I am excited and humbled to share that I have been awarded an NCI F99K00. This fellowship will provide up to two years of funding for me to finish my PhD studying tyrosine kinase signaling networks during hypoxia, and four additional years of post-doctoral funding. 1/2
🧬 Big Data Phylogeny & Comparative Methods course (23–26 June, online)
Learn to build and interpret phylogenetic trees, analyse trait evolution, and apply comparative genomics to real data
https://t.co/gNs0pJN2Ep
🧬Collinearity Analysis is here in #gbdraw v0.11.0! You can easily detect and visualize synteny and collinearity blocks using LOSATP. You can instantly align the entire diagram based on a shared ortholog!
Try it now: https://t.co/ahqoRxbDHT
#bioinformatics#genomics#microbiology
📣Nominations are now open for the following awards:
-Outstanding Postdoc at Duke (nominate here: https://t.co/sRcOtmRBY6)
-Outstanding Postdoc Mentor at Duke (nominate here: https://t.co/YRK48AcGcw)
Deadline to nominate: 9/10/25 at noon
More info: https://t.co/J65ORb60sY
Read the paper featured on the cover of this month’s Cancer Discovery: PKN2 Is a Dependency of the Mesenchymal-like Cancer Cell State https://t.co/anIOqigdIU By Shane Killarney, @kcw00d, and colleagues @Duke_PCB@DukeCancer
An accomplished scientist who studies the role of protein tyrosine kinases, Ann Marie Pendergast, PhD, finds mentoring easy because she focuses on it full time. She meets weekly with students in her lab and outside of that, her office is always open.
https://t.co/GQxqGhg0LP
Exciting findings in a study led by Shane Killarney in the @kcw00d lab: Mesenchymal-like cancer cells depend on PKN2 kinase for survival, offering a potential therapeutic target against drug resistance. A cool collaboration with the Pendergast and McDonnell labs ⬇️ @DukeCancer
I'm excited to announce that I've accepted a TT faculty position @VanderbiltCDB and @VUMC_Cancer! Thrilled to join @VanderbiltU!
The Mudumbi Lab opens January 2025. We will use single-molecule microscopy to study the kinetics of RTK signaling, with a focus on biased signaling!
A farewell to our fantastic colleague, Jamie Baize Smith @katbaizes. The PCB students, staff and faculty thank you and we wish you all the best in your next chapter.
Are you ready for unpublished research on protein kinases and phosphorylation plus a gorgeous view of the Irish Coast? Join @bradylabupenn, @Megston8, @mbyaffe, and Vincent Tagliabracci @UTSWScience for this great program and save your space at #PPHSRC: https://t.co/zKcwEzC0PT
Current protein models (ESM-2, AlpaFold2,...) only encode the 20 wild-type amino acids -- what about PTMs, which significantly influence the diversity of the proteome? 💁♂️To solve this, we present the first PTM-aware protein language model, PTM-Mamba! https://t.co/2yk9mjOA6G
Our paper discovering short linear motifs #SLiMs targeted by the MAP kinases ERK and p38 is now published! Led by the incomparable Jaylissa Torres Robles, this paper resolves how these two related kinases selectively target unique substrates.
https://t.co/mtlbh6q4qM
It is not fresh to know that γ-secretases process APP to generate Aβ. But what do they cut in microglia? Why do they cut so many proteins in the meantime? Our paper just published in @MolecularCell provides new insights on these topics. Check it out: https://t.co/zRKJmt5WwH
PCB Dissertation Seminar
Breast cancer cells exhibit a non-linear proliferative dose response to progestins
Presented by: Emma Dolan
Advisors: Drs. Donald McDonnell & Susan Murphy
Friday, October 27 at 9:00am
LSRC A247