Bob Frasure

A healthcare tech dude leveraging cloud, AI, & mobile. Head of o7AI, Mixagraph AI social network and others. Previous video game industry dev & evangelist.

[Bob Frasure @bobfrasure]

@11975MHz @Shadoff_d Seems like it was yesterday. Things move fast.

[Bob Frasure @bobfrasure]

@Shadoff_d @Paranoia_Dragon The Kisado was so popular in its time. I only held one but never owned one because they were continually sold out.

[Bob Frasure @bobfrasure]

@Shadoff_d David, I've been thinking the same thing for years. I see people getting rid of their real hardware for FPGAs thinking they are the answer, however what they don't realize is developers like me can't use them as the golden standard because they are ever so slightly different.

[David Sinclair @davidasinclair]

Key players:

Life Biosciences: first human dosing of a partial reprogramming therapy, targeting ophthalmology first

BioAge Labs: IPO plus two Big Pharma collaborations validating its aging-biology data platform

NewLimit: fastest capital velocity in epigenetic reprogramming, still pre-clinical

Retro Biosciences: best-funded of the private reprogramming players, with a clearer path in autophagy than in reprogramming

Altos Labs: launched in 2022 with the largest single commitment in the sector’s history ($3B), still without a disclosed clinical program

Insilico Medicine: the AI-native, Asia-anchored platform play, positioning discovery speed as its edge

https://t.co/ZuDpgoY0yR

[David Sinclair @davidasinclair]

Could light be an adjunct therapy for cancer?🚦

Shining red or green light on stem cells & T cells stimulates a protein called OPN4, normally found in the eye, and causes them to secrete factors that slow the growth of breast cancer cells 🧵

[Bob Frasure @bobfrasure]

@BitcoinBuki @Paranoia_Dragon @Shadoff_d Great work! This opens up very exciting possibilities

[Bob Frasure @bobfrasure]

@Shadoff_d @BitcoinBuki Dave, you’ve been making a difference in this community since before I even started in the mid 90s.

[Bob Frasure @bobfrasure]

@Kupiperx @yoshinokentarou The sound chip was fine for the time but was rarely pushed to its limits.

[Bob Frasure @bobfrasure]

@JackBox 33 minutes for an order tonight at 1105 S Val Vista Dr
Mesa, AZ
Guys what is going on. No customer service at all

[David Sinclair @davidasinclair]

For 25 years, my team has been told we were wrong, by scientists, big pharma, the media, ethicists, and trolls. It hasn’t been easy

Looking back, it was 100% worth it

Here’s why you should believe in yourself… 🧵

[Bob Frasure @bobfrasure]

@officer_Lew The wealthy do this too.

[David Sinclair @davidasinclair]

The use of bacterially produced enzymes to make NMN cheaply is the reason our lab finds endotoxin in some NMN batches. Endotoxin causes systemic inflammation.

Consumers and scientists, beware.

https://t.co/rXrt2nkOIQ

[Karl Mehta @karlmehta]

In the 1990s, a Harvard scientist made a wild claim:

"Aging is the loss of epigenetic information — and we can restore it."

The entire field dismissed him.

30 years later, the FDA just approved his gene therapy for the first human trial.

Here's why this changes everything: 🧵

[David Sinclair @davidasinclair]

NEW PAPER in Cell: Scientists have reprogrammed allergy (mast) cells to carry cancer-killing viruses straight to tumors, which if it works in humans could lead to more precise, personalized cancer treatments with fewer side effects

[Vinod Khosla @vkhosla]

A new breakthru in anti-aging research every month. Exciting

[David Sinclair @davidasinclair]

In anticipation of the first epigenetic age reversal drug candidate ER-100 going into humans, here is our latest collab review:

"Oculomics and AI: The eye as a biomarker for health span" https://t.co/nO9ONjOX5a

[vittorio @IterIntellectus]

we’re less than 10 years from decoding all animal communication and BCIs that let us talk back

an entire kingdom of minds we’ve been ignoring for 300,000 years
going to be really fun

[David Sinclair @davidasinclair]

The most frustrating sentence in medicine is:
That’s just normal for your age

[FoundMyFitness Clips @fmfclips]

Two years of structured, vigorous exercise reversed about 20 years of age-related structural changes in the hearts of sedentary 50-year-olds

Under Dr. Ben Levine’s protocol, participants gradually built up to 5–6 hours/week of training, including Norwegian 4x4 intervals, endurance sessions, and strength work

By the end, the size and stiffness of their hearts resembled those of a typical 30-year-old

Vigorous exercise is powerful medicine

[David Sinclair @davidasinclair]

Fingers crossed for the world's first epigenetic reprogramming human trial @lifebiosciences to be successful🤞https://t.co/X2B6pPgV8I