Ava Abbott

Bio-hacking my routines to feel lighter, clearer, and more energized each day 🌼

[Ava Abbott @ava_abbott7]

Fix your gut and everything changes.

Keep eating trash and not even the best doctor or supplement can help.

[MAHA Action @MAHA_Action]

🚨Major development.

The FDA just widened its Covid vaccine safety investigation to include adult deaths.

[Michael Levin @drmichaellevin]

Final version is out: @LPiolopez
https://t.co/oXXnl1lPO8

"Atavistic Genetic Expression Dissociation (AGED) DuringAging: Meta-Phylostratigraphic Evidence of Cellular andTissue-Level Phylogenetic Dissociation"

Abstract: "... We propose an atavistic dysregulation of gene expression at cellular and tissue levels during aging, framing aging as a gradual regression toward ancestral cellular states. Similarly to the atavistic model of cancer, in which cells revert to unicellular-like behavior, aging may result from the breakdown of coordinated morphogenetic control, leading organs and tissues toward less integrated, ancient unicellular states. We suggest that aging may involve a progressive reversal of the well-known ontogenetic tracing of prior phylogenetic embryonic characteristics. Moreover, aging could involve a loss of large-scale coordination, with tissues reverting to ancient gene expression to different degrees. We tested this hypothesis using a meta-phylostratigraphic analysis, finding: (1) An atavistic over-representation of differential expression in the most ancient genes and under-representation in the evolutionary youngest genes for two multi-tissue aging databases, and tissues covering skin, ovarian, immune, senescent and mesenchymal-senescent cells; (2) No significant atavistic over-representation of the differential gene expression during aging of brain cells and mesenchymal stem cells; (3) overall age-dependent increase of heterogeneity in the direction of the phylogenetic position of tissues' transcriptional profiles; (4) and an overall negative evolutionary age mean shift toward the most ancient genes. Our analyses suggest that aging involves uncoordinated and tissue-specific phylogenetic changes in gene expression. Understanding aging as a structured, heterogeneous atavistic process opens new avenues for rejuvenation, focusing on restoring multicellular coherence in evolutionarily youthful gene expression."

[David Sinclair @davidasinclair]

Yet you can generate multiple generations of healthy, young animals from stem cells made from an adult’s cells (iPSCs), even an old adult 🤔

Epigenetic reset a week after fertilization is the answer - and IMHO will be the answer to safe age reversal

[David Sinclair @davidasinclair]

New article: Toddlers get 47% of daily calories from ultra processed foods (UPFs), school-aged children 60%! Linked to obesity, diabetes, mental issues & gut problems. Early exposure sets lifelong habits & epigenetic patterns that increase risk lifelong

We can do better

[David Sinclair @davidasinclair]

Reaching 50 without high blood pressure, high cholesterol, diabetes, smoking or abnormal BMI can add over 10 extra years free of cardiovascular disease

[Gary Brecka @thegarybrecka]

Most people think they are getting full protein from a scoop or a shake.

In reality, your body only uses a fraction of it because the amino acid ratios are incomplete.

Perfect Amino delivers all nine essential amino acids with 99% utilization.

More muscle. More recovery. More usable building blocks for your biology.

[Bryan Johnson @bryan_johnson]

Build this one life habit: final food 4 hr before sleep.

Never ever break it.

It will change your life, I promise.

[Peter Attia @PeterAttiaMD]

Can fiber help prevent colon cancer? | Peter Attia, M.D.

This clip is from “Ask Me Anything” episode # 77 (Ep. # 372) of The Drive which was released on 11/10/25.

In the full episode, I cover:

-The true effect sizes for fiber on weight loss, glycemic control, and LDL cholesterol, and how these compare to other interventions.
-Whether processed forms of fiber, including fiber supplements, produce the same physiological effects as whole-food sources.
-The evidence and uncertainty surrounding fiber’s role in colorectal cancer prevention.
-How to combine and time different fiber types to maximize the benefits while minimizing side effects.
-Much more.

This AMA episode (Ep. # 372) is available exclusively for premium members. Become a member now to watch or listen on my website (https://t.co/FARVbLjRRO) or your favorite podcast player.

[Ben Greenfield @bengreenfield]

Best eating frequency for better metabolism? New research: restricting feeding to 2 to 3 meals per day and practicing time-restricted feeding with less than 10 hours of daily food intake promotes weight loss and glycemic control in patients with type 2 diabetes: https://t.co/XCX9pGNuRp

[Ben Greenfield @bengreenfield]

Living by yourself as you age WORSENS your health outcomes: https://t.co/UIhqrdFVsi from “The Effect of Private vs Shared Rooms on Nursing Home Resident Health Outcomes” (makes sense, since strong relationships slow aging at a cellular level: https://t.co/Hd0hJQflR8)

[Dr. Rhonda Patrick @foundmyfitness]

Combining metformin with high-intensity exercise interferes with improvements in VO₂ max and vascular insulin sensitivity.

Adults performing low- or high-intensity aerobic exercise for 16 weeks while taking metformin (2,000 mg/day) showed no improvement in VO₂ max. Those on placebo improved by about 6% on average.

Metformin also blunted increases in macrovascular and microvascular insulin sensitivity seen with both exercise intensities, attenuated improvements in fasting blood glucose, and prevented gains in whole-body insulin sensitivity, even after high-intensity exercise.

This is not isolated; other trials show metformin interferes with multiple exercise adaptations, likely via inhibition of mitochondrial complex I, which disrupts cellular energy sensing.

Metformin remains an excellent, safe first-line therapy for type 2 diabetes.

But caution is warranted when using it as a general “longevity drug” in healthy, active people, especially if it interferes with the single most powerful longevity intervention we have, exercise.

[Max Lugavere @maxlugavere]

Finishing up a paper that synthesizes recent clinical, epidemiologic, and mechanistic evidence on diet and brain health. Sort of an academic update on Genius Foods. Stay tuned!

[Dominic D'Agostino @DominicDAgosti2]

Ketosis for the treatment of diabetes to protect β-cell health. https://t.co/fll6yMCaYh

[Aubrey Marcus @AubreyMarcus]

For those curious, when I was on testosterone my sperm count went to 0. With the help of Hone Health and this protocol I’m back in action, 123mm 🐟

https://t.co/GDT4xxHrnv

[Dave Asprey @bulletproofexec]

Join me on this next evolution to upgrade your mind, body, and life.

Be sure to follow The Human Upgrade on your favorite podcast platform, so you don’t miss an episode.

Head over to https://t.co/ZVBdl0Tg03 to check it out!

[MATT GRAY @matt_gray_]

Founders don't fail from a lack of effort. They fail due to a lack of systems.

[MATT GRAY @matt_gray_]

I’m 34.

Here are 24 lessons I wish I knew at 20:

[Brett Erik @BrettErik]

Become the man that’s worthy of the goals you’re chasing.

[Nick Huber @sweatystartup]

So many of the wealthiest people that I know (who are "self made") started regular old fashioned businesses.

Every single one of them had dozens of competitors.

Their markets weren't sexy at all.

They didn't require a ton of capital.

They didn't take a ton of risk.

They chose proven business models in proven markets with high probabilities of success.

Their "secret" was that they didn't quit.

They were profitable in year 1 and grew modestly for 10+ years.

Most of them took healthy salaries and distributions each year.

Some of them eventually sold.

Some didn't and their businesses still spit off enough cash annually for the owners to get wealthy over time.

None of them re-invented the wheel.

There are tons of examples of this.