Brad Palanski

Postdoc @harvardmed @BrighamResearch @DanaFarber chemical rescue, proteomics, kinase signaling. | PhD @Stanford chemical biology and celiac disease. | ☕️ 🍷 🎾

[Brad Palanski @bpalanski]

Great to see this summary of our recent paper! With support from @czbiohub and @Stanford_ChEMH, we developed a new method enabling LC/MS-MS analysis of the urinary peptidome and used it to understand how gluten proteins are digested in patients with #celiac disease

[Chan Zuckerberg Biohub Network @czbiohub]

New research from Biohub and @Stanford offers a new window into #celiac disease and human digestion, shows promise for testing and drug development:

https://t.co/JOsnnaCcuX

[Brad Palanski @bpalanski]

@ChrisNardone95 Of course! I learned a lot from you too. I’m sure I’ll still be around Boston every once in a while, and look forward to staying in touch!

[Brad Palanski @bpalanski]

Congrats, @ChrisNardone95 for this awesome work and for allowing me to play a small part in it. Can't wait to see all of the awesome science you do in the future!!

[Chris Nardone @ChrisNardone95]

Thrilled to share my first paper from grad school out today in Mol Cell! I am incredibly grateful to the Elledge lab and my wonderful collaborators/friends, without them this work would not have been possible. https://t.co/SlAoxtlfxP

[Sarafan ChEM-H @Stanford_ChEMH]

Institute Scholar Peter Kim @StanfordBiochem, first author and CBI grad student @p_weidenbacher & team found a way to imbue immune molecules once thought useless with the ability to put #SARSCoV2 in a therapeutic headlock it can't wriggle out of: https://t.co/NblFdBFtvg

[Brad Palanski @bpalanski]

@chorye @stshuken 🙄

[Brad Palanski @bpalanski]

Magic to transform non-neutralizing antibodies into neutralizing! Congrats, Payton and team!

[Payton Weidenbacher, Ph.D. @p_weidenbacher]

So thankful to see that our paper leveraging non-neutralizing antibodies into broad-spectrum inhibitors for SARS-CoV-2 is now online in @nchembio! It has some fun updates, including that these ReconnAbs neutralize BA.2 and live virus!

https://t.co/qNph9FqzPr

[Brad Palanski @bpalanski]

@stshuken @mcs_phd Last time I had an El Grullense burrito I had food poisoning for 3 days. It was delicious tho...

[Brad Palanski @bpalanski]

@ProtifiLlc Awesome, thanks! As sample and time allow I’ll test both and report back!

[Brad Palanski @bpalanski]

Does anyone on #teammassspec have a protocol for Tryp-N digestions on S-Trap? The instructions say to include detergent (Rapigest). To me this doesn't seem necessary if already denatured on S-Trap. Would prefer not have to optimize over the weekend... @ProtifiLlc any advice?

[Brad Palanski @bpalanski]

@mcs_phd I have one!

[Brad Palanski @bpalanski]

@mcs_phd Maybe @CDCDirector could put a little more effort into a mask mandate so people can travel more safely

[Brad Palanski @bpalanski]

@mcs_phd I have never heard more people coughing than I did at Dulles on Thurs.

[Brad Palanski @bpalanski]

@mcs_phd It is on time 😭

[Brad Palanski @bpalanski]

@mcs_phd Cancelled my connecting flight and omw

[Brad Palanski @bpalanski]

Congrats on this beautiful work, @MackinawtheFish! As someone with HCM in my family, it feels so reassuring that we are better understanding the molecular underpinnings of this disease.

[Neha Nandwani @NehaNandwani5]

One-size-fits-all just doesn’t work for HCM mutations even when one focuses on a single functional subdomain of myosin- like the lever arm- in this beautiful work by @MackinawtheFish @debanjan_raja and others from Spudich Lab @eLife @StanfordBiochem

https://t.co/sNW5JmZKnh

[Brad Palanski @bpalanski]

@YishaiLevin

[Brad Palanski @bpalanski]

@YishaiLevin You would think so, but I had compared this for my datasets a long time ago and it didn't make much of a difference. Beware though, some search engines didn't seem do do well with peptidomic data at least in my hands...may be worth considering.

[Brad Palanski @bpalanski]

@mcs_phd 😒

[Brad Palanski @bpalanski]

Congrats to my labmate for this recognition of the awesome work she’s doing toward her PhD!

[Maggie Chen @maggiechenchen]

Grateful to have had the opportunity to present my work at my first ever Gordon and brought back with me this piece of fancy paper (and some $ they say)! Learned about so much great science and made so many new friends! #BioorganicGRC

[Brad Palanski @bpalanski]

@Bob_Wachter @threadreaderapp unroll

[Brad Palanski @bpalanski]

@catzcosta For peptides and metabolites, usually matters very little IME. Can make a big difference for intact or top-down protein work where averaging is often needed for sufficient S/N to resolve the isotopic envelope and assign charge states.