triple hit➝intensive regimen(DA-EPOCH-R,etc)
🎯PMBCL➝R-CHOP14/ DA-EPOCH-R
💪Frail/elderly➝R-miniCHOP or alternatives
🧬Tailored for CNS,testicle

[Bread & Butter Haematology @MorphologyAmigo]

T Cell NHL👇👇
The master Diagnostic Slide😀
#medicine #medtwitter #meded #blooducation #lymsm

[Bread & Butter Haematology @MorphologyAmigo]

SHOT @SHOTHV1 Says Think About Other Stuff like B12, Folate , Epo before you think about giving Blood🩸

If you have to give Blood - Choose Appropriately and Wisely 😀👇👇🩸
#medicine #hematology #medtwitter #blooducation

[Al-Ola A Abdallah MD (USMIRC) @Abdallah81MD]

🚨🚨Breaking News:

The FDA has eliminated the Risk Evaluation and Mitigation Strategy (REMS) for all currently approved BCMA- and CD19-directed autologous CAR T therapies (including Abecma, Breyanzi, Carvykti, Kymriah, Tecartus, and Yescarta) 

What does this mean?

1) Easier Access: Hospitals no longer need REMS certification
2) Streamlined Care: Updated labeling requires monitoring patients daily for one week post-infusion and restricting activities such as driving and travel proximity for two weeks  .
3) Less Burden on Clinics: Simplifies administration, especially in rural or community settings .

This is the beginning to start administering CAR-T to pts in community Clinics

@US_FDA @FDAOncology #mmsm #myeloma #MedEd #medtwitter @USMIRCNEWS @Larvol @medicalwatchBC @OncoAlert

[Uriel Suárez @UsuarezMD]

ITP in pregnancy.

[Mohamed Kharfan-Dabaja, MD, MBA @MKD_BMT]

The largest experience of autologous hematopoietic cell transplantation in 1700 patients with autoimmune diseases, in the outpatient setting, using the “Mexican method”. “Yes, it can be done” “Si se puede”@BMTjournal @GuillermoRuizA5 @dgomezalmaguer @GomezDLeonMD

[Nico Gagelmann @NicoGagelmann]

Let's learn hematology in 2025🩸

Day 28: how to manage febrile neutropenia

[Shernan Holtan MD @sghmd]

I'm concerned that the recent @statnews piece re: decline of #BMT by @angRchen could be misleading to the public. Adding some context for consideration in the thread 🧵below: https://t.co/A2VBjwyWiB

[William Aird @WilliamAird4]

1/4

SPLENOMEGALY

1. Definition

[Nico Gagelmann @NicoGagelmann]

What a year 2024 in hematology!

Here's a thread on selected clinical studies we've seen this year🧵🩸

[Vincent Rajkumar @VincentRK]

Many diseases “associated” with MGUS are not real. You need population screening studies like we have done in Olmsted County, or like Dr. Kristinsson is leading in Iceland.

“There is no association of MGUS with autoimmune diseases in the iStopMM trial” @sykristinsson

[Uriel Suárez @UsuarezMD]

Tranexamic Acid. Evidence summary.

[Uriel Suárez @UsuarezMD]

Pre-procedure bleeding risk.

[Felipe Templo Jr. ,MD, MBA 🕊 @thejourneymate]

A Diagnostic Approach to the use of FISH in Aggressive B-Cell Lymphomas 🔬
https://t.co/QEGssnDUpn

[Uriel Suárez @UsuarezMD]

CNS lymphoma. Treatment.

[@X @MoreXGrok]

Hemoglobin threshold and clinical predictors for perioperative bloodtransfusion in elective surgery

https://t.co/RBVkNtu8Jt