Justin Briggs

Scientist & Investor | Partner @PrimeMoversLab | Advisor @TulsaLocalVentures & @GKFF | Building the future | Ancora imparo.

[Justin Briggs @Briggsly]

Life at the Limit: The Economics of Cheating Death https://t.co/5fZZp2pWMb

[Blake Scholl 🛫 @bscholl]

Today Boom unveils our first completed supersonic turbine core, a 2GW Superfactory, and—one more thing—the world's most advanced all-digital foundry to cast single crystal turbine blades and vanes https://t.co/q2KpL3dZi2

[Prime Movers Lab @PrimeMoversLab]

Since 2022, Google, Meta and SoCal Edison have contracted ~1.2 GW of geothermal power from plants that haven’t been built yet, at $105–107/MWh.

AI needs firm, carbon-free power. Our new white paper looks at where geothermal goes next: https://t.co/MIL0fzsN9A

[Brett Adcock @adcock_brett]

The team blindsided me with a polygraph test, it was crazy. But it's important to me that Hark does this right.

Your data is yours.

[Justin Briggs @Briggsly]

@lefttailguy No, the rubber meets the road well before clinical trials. Those with poor IVIC will benefit from clinical/acc the rest will win with the right molecule.

[Prime Movers Lab @PrimeMoversLab]

"Okay, I have a lot to say."

Those were the first words a Michigan woman with motor neuron disease spoke through @Paradromics' Connexus BCI. @Forbes calls it a landmark year for the company and the implanted brain-computer interfaces. 🔗 https://t.co/UawYtRYdKU

[Justin Briggs @Briggsly]

@RPavuluri @bendingspoons @Roivant @BridgeBioPharma @formationbio This is the nondescript underbelly of biopharma. Incrementalism made manifest. Why would you want this?

[Justin Briggs @Briggsly]

@NatalieFratto @tunguz I think this tweet will age surprisingly well

[Packy McCormick @packyM]

The race for the most important results in science is a two-horse race between:

- LLMs backed by trillions of dollars, armies of geniuses, and the full weight of capitalism

and

- Michael Levin

My money is on Michael Levin.

[Prime Movers Lab @PrimeMoversLab]

Struldbrugg, Dorian Gray, Peter Pan, and Wolverine are all longevity-biology archetypes.

Only one unlocks the real trillion-dollar prize, and our reimbursement system rewards exactly the wrong one. Partner Justin Briggs (@briggsly) maps the longevity investment landscape and outlines the technology that excites us most.

Read his latest piece on Substack: https://t.co/3LGcrE1Jrs

[Justin Briggs @Briggsly]

$38 trillion is longevity’s most-quoted number, and the least useful.

It isn’t revenue, it isn’t annual, it isn’t addressable, and it’s not what your drug will earn.

It’s the societal value of one added healthy year.

New piece for @primemoverslab on what a year of life is actually worth. And why how you add it matters more than how big the headline is.
https://t.co/An1p7Lvbpn

[Justin Briggs @Briggsly]

@tunguz Used to do this with friends next to the lake. Absolutely doing this next 4th of July. Staging a large scale human v. drone Roman candle war would be EPIC.

[Justin Briggs @Briggsly]

@EricTopol Likely oxytocin/pitocin plus an indirect ALK5i/TGF-b blocker like losartan (OT+A5i). From her lab's 2025 Aging paper, right there in her CV. https://t.co/Cm9UNjiqsr

[Justin Briggs @Briggsly]

@Icannos @AnthropicAI This. Anthropic only showed Claude is an able verifier. They probably accelerated design verifiers, but Claude itself didn’t design a single sequence. See the prompts: https://t.co/EsFOgi00rM

[Justin Briggs @Briggsly]

This is marketing not science. Claude didn’t design a single one of these proteins. It read up on all the open source models, implemented them in the sandbox, and judged the results. Like building a kit car and calling yourself a car designer. Check the prompts yourself: https://t.co/S8qJPKgeNo

[Justin Briggs @Briggsly]

@BiochemPhD Don't we all! I want to run Kimi and Deepseek. ALMOST able to do the quantized DeepSeek, but it stalls once context gets anywhere near usable.

[Justin Briggs @Briggsly]

If you think local models still suck ... get qwen3.8-27b and be utterly impressed.

[Justin Briggs @Briggsly]

@BiochemPhD M5 128GB (with tons of headroom!) via LMStudio. Having it parse a 10k line CSV file line by line and research each row. Very impressed. Going to add it tonight to my old 64GB laptop running 24/7 and connected via Hermes gateway so I can run locally from anywhere. 🔥🚀