Nicolai Stransky

Pharmacist, MD/PhD student, EBM

[Nicolai Stransky @bodewitska]

@JSheltzer @ScienceMagazine Great to see an old hypothesis being put to the test in such an elegant way. Congratulation to everyone involved!

What happens to mdm4 Protein levels after removal of the triploid 1q?

[Nicolai Stransky @bodewitska]

@drjohnm Well taken, I guess my original thought was about other off-targets / nonspecific effects.

[Nicolai Stransky @bodewitska]

@drjohnm again: I don't think this to be likely, I was just wondering if slightly more careful wording would be more appropriate

[Nicolai Stransky @bodewitska]

@drjohnm I agree 100% with your analysis.

Just one thought about the wording: Do we actually "know" it can only reduce stroke and bleeding? What about microemboli to the kidneys, spleen, ... which could - theoretically - also translate to a mortality benefit

[Nicolai Stransky @bodewitska]

@ErnMedBlog Wir ist Ihre Einschätzung der Studie im Hinblick auf Vibration of Effects? Insbesondere da die Studie nicht präregistriert wurde (laut Prospero am 31.12.2022...), frage ich mich wie stark die Ergebnisse durch analytische Flexibilität beeinflusst worden sein könnten?

[Nicolai Stransky @bodewitska]

@Chr_Schoeps Pre-Test Probability für erfolgreiche Translation ist leider sehr gering (<5%?)
"Even the most promising findings of basic research take a long time to translate into clinical experimentation, and adoption in clinical practice is rare"
https://t.co/Tfb1YUvUyA

[Nicolai Stransky @bodewitska]

@DrChristianWin1 Also zumindest in den Ländern deren Debatten ich folgen kann (USA und UK) läuft die Polarisierung in beide Richtungen leider sehr sehr ähnlich

[Alasdair Munro @apsmunro]

I’d estimate at least 99.9% of all the twitter takes I’ve read about RCTs on mask use or this new Cochrane review are abysmally wrong

“We don’t need RCTs we have physics”

And

“See, proof masks do NOTHING”

Will generate lots of likes and RT and are both excruciatingly false

[Nicolai Stransky @bodewitska]

@VPrasadMDMPH Also kind of frustrating to discuss plans for surgery with someone not being the actual surgeon in the end for an elective procedure ... is this also commonplace in the US?

[Nicolai Stransky @bodewitska]

@bttyeo wait - are you telling me it is not possible to rewrite the same methodology 10x in a logicial and coherent way? :)

[Nicolai Stransky @bodewitska]

@whereisdaz @DrAseemMalhotra @jordanbpeterson Imagine having the confidence attaching your name to this. wtf

[Nicolai Stransky @bodewitska]

@drjohnm @VPrasadMDMPH @TheFP @EmilyYoffe @bariweiss Well balanced and a pleasure to read; kudos to the authors :)

[Nicolai Stransky @bodewitska]

@Januschka3 @JvA68518443 @Schleh_Tox Die Pharmalobby schon wieder

[Nicolai Stransky @bodewitska]

@AndrewFoy82 @MRuzieh I see. Nevertheless, I think this triangulating approach is really useful to test ones hypothesis in observational research! So kudos to you!

[Nicolai Stransky @bodewitska]

@DanielWefers @UniHalle Super Artikel! 100% treffend für eine pragmatische Herangehensweise zu appellieren! Pseudoreligiöses Ablehnen alles 'Unnatürliches' erzeugt imho keine Compliance (was auch immer das überhaupt sein soll...).

[Nicolai Stransky @bodewitska]

@VPrasadMDMPH Convince them soon enough to avoid having to pay a lot of money to them :)

[Nicolai Stransky @bodewitska]

@TimoRoettger Clear and concise explanation of an much underappreciated skill. Have just shared this video with current ECRs in our lab and will do so with future ones!

[Nicolai Stransky @bodewitska]

Glad to have been a (small) part of this important work!

Reading recommendation for everyone planning to implement robust research practices in his/her own work!

[Dr Joanne Kenney @DrJoanneKenney]

🚨New publication🚨

Open, reproducible, replicable research is crucial for science.

Follow our 10 simple steps to implement robust research practices in your research projects.

@PLOSCompBiol @T_Weissgerber @RR_Oxford @ChariteBerlin @ReproducibiliT

https://t.co/hJGb5fy75v

[Nicolai Stransky @bodewitska]

@NicoGagelmann @MPN_RF @MPN_Hub @CanadianMpn @doctorpemm @harrisoncn1 @nihardesai7 @Sthanu5 @rschneiderlab Great thread!