Bernard Thienpont

all things epigenetic
@KU_Leuven @CHG_CME

[Bernard Thienpont @bernthie]

🚨Super proud of a new publication from our lab spearheaded by @MarieDeBorre, together with @UZLeuven, @ZOLziekenhuis and @azsintjan. We provide proof-of-concept that cell-free DNA (cfDNA) methylome analysis allows for early preeclampsia (PE) prediction. https://t.co/rOD2fbJWrl

[Center for Human Genetics (KU Leuven - UZ Leuven) @CHG_CME]

📢 #JobAlert The research group of @bernthie is looking for a lab technician. You can contribute to various interesting research projects. Apply before 11/03:
https://t.co/LBUUPEAYiY

[ROBtv @rob_televisie]

Volg morgen en overmorgen van 10 u. tot 16 u. alle 𝟲𝟬𝟬 𝗦𝗘𝗖𝗢𝗡𝗗𝗘𝗡𝗟𝗘𝗭𝗜𝗡𝗚𝗘𝗡 tijdens @KU_Leuven Inside live op ROBtv. #robnieuws #robtv

[KU Leuven Institute for Single Cell Omics (LISCO) @KULeuvenLISCO]

LISCO is looking for an experienced Business Developer in Single-Cell and Spatial Multi-Omics for Biomedicine to take our cutting-edge lab services and research capabilities to the next level.👉 Apply here: https://t.co/hGHBfewdfb or feel free to share with your network!

[Center for Human Genetics (KU Leuven - UZ Leuven) @CHG_CME]

Researchers from the CME @UZLeuven @KU_Leuven developed a new technique that combines #genetic and #epigenetic analyses. This opens the door to faster diagnosis and more insight into the cause of #rarediseases. Covered in the national news 👇
https://t.co/IQqW0KQg29

[VIB Training & Conferences @VIBTrainConf]

Are you active in #sequencing and want to show your research to leading researchers? Submit an abstract for #RNGS25: https://t.co/8OMd3kCuBr
Present on stage with a poster pitch or during the poster sessions.
The abstract deadline is 15 January 2025.
#ngs #genomics #multiomics

[GeertCarmelietLab @GeertLab]

Many thanks @NatMetabolism for publishing and highlighting our research, all members of our lab, the excellent collaboration with @bernthie and especially first author @SteveStegen

[Sakari Vanharanta @SVanharanta]

We are recruiting PhD students in cancer and metastasis biology! This is a fantastic program that brings together several leading European research institutes. Details below 👇.

[Center for Human Genetics (KU Leuven - UZ Leuven) @CHG_CME]

🏆Congrats to our PhD researchers Mio Aerden (@bernthie lab) and Yente Monnens (@JohnCreemers lab) for winning the 1st and 2nd prize at the Genetics Retreat NVHG graduate meeting. #proud
https://t.co/94Tl1Xagmv

[Bernard Thienpont @bernthie]

@Nature amazing and important study!

[NEJM @NEJM]

Lannoo et al. examined whether rare autosomal trisomies revealed by noninvasive prenatal screening reflect fetal trisomy or confined placental mosaicism and whether they are associated with ⬆️ likelihood of adverse perinatal outcomes. Full correspondence: https://t.co/tVZE9lDcNP

[Center for Human Genetics (KU Leuven - UZ Leuven) @CHG_CME]

We have a new 'Dr. House' in the house! PhD researcher Benjamin Huremagic participated in the #undiagnosedhackathon2024. Together with a bioinformatician from @UAntwerpen solving a case in only 2 hours: https://t.co/FDqH5cdfIS
@KU_Leuven @Nieuwsblad_be @JorisVermeesch

[Bernard Thienpont @bernthie]

amazing work and thoroughly deserved by @KateEStanley1 !

[James Fasham @JamesFasham]

#eshg2024 awards 🏆
Early career award
Kate Stanley👏🏼

[Hegel Hernandez @Hegel_MD_PhD]

Nice presentation from @JorisVermeesch #BeSolveRD #ESHG024 #genomics #WGS #RareDisease

[Nature Reviews Genetics @NatureRevGenet]

@bernthie highlighting his recent multi-omics review (free to read link in quoted tweet) now at #ESHG24

[European Society of Human Genetics (ESHG) @eshgsociety]

Welcome to the last day of #eshg2024! Tune in on one of our symposia or educational sessions starting now.

[Joris Vermeesch @JorisVermeesch]

Great talk @ESHG from @KateStanly on deconvoluting cfDNA!

[Qian Cheng @sgqcheng]

.@RidderKobe @bernthie comprehensively benchmark DNA methylation-based deconvolution methods, evaluating their performance and robustness to technical bias. #BiotechNatureComms @NatureComms
https://t.co/0aU01Wvbuz

[Bernard Thienpont @bernthie]

Thanks to @ridderkobe for expertise, persistence and diligence, to other members of the lab and reviewers for their insights, and @FWOVlaanderen and @Stkstichting for support! Happy deconvolving to you all! https://t.co/VR9He2qEZg

[Bernard Thienpont @bernthie]

paper alert 🚨Figuring out the cellular composition of tissues is essential for understanding diseases. DNA methylation analysis is particularly suited for this task, as deconvolution algorithms can untangle mixture signals from bulk samples into their individual components.

[Bernard Thienpont @bernthie]

For sequencing-based DNA methylomes, we also assessed how sequencing depth and uniformity affect performance. This resulted in a nuanced set of recommendations for optimal deconvolution, depending on the underlying research question and goal.