EJ Gibson

[EJ Gibson @avhoeck]

Did you try GPT4? @Lolla0x @xtrapstarr @akash230me @smartsheepdjy @IcedKnife @BCrypto2020 @pradeep9770 @JasonB10659985 @0xzube @bigimot5824 @0973396838_van @wibowoherdi1982 @ChrisGG2017 @0x0xTom

[EJ Gibson @avhoeck]

Crypto users can use GPT4 @mehran_Senator @YBakash @toyballz @YURIAGUNG9874 @GreatGrey3 @SandipC56671777 @Boon41706158 @JaysonFabian5 @RoachCartelnft @13506603wer @plipjan @filippocccc @RifandiZky24 @OliverPayeM

[Sylvie Noordermeer @SylvieNoorderm1]

Excited to share with you the first manuscript of the lab! Here, we describe a novel synthetic lethal interaction between BRCA1-deficiency and EXO1 loss. (1/7)
https://t.co/IJWLkqQaDR

[EJ Gibson @avhoeck]

So glad to see you found a nice environment in Barca to continue your research as PI in cancer genomics. Many congrats!! Looking forward to your future projects with your friends at @HartwigMedical.

[Francisco Martínez-Jiménez @fran_mj88]

Thrilled to announce that today I begin a new chapter as Junior Group leader at the @VHIO in Barcelona. My team will work in close collaboration with the @HartwigMedical studying multiple facets of tumorigenesis and its interplay with the immune system 1/4

[HCG Centre for Academic Research (CARE) @AcademicsHcg]

𝗛𝗖𝗚 𝗚𝗥𝗔𝗡𝗧𝗛
GIST a window to the world of oncology

Systemic use of chemotherapies: study spells out risk of secondary cancer

Read at: https://t.co/1O3xXIaOXu

@BSAjaikumar_HCG @theRajGore @drvishalrao @reshmalobo @avhoeck @NatureComms @UMCU_Intl @oncodeinstitute

[Nature Portfolio @NaturePortfolio]

Anti-cancer therapies are highly mutagenic to cancer cells but the mutational impact on healthy tissues remains elusive. A study in @NatureComms characterises somatic mutations in healthy colon and liver adult stem cells after chemo- or radiotherapy. https://t.co/9qsqo6mEB4

[Cancer Stem Cell News @cancerscnews]

If you missed this paper by @ewartkuijk, @ecuppen, and @avhoeck, go check it out!

🔍https://t.co/NWVEVyBSrb

[EJ Gibson @avhoeck]

Our study is now also featured on the Editors’ Highlights page -> https://t.co/qIOTWbhceh

[EJ Gibson @avhoeck]

The mutational impact 🧬of standard chemotherapies 💉💊 in healthy tissue is tissue-type specific!!

⚠️Now online at https://t.co/4XX9Xgqxwx⚠️

Together with @ewartkuijk and @ecuppen

@UMCU_CMM @Cancer_UMCU @oncodeinstitute

[IberianCitizen @IberianCitizen]

Si bien ls quimioterapias son altamente efectivas xa matar las células cancer osas, su uso sistémico tb aumenta la carga mutacional d las células madre normales responsables d la renovación dl tejido, lo q aumenta el riesgo de desarrollar segundos cánceres
https://t.co/1OQPh8xtM2

[Nature Communications @NatureComms]

@ewartkuijk @ecuppen @avhoeck et al. analyse #SomaticMutation patterns induced by anti-cancer #therapies in adult #StemCells from healthy colon and liver using #organoids and #WholeGenomeSequencing

#CancerResearch #AdultStemCells @natrescancer

https://t.co/5Gzo5DfTS8

[Eytan Ruppin, MD, PhD @EytanRuppin]

Systemic chemotherapies use increases the mutational burden of long-lived normal stem cells responsible for tissue renewal, thereby increasing the risk of developing second cancers. https://t.co/V8NrnwIuhC

[Anirban Maitra @Aiims1742]

Interesting study from @ecuppen & @avhoeck (some surprising, others not so surprising results!) in @NatureComms:
Common anti-cancer therapies induce somatic mutations in stem cells of healthy tissue
https://t.co/cZHRo6QdPy
All adult stem cells (ASCs) or ChemoRx are not the same!

[EJ Gibson @avhoeck]

The mutational impact 🧬of standard chemotherapies 💉💊 in healthy tissue is tissue-type specific!!

⚠️Now online at https://t.co/4XX9Xgqxwx⚠️

Together with @ewartkuijk and @ecuppen

@UMCU_CMM @Cancer_UMCU @oncodeinstitute

[Nature Communications @NatureComms]

@ewartkuijk @ecuppen @avhoeck et al. analyse #SomaticMutation patterns induced by anti-cancer #therapies in adult #StemCells from healthy colon and liver using #organoids and #WholeGenomeSequencing

#CancerResearch #AdultStemCells @natrescancer

https://t.co/5Gzo5DfTS8

[EJ Gibson @avhoeck]

Novel insights on the mutational impact of DNA hypomethylation. Great study from @ewartkuijk

[EJ Gibson @avhoeck]

@ewartkuijk Awesome! Well done Ewart

[Francisco Martínez-Jiménez @fran_mj88]

⚠️⚠️Amazing paper alert⚠️⚠️
Machine learning-based classification of tissue of origin for cancers of unknown primary based on whole-genome features. >90% sensitivity and specificity and highly informative feature explanation. Take a look at the tweetorial and the manuscript👇👇

[EJ Gibson @avhoeck]

CUPLR was developed within @Cancer_UMCU, @UMCU_CMM and @oncodeinstitute with financial support from #hanarthfonds.

[EJ Gibson @avhoeck]

Our work on CUP detection now online.
CUPLR, developed by @luannnguyen0, detects prim tumor type from WGS data. WGS-based DNA tests with CUPLR will improve diagnostics for cancer patients whose primary tumor is unknown, which is reimbursed in 🇳🇱 for these patients.
@ecuppen-lab

[Luan Nguyen @luannnguyen0]

Our paper titled “Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation features” is now online in @NatureComms!

@avhoeck @ecuppen

https://t.co/ISTckLyxyE

Check out the tweetorial below:

[Hartwig Medical @HartwigMedical]

Great news! We are proud to have been able to contribute to this study with our Hartwig Medical Database. Do you want to use this data, too? https://t.co/juhp3CbQfP #personalizedtreatment #cancerresearch #cancergenomics

[Anirban Maitra @Aiims1742]

The metastatic cohort data is via the Hartwig database (see Dr. @ecuppen tweetorial linked below). An incredible freely available resource for the cancer research community.