Bartek Lab

[Dimitris_Kanellis @Di_Kanellis]

We identified a ribosome biogenesis-associated gene signature with prognostic/predictive value in Acute Myeloid Leukaemia. Many thanks to all authors and our funding agencies! @Vetenskapsradet, @cancer_dk, @Cancerfonden, @cancerforskning

https://t.co/EP5Ge2gLFu

[Marián Hajdúch @marian_hajduch]

S hlubokým zklamáním upozorňuji na rozpočtové opatření schválené vládou dne 19. 11. (usnesení vlády č. 914/2025), které přesouvá z oblasti vědy a výzkumu více než 500 mil. K�� (dohromady u TA ČR, GA ČR, AV ČR a AZV/MZ) a 1 mld. Kč v rámci MŠMT (nevím z jakých zdrojů) do rozpočtu MŠMT, pravděpodobně na pokrytí nákladů na nepedagogické pracovníky ve školách, kde chybí asi 3 mld. Kč.
Tyto prostředky budou ve vědě a výzkumu velmi bolestně chybět a to i s ohledem na 30% inflaci, která v rozpočtu nebyla kompenzovaná. Pokračuje tak reálný pokles financování vědy, výzkumu a inovací v poměru k HDP.
Je to další rána vědě a inovacím v České republice, která snad nejvíce oborově postihne zdravotnický výzkum a medicínu.

[Luis Toledo @luistoledolaz]

To all colleagues - we have a nearly brand new Evident ScanR microscope for sale. Less than 100 hours of use, 60% of original price. A real bargain for the aficionados. Please PM for details

[Bartek Lab @Bartek_Lab]

The new review “The need for speed: drivers and consequences of accelerated replication forks” summarizes current understanding of how replication fork speed is regulated and why it matters.

Read here: https://t.co/Abx7dHAhKh

[Bartek Lab @Bartek_Lab]

Encouraging to see how both the science and the people have advanced. Our 2018 study showed that PARP inhibitors accelerate replication fork progression (Maya-Mendoza et al., Nature), a finding later followed up by several other labs. https://t.co/Abx7dHAPzP

[Panos Galanos @p_galanos]

Our first group method paper is out in @STARProtocols from the @bmbSDU @NATsdu, presenting a robust imaging approach to monitor de novo RNA synthesis at DNA DSBs! Huge shout-out to all co-athors and to our collaborators from the @Bartek_Lab https://t.co/6PuUoixirt

[Molecular Cell @MolecularCell]

PARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed https://t.co/wJrwwOrtp1

[altmeyerlab @altmeyerlab]

Sharing our latest work @UZH_en tracking DNA damage inheritance by Live+QIBC https://t.co/pN5Ivt8DIV. Huge congrats to @APanagopoulos_, M. Stout and all co-authors for this tour de force! Beautifully summarized by @S_J_Aitken and E. Reilly @NatureNV https://t.co/9IVexti382.

[Pavel Moudrý @3reak]

🧬 Zbývá už jen poslední měsíc na přihlášení na PhD pozici zaměřenou na výzkum replikace DNA. Přidej se k našemu týmu a podílej se na špičkovém biomedicínském výzkumu!
📍Ústav Molekulární a Translační Medicíny, UPOL Olomouc
📅 Deadline: 15.5.2025

https://t.co/Z5TGYXcl1E

[Hana Sedlackova @HanaSedlackova1]

📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! https://t.co/N643U0oS1M

[Pavel Moudrý @3reak]

Our new preprint is now on bioRxiv! 📄 We introduce qAID, an AI-based workflow for automated analysis of DNA replication dynamics. Glad to have contributed a small part to this study.

[Czexpats In Science @czexpats]

Působíte vědecky v Dánsku? 🇩🇰 Přijďte se potkat! 💫

Další ze série lokálních setkání proběhne 25. dubna na Velvyslanectví ČR v Kodani ve spolupráci s @czexpats 🤝

Těšit se můžete na keynote přednášku kognitivní neurovědkyně @HanaMalaRytter, sérii krátkých flash talků a samozřejmě spoustu networkingu 🗣️ 💬

Registrace je otevřená do 21. dubna 👉 https://t.co/PLXuWsBN9c

Budeme se moc těšit! 🙌

[Pavel Moudrý @3reak]

Looking for a PhD in cutting - edge cancer research?
Join DNA replication dynamics group at @IMTM_Olomouc @NUVR_CZ @UPOL to study PARP inhibitors - key cancer drugs - and their impact on DNA replication.
The fight against cancer starts in the lab! #PhDposition #CancerResearch

[Charles Swanton @CharlesSwanton]

We managed to get one last paper https://t.co/AwA1rYKefr over the line before the new year🥂! We are pleased to share the first Nature Cell Biology paper from our lab functionally validating the role of a frequently occurring lung cancer driver, FAT1 in cancer evolution. 🧵1/13

[Hana Sedlackova @HanaSedlackova1]

📢 Happy to share our bioRxiv preprint on how CRL4-DCAF12 regulates the cellular level of MCMBP, a chaperone of nascent MCM2-7 complexes, to ensure error-free genome duplication. The full story can be found here: https://t.co/296kJoJh1M

[Panos Galanos @p_galanos]

🚀 #Postdoc Opportunity! 🚀 Join my lab @UniSouthDenmark in the Translational Cancer Hub initiative. Dive into cellular #senescence & its impact on cancer progression & therapy resistance! Apply here 👇
https://t.co/1qCKSZuh6T

[Institute of Molecular and Translational Medicine @IMTM_Olomouc]

Important breakthrough! Our scientists have identified a new molecular target for cancer therapy, focusing on hereditary breast & ovarian cancers. Published in @NatureComms, their findings on DNA replication could lead to more effective treatments.💊https://t.co/QY9gbiDPhL

[Larsen_lab @LabLarsen]

We are very excited to share our manuscript "Hyper-recombination in ribosomal DNA is driven by long-range resection-independent RAD51 accumulation" now online in Nature Communications :-) https://t.co/69zYMHW63G

[Kenneth Bødtker Schou @Piggywedia]

Thrilled to announce our latest bioinformatic study in @NatureComms! If your interests are genome maintenance mechanisms in mitosis or DNA repair check out this rich resource of new genome maintenance candidates https://t.co/YjcEe8YwOq
#dnarepair #replication #AlphaFold #Cancer

[Bartek Lab @Bartek_Lab]

Have you ever wondered which DNA polymerases are responsible for accelerated replication forks?

[Pavel Moudrý @3reak]

Huge milestone for my team, uncovering DNA polymerase α-primase role in PARP inhibitor-induced replication fork acceleration. Designed and conducted at @IMTM_Olomouc @NUVR_CZ @UPOlomouc https://t.co/ZWkWrr6huh