Michael Yaffe

Professor at MIT, Surgeon-Scientist. DNA damage signaling, protein kinases, precision cancer medicine, signaling in tumor microenvironment

[Michael Yaffe @mbyaffe]

@Arnab_RC1 @luijsterburglab Cool story. Had not expected Rad51 to be loaded in absence of BRCA2. Nice work. Congratulations Arnab!

[Michael Yaffe @mbyaffe]

@mbeisen @NIH Imagine if Congress passed a law where the amount a journal could charge decreased progressively from time of initial submission until time of acceptance. After 4 months, charge was zero. That would put an end to journals requiring months to years of additional experiments.

[Michael 英泉 Eisen @mbeisen]

Scientists and universities: defend indirects as a concept but not current indirect rates. Don't think there's waste in those numbers? We (US science) spend $4.5 billion on journals. That is HALF of the proposed cuts in indirects, and eliminating that spending would make science better!

[Michael Yaffe @mbyaffe]

Special thanks to Adam Palmer's lab, Matt Vander Heiden's lab, Omer Yilmaz's lab, and the folks at Genentech, all of whom were instrumental in this 5-FU story about RNA damage! Collaborative science is always the best!

[Michael Yaffe @mbyaffe]

Thrilled to share our latest story on 5-FU inducing RNA damage during ribosome biogenesis - https://t.co/yZhVYKhOQA. The whole thing started when Karl and Jung-Kuei were trying to figure out hiow limiting dNTPS skewed DNA repair. Never thought it would be RNA and tge ribosome!

[Michael Yaffe @mbyaffe]

https://t.co/s7h7TWriLx
Thrilled to share this latest work led by Xiao-Kang Lun in Peng Yin's lab and Xueyang Yu in mine. Finally, single cell signaling can begin to rival single cell RNA-Seq, using CyTOF, phospho-antibodies and ACE amplification.

[Michael 英泉 Eisen @mbeisen]

This is rich - one of the primary reasons scientists don't have a lot of time to think is that @nature and its ilk have promoted a culture where the primary goal of science is to produce bloated Nature papers that require lots of time and money, but little thought, to produce.

[Michael Yaffe @mbyaffe]

@CarrieRyanMD @OhioStateSurg @NCI_SurgOncFel @UBSurgery Congratulations!

[Michael Yaffe @mbyaffe]

@jjonkers2 Remember the good old days when Science and Nature published breakthroughs in basic science and clinical journals published patient trials?

[Michael Yaffe @mbyaffe]

@DrEricDing @SamuelBHume We used to routinely do thymectomies every time we did open cardiac bypass surgery in adults and also in pediatric cardiac surgery cases to make operative exposure easier. Was probably a bad idea.

[Michael Yaffe @mbyaffe]

@JuraLab_UCSF Thank u so much Natalia! It means a lot to me to have your support!

[Michael Yaffe @mbyaffe]

Thrilled to share our characterization of the human tyrosine kinome.
Try out the public website: https://t.co/a5zfETTzCf
Wonderful collaboration with @CantleyLab @benturklab @LabYaffe. Many years of work led by Jared Johnson!

https://t.co/UsmA3wE78P

[Michael Yaffe @mbyaffe]

@TekeMartha @UMPedsSurg @RodriguezMDNCI @dallastrauma @FiemuNwariaku @herbert_zeh @AdamYopp @JMHernandez_MD @JeremyLDavisMD @AMBlakely @MAustinPediSurg @DrDrNatasha @UTSW_PediSurg @SocietyofBAS Well done Martha!

[Michael Yaffe @mbyaffe]

@DalalSci The most important thing we do as researchers is train the next generation. In the end, it is the biggest contribution almost all of us will make to science. If you to have real impact, and influence the future, focus on your undergraduates. My undergrad mentor shaped my life.

[Michael Yaffe @mbyaffe]

This is a really important thread from Lior Pachter about the mathematical underpinnings of scRNAseq.

[Michael Yaffe @mbyaffe]

https://t.co/NVfOSmlTm4

[Michael Yaffe @mbyaffe]

@DrAnneCarpenter I have completely stopped wasting time on DoD applications. The whole process is flawed. The only reason DoD has money for biological research is a congressional mandate. Put the money into the NIH instead. Would be better managed.

[Michael Yaffe @mbyaffe]

@mbeisen At Science Signaling I would like to think that we held everyone to the same bar, but I also thought I had no implicit bias in other aspects of my life…until someone showed me that I did! Maybe we need some implicit bias training in publishing…or a “DEI” approach in future.

[Michael Yaffe @mbyaffe]

@mbeisen It either means that only the same small sets of labs are the ones consistently doing great science (which could I suppose be true), or that perhaps there is an element of implicit bias where the standards required for sending a paper out for review are not uniform.

[Michael Yaffe @mbyaffe]

@mbeisen It was my experience that most professional editors are truly trying to do the right thing…but without broad input from outside, at some point things become an echo chamber. Why else is it that a small subset of labs are able to publish in those journals again and again…