Dongsheng Bai

Postdoctoral Associate @chenxuzhu' Lab @nygenome | Alumni @YiChengqi's Lab PKU | Chemical biology, Epigenetics | Single Cell Multi-omics, Spatial-omics

[Dongsheng Bai @bds1993]

🥳AIM goes beyond single-site editing. By introducing a controllable editing window, AIM enables precise, multi-site, and multi-functional base editing within a targeted RNA region, expanding the capabilities of RNA editing tools.🧬📝@zhuangyuaner

[Nature Biotechnology @NatureBiotech]

Single-strand deaminase-assisted editing for functional RNA manipulation - @YiChengqi @PKU1898 https://t.co/ygODPGrwMl

[Nature Methods @naturemethods]

Paired-Damage-seq is an in situ labeling-by-repair strategy for joint profiling of oxidative and ssDNA damage alongside gene expression, in single cells.

https://t.co/vvCR8VkLhN

[Nature Methods @naturemethods]

And read the Research Briefing here, for a quick summary:

https://t.co/JNOhBY0lgh

[Dongsheng Bai @bds1993]

📣Excited to share our latest work, Paired-Damage-seq, online now @naturemethods ! Huge thanks to @chenxuzhu @ZKCao27, and all lab members!🧬

[Chenxu Zhu @chenxuzhu]

We're incredibly excited to share our new method, Paired-Damage-seq, out @naturemethods today! This technique allows us to jointly analyze oxidative DNA damage and SSBs with RNA, all at the single-cell level (1/5). https://t.co/epPZuVC1jA

[Nature Reviews Genetics @NatureRevGenet]

Methods and applications of genome-wide profiling of DNA damage and rare mutations https://t.co/fIqMLVn6tm #Review by @gppfeifer & @VAInstitute
Free to read here: https://t.co/czgb1FfiXe

[Nature Biotechnology @NatureBiotech]

SIMPLE-seq to decode DNA methylation dynamics in single cells #NRGToT via @NatureRevGenet https://t.co/EiXQFoIlmB

[Dongsheng Bai @bds1993]

Excited to kick off the "ToolsOfTheTrade" series @NatureRevGenet with our SIMPLE-seq! SIMPLE-seq offers a solution for the single-cell analysis of the relationship and dynamics of 5mC and 5hmC in various biological systems. 🧬

[Nature Reviews Genetics @NatureRevGenet]

Our first #ToolsoftheTrade article has just been published https://t.co/AZOBS5UrEv
Dongsheng Bai (@bds1993) and Chenxu Zhu (@chenxuzhu) @nygenome wrote about SIMPLE-seq to decode DNA methylation dynamics in single cells (based on their @NatureBiotech paper with @YiChengqi)

[Dongsheng Bai @bds1993]

Huge congrats to @Jinghui_Song @zhuangyuaner @YiChengqi 🥰

[Jinghui @Jinghui_Song]

Programmable RNA base editing via targeted modifications | Nature Chemical Biology https://t.co/8VE4IOYYdn

[Dongsheng Bai @bds1993]

@zhuangyuaner 🥰🥰🥰

[Chengqi Yi @YiChengqi]

SIMPLE-seq @NatureBiotech developed by Dr. Dongsheng Bai @bds1993 et al. that simultaneously detects 5mC and 5hmC at the single-cell and single-molecule level!
Jointly published by Prof. Chenxu Zhu @chenxuzhu from Cornell University and us.
https://t.co/BkLjbajyx3

[Dongsheng Bai @bds1993]

We use orthogonal chemical reactions and novel recording strategy to detect the two most important DNA modifications at single-molecule level and to track the dynamic of DNA methylation across heterogeneous samples. Full manuscript here: https://t.co/tFYAAOONFm

[Dongsheng Bai @bds1993]

Thrilled to share our latest research, SIMPLE-seq, a high-throughput single cell method enabling simultaneous profiling of 5mC and 5hmC. Our SIMPLE-seq work is online now @NatureBiotech! Huge thanks to the exceptional mentor @YiChengqi @chenxuzhu, and all lab members!

[Nature Biotechnology @NatureBiotech]

Simultaneous single-cell analysis of 5mC and 5hmC with SIMPLE-seq - @PKU1898 @chenxuzhu @YiChengqi https://t.co/C56mkquJQj

[Dongsheng Bai @bds1993]

燕园再会😜~

[Peking University @PKU1898]

#PKU wishes all the graduates a bright future. (Photos: Chen Ziyue, Zhang Haoran, Zhong Jielan) 2/2

[Dongsheng Bai @bds1993]

Tet3 helps to reform🤰🧬👶 https://t.co/0se5hkmDj6

[Dongsheng Bai @bds1993]

the green power💵's gambit with Death

[MIT Technology Review @techreview]

Meet Altos Labs, Silicon Valley’s latest wild bet on living forever. Funders of this deep-pocketed new "rejuvenation" startup are said to include Jeff Bezos and Yuri Milner. https://t.co/dPyfa9hV4Y

[Dongsheng Bai @bds1993]

efficient damage repair, the art of long life span🐟

[Science Magazine @ScienceMagazine]

This week in Science: A genomic analysis of 88 species reveals the genetic underpinnings of rockfish life spans, which range from 11 years for the shortest-lived species to >200 years for the longest.

Read that study and more in our latest issue: https://t.co/WhhXYiBAz2

[Nature Chemical Biology @nchembio]

A new paper from @zhuangyuaner @JoAnneLIU_abc @HaoWu_pku @YiChengqi @PKU1898 reported an improved prime editing method using paired guide RNAs that enables efficient editing in human cells. Free to read: https://t.co/vtIlqMyYsS https://t.co/DbMEFLwI5Z

[Dongsheng Bai @bds1993]

Excited to share new paper from @YiChengqi lab, huge congrats to @zhuangyuaner 🥳🥳🥳 #PEMonth

[Yuan Zhuang @zhuangyuaner]

Excited to share our paper out now @nchembio! (1/2)
https://t.co/RHlXLtEPub

[Dongsheng Bai @bds1993]

HOPE your work online ASAP🥰

[Yuan Zhuang @zhuangyuaner]

Oct. is PE month!👏👏

[Dongsheng Bai @bds1993]

@zhuangyuaner HOPE your work online ASAP🥳👏