Prem Bhattarai

PhD Candidate at Respiratory Translational Research Group (RTRG)@University of Tasmania

[Sukhwinder Singh Sohal 🫁 @Romy_Sohal]

Recent publication from our research group reporting EMT changes and effects of ICS in the lungs of patients with asthma-COPD overlap (ACO) @Sohal_LabRTRG
https://t.co/qRuK1grxXl

[Sukhwinder Singh Sohal 🫁 @Romy_Sohal]

Sharing some insights in the @ATSBlueEditor from our recent work on vascular / arterial pruning in smokers, and patients with early COPD. Similar pathology was evident in asthma-COPD overlap patients. EndMT seems central to destructive vascular pathology.
https://t.co/azS9Cf6kF8

[Sukhwinder Singh Sohal 🫁 @Romy_Sohal]

Pleased to share our Special Report discussing Pathophysiology of small airways in idiopathic pulmonary fibrosis (IPF): the silent zone ⁦@Monica_w_LU⁩ ⁦@Sohal_LabRTRG⁩ #IPF #airways https://t.co/4KCU0e4Fn7

[University of Tasmania @UTAS_]

Congrats to our own Dr Sukhwinder Sohal @Romy_Sohal who was recognised at the recent European Respiratory Society Congress for his extensive research work into lung health. Dr Sohal was joined by Dr Monica Lu @Monica_w_LU who presented three papers at the Congress 👏

[Portland Press @PPPublishing]

In this @Sohal_LabRTRG research article, Bhattarai et al. investigate the roles of drivers of endothelial to mesenchymal transition, uncovering an active endothelial SMAD pathway, independent of TGF-β1 in smokers, SAD, and COPD patients. #ClinSci #Smoking
https://t.co/7TnBZQuBis

[Sukhwinder Singh Sohal 🫁 @Romy_Sohal]

Nice to see our recent work making to cover of the Clinical Science! Very thankful to the Journal and Editors for recognizing the importance of this work in #COPD - https://t.co/vhLV1aOU1w

[Sukhwinder Singh Sohal 🫁 @Romy_Sohal]

Pleased to share our recent publication presenting @WHO #Tobacco Knowledge Summary on #COPD. It has been a great pleasure working with WHO team, colleagues from @EuroRespSoc , @atscommunity, @tsanz_thoracic , GOLD, @ginasthma, and @APSRapsr @Monica_w_LU https://t.co/UT8eHnZlPi

[Prem Bhattarai @bhprem03]

Thank you @Romy_Sohal and @Sohal_LabRTRG for your support and contribution to this significant finding.@Monica_w_LU @matsuji2013 @d

[Sukhwinder Singh Sohal 🫁 @Romy_Sohal]

Recent work from our research group reporting endothelial TGFβ1, pSMAD2/3, SAMD7 and β-catenin in pulmonary arteries from smokers and COPD informing EndMT. Endothelial SMAD pathway is independent of TGF-β1 in smokers and COPD. https://t.co/HuU1ScndM3 @bhprem03 @Monica_w_LU

[Sukhwinder Singh Sohal 🫁 @Romy_Sohal]

Recent work from our research group reporting endothelial TGFβ1, pSMAD2/3, SAMD7 and β-catenin in pulmonary arteries from smokers and COPD informing EndMT. Endothelial SMAD pathway is independent of TGF-β1 in smokers and COPD. https://t.co/HuU1ScndM3 @bhprem03 @Monica_w_LU

[Prem Bhattarai @bhprem03]

Thanks to you @Romy_Sohal and the entire team @Sohal_LabRTRG @Monica_w_LU @matsuji2013 for your guidance and support throughout my PhD journey🙏 . Cheers🎉

[Sukhwinder Singh Sohal 🫁 @Romy_Sohal]

Many congratulations and well done to our PhD student @bhprem03, who is now Dr Bhattarai 😊. Prems research reported the novel process of EndMT and its contribution to pulmonary arterial remodelling in smokers, patients with small airway disease and early COPD @Monica_w_LU

[Sukhwinder Singh Sohal 🫁 @Romy_Sohal]

Large airway wall lamina propria in patients with asthma–COPD overlap is hypovascular with an increase in reticular basement membrane neoangiogenesis, reflecting smoking-related COPD-like pathology and potential epithelial-to-mesenchymal transition https://t.co/t43MeXP6c0 @deys79

[Prem Bhattarai @bhprem03]

Many congratulations Romy👏

[Sukhwinder Singh Sohal 🫁 @Romy_Sohal]

Very thankful to all involved in the journey 🙏
https://t.co/gqRfQeNBsI

[Prem Bhattarai @bhprem03]

It is an exciting news for all interested in slowing or arresting pre-COPD changes

[Shyamali C Dharmage @CDharmage]

This is such an exciting project. Hope we can find ways to arrest or slow the progression pre-COPD to #COPD @meilan_han

[Sukhwinder Singh Sohal 🫁 @Romy_Sohal]

Delighted to see our recent work on differential expression of mast cells in smokers, patients with small #airway disease and early #COPD highlighted on ERJ Open’s front page. Thanks very much @ERSpublications https://t.co/CBzsPrFe0a @matsuji2013 @Monica_w_LU @Sohal_LabRTRG

[Sukhwinder Singh Sohal 🫁 @Romy_Sohal]

Do not agree with EMT in asthma, no human tissue evidence, in fact negative with no core tissue structural Rbm fragmentation as key to EMT. Evidence is more in vitro in asthma (produced). EMT is central to COPD as evident from empiric human tissue work & further confirmed 😊

[Prem Bhattarai @bhprem03]

@Romy_Sohal @AffanShahzad7 @Monica_w_LU @JCM_MDPI @VediaZhang @matsuji2013 @deys79 @Archana_AUS Congratulations @AffanShahzad7 👏

[Prem Bhattarai @bhprem03]

Many Congratulations Romy👏well deserved !!

[Sukhwinder Singh Sohal 🫁 @Romy_Sohal]

Truely honoured to have become a Fellow of the @tsanz_thoracic The Fellow status is a mark of distinction, conferring recognition on members for their outstanding contributions to the Society as well as to the fields of pulmonary, critical care, and sleep medicine #tsanzasm2024

[Sukhwinder Singh Sohal 🫁 @Romy_Sohal]

Airway wall lamina propria in patients with Asthma-COPD Overlap (ACO) is hypo-vascular with increase in reticular basement membrane neo-angiogenesis, reflecting smoking-related COPD like pathology and EMT. https://t.co/9dS2nfUTIU

[Sukhwinder Singh Sohal 🫁 @Romy_Sohal]

Mast cells in smokers and patients with small airway disease and COPD may be associated with airway wall changes and impaired lung function, indicating an active role in maintaining normal tissue homeostasis and, indirectly, in airway architecture https://t.co/mJAyCSPHCT

[Prem Bhattarai @bhprem03]

Pleased to share our work and many congratulations @Archana_AUS @Romy_Sohal and RTRG team.

[Sukhwinder Singh Sohal 🫁 @Romy_Sohal]

Pleased to share recent work from our research group reporting TGF-β1, pSmad-2/3, Smad-7, and β-Catenin signalling pathways in the pulmonary arteries from patients IPF and their potential role in driving EndMT.
Link to paper - https://t.co/cdnUiaIfsh