Tim Blower

Senior Principal Investigator at New England Biolabs and Honorary Professor at Durham University. Views my own. He/him.

[Tim Blower @BlowerLab]

Postdoc position now open in my lab at New England Biolabs. Focus is on exploring phage defence systems through biochem and structural biology. @NEBiolabs provides an academic research environment with the freedom of industry. Please take a look! 🤓🧫🧬 https://t.co/sf9mizGumG

[New England Biolabs @NEBiolabs]

NEB researchers systematically screened 186 MazF homologs, identifying >130 active endoribonuclease with diverse sequence preferences. Read more about how Tth-MazF1 can be a powerful tool for RNA analysis in Nucleic Acids Research: https://t.co/ldz4rELeF1

[The Lister Institute of Preventive Medicine @ListerInstitute]

Rejection is part of science. So is resilience. 🔬

@BlowerLab and @CJStewart7 share how setbacks helped shape their careers. We don't talk about this enough.

🔁Please repost and share your own stories of defeat or bouceback. Break the stigma!

https://t.co/iWFzWm1mmn

[Tim Blower @BlowerLab]

Rel/Par superfamily toxins have yet another activity - trimming off the 16S rRNA to kill tuberculosis. Thanks again to wonderful collab with @GenevauxPierre and team, out today https://t.co/3pZD8ogyHB @DurBiol @NEBiolabs @izaakbeck 🤓🎊🎉

[Tim Blower @BlowerLab]

Looking for great PhD candidates! Excited to collab with Prof Mark Szczelkun at Bristol UK, studying MADS phage defence. This will be a CASE studentship including research visits to New England Biolabs HQ in MA, USA 🤓 @NEBiolabs https://t.co/eL214D9q36 deadline 3rd Dec

[Tim Blower @BlowerLab]

RptR is a new addition to the growing collection of phage defence-associated transcriptional regulators. Congrats to @YugengZ @TangLabOxford @_MarionSchuller @IvanAhelLab and thank you, it was a pleasure to help out the study! @NEBiolabs. https://t.co/tmVlGPmWEU

[Tim Blower @BlowerLab]

@joeBondyDenomy @DarrenSmithdx @NAR_Open @NEBiolabs @DurBiol Yup great question - working on it!

[Tim Blower @BlowerLab]

Latest BREX story from the lab - turns out there is a nuclease after all! Congrats to Jenny Readshaw and the whole team, including wonderful collabs Barry Stoddard, Brett Kaiser and @DarrenSmithdx. @NAR_Open @NEBiolabs @DurBiol https://t.co/AsZjImMSXW

[Antonia Sagona @antonia_sagona]

We are delighted to host Professor Tim Blower @BlowerLab as keynote speaker to our MID symposium
@WarwickLifeSci
Date: 20th of June Venue: GLT1 We invite MBio, PhD students and Postdocs to submit abstracts for posters and talks by 11th of June to
@CRodriguesLab

[Giuseppina Mariano @GiusyM1990]

For those of you who approached me at @MicrobioSoc #Microbio25 (and anyone else interested!!), this is your last chance to apply for our PDRA position. Come join us in Glasgow!

[Tim Blower @BlowerLab]

The post will be based in Ipswich, MA, north of Boston. Non-US citizens welcome (if eligible for a J-1 visa). The focus will be on basic research leading to publications. We provide an academic research and training environment, with >20 research labs.

[Tim Blower @BlowerLab]

The lab is now up and running at New England Biolabs @NEBiolabs! I'm looking for a postdoc to study phage defence systems. If you'd like the academic freedom to publish but the resources of industry, then take a look 🤓😃 https://t.co/v5V3STDowa

[Tim Blower @BlowerLab]

Super opportunity to join Giusy in Glasgow!

[Giuseppina Mariano @GiusyM1990]

🚨We are hiring! A MRC-funded PDRA position to study novel anti-phage systems & their evolutionary dynamics in P. aeruginosa, in collaboration with @friendlymicrobe. If you are passionate about phage-bacteria interactions & evolution, apply now ! https://t.co/o3sGEGBvrU

[Giuseppina Mariano @GiusyM1990]

The final version of our Serratia paper is now out! Congrats to @TomCX99 and (X-less) Suraj, and a big thank you to @BlowerLab and @StephenRG97. https://t.co/7PLGdTwYwT

[Giuseppina Mariano @GiusyM1990]

Over the moon to share some amazing news—I’ve been awarded an MRC Career Development Award to pursue my research at the University of Glasgow @UofGSii ! 🎉 Can’t wait to get started on this exciting new chapter. Stay tuned—I’ll soon be advertising a PDRA position!

[Dmitry Ghilarov @dghilarov]

Using cryoEM we understood the structural basis of chiral DNA wrap by bacterial gyrase (and also produced the most complete/highest resolution E coli gyrase model to date).

@JohnInnesCentre @DurhamU34989 @MCB_UJ

[xibing @xibing4]

Thrilled to share my latest postdoc paper published in
@NatureComms
NTase toxin targeting serine tRNA 3'-ends by CMP addition in M. tuberculosis H37Rv. Thanks to all the co-authors,
@GenevauxPierre
@BlowerLab
@ONeyrolles
https://t.co/PQ8ILs1qzM

[Rafa Pinilla-Redondo @rafapinilla92]

When experiments don’t work... build a phage costume! 🎃

Happy PHAGEOWEEN!!! 👻🧬#Teamwork

[Cryptic Prophage (phage 🧬🪤 in 🦠) @crypticprophage]

https://t.co/Pjgy5KTUrK
Our thoughts on how toxins bound to TAs are activated: via conformation changes, not by selective degradation of ATs by a protease (makes little sense since both are structured). Remarkable insights determined by studying various TAs as they inhibit phage.

[Tim Blower @BlowerLab]

@crypticprophage Fab - a super minireview! Thanks for including our study