Jon Brestoff

Associate Professor MD/PhD @WashuMedicine studying #immunometabolism and #mitochondria transfer in metabolic diseases like #obesity #diabetes and #LeighSyndrome

[Jon Brestoff @BrestoffLab]

Curious about #mitochondria transfer?

Check out our latest #MitoTransfer review with the @theHumanBorch in @Nature

Feel free to post your thoughts, ideas, and questions below. Please RT to help grow this blossoming field.

https://t.co/8sRQlKPpR9

[Jon Brestoff @BrestoffLab]

@CaicedoLab Wow! Congrats Andres!

[Mike Lustgarten, PhD @mike_lustgarten]

Butyrate extends health and lifespan in mice with mitochondrial deficiency

https://t.co/5vJ3r12Ex0

[Delgoffe Lab @DelgoffeLab]

Dearest gentle reader, we are delighted to announce a new story from our lab published in @Nature describing how a meal's systemic metabolic changes are interpreted by your immune system to enhance adaptive immunity. A thread 1/ https://t.co/zACqCLxDMU

[Jon Brestoff @BrestoffLab]

@v_moreno_juan @Samanthakrysa @Nature Great work! Congrats on your exciting and important paper!

[Jon Brestoff @BrestoffLab]

Exciting new paper on #MitoCatch to target mitochondria transplants to cells of interest, rescuing neurons in #LHON

Check out our News & Views in @Nature for a synopsis and big questions for the field:

https://t.co/04xZKWkdXb

@washu_pathology @washumedicine @Samanthakrysa

[Jon Brestoff @BrestoffLab]

@NatRevImmunol @rockygiwa

[Zane Koch @zanehkoch]

ok actually insane paper published yesterday

a research group in Korea built a gene switch you can control wirelessly using electromagnetic fields

they exposed mice to 60 hz EMF (same frequency as your wall outlet) using a pair of large coils that generate a uniform magnetic field around the animal, for cyclic 3-day on / 4-day off pulses

they showed this could:
- activate OSK to do epigenetic reprogramming in progeroid and aged mice, extending lifespan and reversing aging markers across multiple tissues
- conditionally switch on mutant amyloid genes only in aged mouse brains, letting them separate aging effects from amyloid effects to study AD biology in a way previous models couldn't

no drugs, no impacts, just a magnetic field from outside the body

[Jon Brestoff @BrestoffLab]

@v_moreno_juan @NicolasAvilaJA @Nature @IOB_ch Congrats! Exciting paper!

[Kika @v_moreno_juan]

I am very happy to share that our paper is now published in @Nature 😊
Cell-type-targeted mitochondrial transplantation rescues cell degeneration.
https://t.co/lQACEJLDwg
@IOB_ch (1/6)

[Nirosha J. Murugan @niroshajmurugan]

Coming up in this research space, reviewers and peers made it very clear that any non-visual effects of light on biology were not to be discussed in the public forum.

What an exciting development to see the effects of energetic patterns rooted within the electromagnetic spectrum featured in @Nature .

Looking forward to the flood of exciting research programs and therapeutics to emerge in the next few years.

The bittersweet reality is that the effects existed before this high-profile exposure. But better late than never!

[Jon Brestoff @BrestoffLab]

@niroshajmurugan @TOEwithCurt I love this

[Martin Picard @MitoPsychoBio]

I’m excited to be launching a new publication on Substack today: The Science and Experience of Energy!

The last few years have invited me, like many of us, to clarify my place in the world. I’m a scientist who’s devoted his career to bridging mitochondrial science and psychobiology. But I want to do more than just publishing papers for other academics—it’s important, but not sufficient.

I am moved to bridge science and experience not just in the lab, but in life as well.

That’s why I’m writing the ENERGY book. And why starting this Substack makes sense now. It feels like a coming out of sort, from my academic shell: sharing some things that non-scientists may not know about, and sharing experiences that scientists typically don’t talk about.

That bridging of science and experience, I feel, will propel us forward towards a deeper truth about who we are and how we can fulfill our potential.

I’m excited to share this journey with you.

In this publication, you’ll find three types of pieces:
1. The ENERGY SCIENCE pieces will share the latest advances in mitochondrial science.

2. The BEHIND THE PAPER category will describe how a specific study came to be, or the backstory of a discovery.

3. The LIVED EXPERIENCES will allow you to connect with other human beings willing to share their energetic experience of growth and transformation.

Everything in this publication will always be free.

I’ll put energy in each post. And as the publication grows, we’ll invite others to contribute their energy as well, including my wonderful wife @msahsorin.

Please join us by subscribing. And if you feel so compelled, sharing with your community.

https://t.co/Vm3Q3ujJSe

[Nature Metabolism @NatMetabolism]

#throwback

COMMENT | @CreweLab et al

A brief guide to studying extracellular vesicle function in the context of metabolism

https://t.co/pzG9HzGNzc

[Jon Brestoff @BrestoffLab]

@GreletLab @NatMetabolism Thanks, Simon

[Jon Brestoff @BrestoffLab]

This was a fun surprise today! #1 cited review in @NatMetabolism in 2025.

[Nature Metabolism @NatMetabolism]

Reviews/Perspectives Top #Citations 2025: 🥇

Jonathan Brestoff (@BrestoffLab, @WashUDeptMed), Keshav Singh (@mitoscientist, @UABHeersink) et al.

Recommendations for mitochondria transfer and transplantation nomenclature and characterization

https://t.co/Sxu3fDDXJm

[Jon Brestoff @BrestoffLab]

Steven L Teitelbaum, MD, a legend @washumedicine, passed away.

He was a rigorous physician-scientist, life altering mentor, fierce advocate, and family man. I feel lucky to have gotten to work so closely with him. Few have taught me as much as he did.

[Jon Brestoff @BrestoffLab]

Proud to announce Dr Stella Varnum!

Her defense today was flawless. She is the first PhD student to graduate from my lab, so it was extra bittersweet today. #proudPI @WUSTLImmuno

[Jon Brestoff @BrestoffLab]

Very excited for tomorrow and for soon-to-be Dr. Stella Varnum!

[Jon Brestoff @BrestoffLab]

@MitoPsychoBio @riegalski Thanks Martin!

[Eric Topol @EricTopol]

Boosting mitochondria number and function to slow cellular aging
https://t.co/h9CqQ9f263
https://t.co/ZnbqwAwdQG