Brent Tan

Associate Professor, Stanford Hematopathology #hemepath

[CU Hemepath @CUHemepath]

The cytoplasmic vacuoles raises a ddx of VEXAS, MDS, copper deficiency, and other drug/toxicity related changes. The patient had undetectable levels of copper, and her counts normalized after supplementation. This was a case of copper deficiency associated anemia.

[Anas Nasir @BloodScientist]

#MorphologyMonday

This peripheral blood film had been sitting in one my boxes and having taken these pictures, I thought it would be a good one to share. What do you think?

#underthescope #biomedicalscientist #haematology

[Nicholas Ward, MD @NicholasWardMD]

Best case of Kikuchi-Fujimoto I have seen! All three phases: proliferative, necrotizing and xanthomatous. Negative auto-immune panel (no SLE). Why are histiocytes MPO(+)in KFD?
Plasticity? Functional versatility? Unique/myeloid dendritic cell?

[Dennis P. O'Malley, MD @DennisOMalleyMD]

#hemepath Gaucher dz in bone marrow

[Mark Ong @DrMarkOng]

Young adult with intra-abdominal mass. Bone marrow trephine biopsy. Starry sky appearance of Burkitt's lymphoma #hemepath

[Mark Ong @DrMarkOng]

Adult female. Duodenal biopsies.

What do you think is going on? What would you do next?

#GIpath

[Lauren Smith, MD, HEC-C @lbsmithmd]

Young person (30s) with mediastinal mass. Impending SVC syndrome. What’s your differential and most likely dx? #hemepath #pathology What immunostains?

[Mark Ong @DrMarkOng]

Elderly male with testicular mass. #IHC and diagnosis in next tweet.

[Mark Ong @DrMarkOng]

40M lymphadenopathy and B-symptoms.

I really wished I'd taken pictures of IHC at the time (no easy access to camera then), so you will have to trust me on the final diagnosis.

Any takers with just a H&E? #hemepath

[Sanam Loghavi, MD صنم لغوی 🔬🧬 @sanamloghavi]

The "kissing" nuclei of follicular dendritic cells.. this is what you read about in textbooks.

Note the delicate nuclear chromatin and small central nucleoli. #hemepath #HemepathMDA

[Chandra Krishnan, MD @hematogones]

I've never had a chance to make this diagnosis until today.

Dx: Adrenal myelolipoma

One more thing off of my #pathologybucketlist

[Brent Tan @brent_tan]

@ariella8 Follicular lymphoma, grade 3a. It is hard to tell from the pics whether there is also dlbcl

[Sara Javidiparsijani, MD, FCAP @javidiparsijani]

Intravascular Large B cell Lymphoma: large CD20(+) CD5(weak +) lymphoma cells are confined to CD34(+) sinusoids in the marrow #rarelymphoma

[Michael Cascio, MD @mjcascio]

Example of Kikuchi-Fujimoto disease. We were lucky enough to do a scrape prep to see some of those crescentic histiocytes. MPO in this case was more robust than usual. #hemepath #pathology

[Sara Javidiparsijani, MD, FCAP @javidiparsijani]

Myeloid leukemia associated with Down syndrome. The blasts have megakaryoblastic morphology and immunophenotype, including cytoplasmic buddings "blebs" and positivity for CD56, CD36, CD42b, CD11b, CD61(this one is dim), CD4(partial +) and CD34(-)

[Daniel Babu, MD @DanBabuMD]

It's well-known that B-lymphoblastic leukemia can rarely have granules, but I've never seen one so intensely granular as this! MPO negative with straightforward precursor B-cell phenotype by flow. Young adult patient. #hemepath

[Kyle Bradley, MD @KyleBradleyMD]

Toxoplasma cysts are extremely rare!

(Probably <1% of toxoplasma cases.)

[Ellen Yeh @Yeh_Lab]

Please check this website for up-to-date requests for #BayArea donations for #Stanford #COVID19 testing: https://t.co/xF4bHUiNCs
in retrospect this seems obvious but alas hindsight is 20/20

[Judith Ferry @judith_ferry]

Testing of the lesion by NGS showed mutations of NOTCH1. NOTCH1 is mutated in about 60% of cases of T-ALL/LBL.

[Chandra Krishnan, MD @hematogones]

What's your diagnosis of this EBV+ B-cell lymphoma?

Adult female, HIV+ with adenopathy. Poor compliance on HAART.

WSI + IHCs: https://t.co/XeFtkTnRYX

#hemepath