Basri Gülbakan

Doç.Dr. Hacettepe Üniversitesi @hacettepe1967, Çocuk Sağlığı Enstitüsü, Çocuk Metabolizma Lab., || Alumnus: @UF, @ETH

[NEJM @NEJM]

A new article describes gene editing in a mouse model of a peroxisomal disorder, as well as the broader landscape, including regulation, of the treatment of rare genetic disease through gene editing.

Learn more in the Clinical Implications of Basic Research article “Gene Editing, Peroxisomal Disorders, and Treatments for Rare Disease” by Rebecca C. Ahrens-Nicklas, MD, PhD: https://t.co/knYICPUc6f

[Martin Picard @MitoPsychoBio]

The cycle of life, every instant, in your mitochondria.

The major electron carrier in mitochondria is NAD+. When it collects an electron from the food you eat, NAD+ is converted into NADH. NADH then feeds the electron to the electron transport chain so the electron can flow to oxygen - the ultimate electron acceptor.

How easily electrons make their way to oxygen determines energy resistance (éR) following the energy resistance principle (ERP) https://t.co/eAL6i73l09

Mitochondrial matrix and cell cytoplasm are two different "sealed" compartments, but there is a special system that connects the NAD+/NADH pools between mito and cytoplasm: the Malate-Aspartate shuttle

The Malate-Aspartate shuttle shown below is how NADH from the cytoplasm (made by glycolysis) is carried into mitochondria. The electron transport chain can then regenerate NAD+ by respiring the flowing electron.

Everywhere in biology: energy transfer. Sometimes without molecular carriers. Here with a number of enzymatic intermediates, creating an integrated electrical circuit.

The circuit is in service of the flowing electron looking for a place to rest. Getting back onto oxygen to become H2O (water) again, as it was initially before getting ripped off by light energy and stuck onto a carbon backbone in a green leaf.

Animation by @janetiwasa lab
https://t.co/V7R07dVJbi

[The New York Times @nytimes]

This traditional Turkish egg dish of garlicky yogurt with poached eggs and a drizzle of spicy butter is rich, luscious and faintly smoky. https://t.co/H7dZlrbTmq

[The Nobel Prize @NobelPrize]

Carolyn Bertozzi – awarded the 2022 #NobelPrize in Chemistry – has taken click chemistry to a new dimension and started utilising it in living organisms. Her bioorthogonal reactions take place without disrupting the normal chemistry of the cell.

[The Nobel Prize @NobelPrize]

BREAKING NEWS:
The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”

[Nature Biotechnology @NatureBiotech]

The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants https://t.co/tnTN0N1V8M

[nature @Nature]

Nature research paper: A DNA origami rotary ratchet motor https://t.co/MzaFwRTUKf

[Sapient @SapientBio]

A study recently published by PNAS used blood-based untargeted #metabolomics to identify four perturbed metabolic pathways in patients with relapsing-remitting #multiplesclerosis & revealed a testable therapeutic target for developing potential therapy: https://t.co/w8jQ6qTWn8

[Journal of Biological Chemistry @jbiolchem]

Introducing your 2022 #JBCMethodsMadness Champions — #TeamMassSpec 🏆

[Türker KILIÇ @turkerkilic]

Nature’da yıllardır merakı içinde olduğum çalışma yayınlandı👇
Zekânın normal beyin anatomisine sahip bireylerde, genetik yapı ile ilişkisi olmadığı;
bugünkü teknolojimiz ile elde ettiğimiz bağlantısallık MR görüntüleri ile de ilişkisiz olduğu belirlenmiş.

[Cell Metabolism @Cell_Metabolism]

Metabolite discovery: Biochemistry’s scientific driver https://t.co/Mj1wPZKvmg

[Nature Methods @naturemethods]

It’s finally here!! Our Method of the Year 2021 is….Protein Structure Prediction!!
https://t.co/jZsL70fAkz

[Luke O'Neill @laoneill111]

6 separate lab-based studies all concluding that Omicron is less able to infect lung cells which supports current indication that Omicron is less able to cause severe disease.

Table by @EricTopol

[Prof. Feynman @ProfFeynman]

Students don't need a perfect teacher. Students need a happy teacher, who's gonna make them excited to come to school and grow a love for learning.

[Basri Gülbakan @basrig]

https://t.co/9usnhARZp7

[Prof. Feynman @ProfFeynman]

The difference between Knowledge and Experience.

[Nature Methods @naturemethods]

HERMES: a molecular formula-oriented and peak detection-free method. HERMES uses LC-MS1 information to optimize MS2 acquisition for LC-MS-based metabolomic analysis. @GineRoger @yaneslab @ciberdem @universitatURV @IISPereVirgili
#metabolomics
https://t.co/7AIbgT5JdE

[Pediatric Research @Ped_Research]

Metabolic control during the neonatal period in phenylketonuria: associations with childhood IQ
https://t.co/bNWzXr6sOF

Phenylalanine-levels during were clearly & negatively related to later IQ, whereas no significant associations were observed for other indices

[Nature Medicine @NatureMedicine]

Protein structures predicted by Alphafold @DeepMind will aid medical research, but the greatest benefit will come if clinical data can be similarly used for #AI.

Comment from Janet Thornton @emblebi and colleagues

https://t.co/Ew3uvWQtSz

[Prof. Feynman @ProfFeynman]

Equations that changed the world. 🧠