Great to see this summary of our recent paper! With support from @czbiohub and @Stanford_ChEMH, we developed a new method enabling LC/MS-MS analysis of the urinary peptidome and used it to understand how gluten proteins are digested in patients with #celiac disease
New research from Biohub and @Stanford offers a new window into #celiac disease and human digestion, shows promise for testing and drug development:
https://t.co/JOsnnaCcuX
@ChrisNardone95 Of course! I learned a lot from you too. I’m sure I’ll still be around Boston every once in a while, and look forward to staying in touch!
Congrats, @ChrisNardone95 for this awesome work and for allowing me to play a small part in it. Can't wait to see all of the awesome science you do in the future!!
Thrilled to share my first paper from grad school out today in Mol Cell! I am incredibly grateful to the Elledge lab and my wonderful collaborators/friends, without them this work would not have been possible. https://t.co/SlAoxtlfxP
Institute Scholar Peter Kim @StanfordBiochem, first author and CBI grad student @p_weidenbacher & team found a way to imbue immune molecules once thought useless with the ability to put #SARSCoV2 in a therapeutic headlock it can't wriggle out of: https://t.co/NblFdBFtvg
So thankful to see that our paper leveraging non-neutralizing antibodies into broad-spectrum inhibitors for SARS-CoV-2 is now online in @nchembio! It has some fun updates, including that these ReconnAbs neutralize BA.2 and live virus!
https://t.co/qNph9FqzPr
Does anyone on #teammassspec have a protocol for Tryp-N digestions on S-Trap? The instructions say to include detergent (Rapigest). To me this doesn't seem necessary if already denatured on S-Trap. Would prefer not have to optimize over the weekend... @ProtifiLlc any advice?
Congrats on this beautiful work, @MackinawtheFish! As someone with HCM in my family, it feels so reassuring that we are better understanding the molecular underpinnings of this disease.
One-size-fits-all just doesn’t work for HCM mutations even when one focuses on a single functional subdomain of myosin- like the lever arm- in this beautiful work by @MackinawtheFish @debanjan_raja and others from Spudich Lab @eLife@StanfordBiochem
https://t.co/sNW5JmZKnh
@YishaiLevin You would think so, but I had compared this for my datasets a long time ago and it didn't make much of a difference. Beware though, some search engines didn't seem do do well with peptidomic data at least in my hands...may be worth considering.
Grateful to have had the opportunity to present my work at my first ever Gordon and brought back with me this piece of fancy paper (and some $ they say)! Learned about so much great science and made so many new friends! #BioorganicGRC
@catzcosta For peptides and metabolites, usually matters very little IME. Can make a big difference for intact or top-down protein work where averaging is often needed for sufficient S/N to resolve the isotopic envelope and assign charge states.