Bubs

TikTok/Instagram/YouTube: bubsonline

[Bryan Johnson @bryan_johnson]

I take Cialis, but not for sex.

It’s actually a longevity medicine.

Cialis (Tadalafil) is great for the same reason it gives you fantastic erections… it improves blood flow.

Studies show that Tadalafil…

+ 34% reduced all-cause mortality
+ 27% reduced major heart disease
+ 34% reduced stroke
+ 32% reduced dementia

It has also shown benefit in insulin sensitivity, metabolic health, and reduction of body fat.

Women have blood vessels too, so theoretically they'd get the same longevity upside. The research is thinner, but early signals are promising.

It’s sad that when men and women could benefit from it can miss out because it’s taboo.

My protocol is 5mg daily and I've been on it for about two years.

*Observational research shows associations, not causation. Outcomes may be influenced by underlying differences in study populations. This is not medical advice and is shared for informational purposes only.

[Gad Saad @GadSaad]

Oh no! This is Islamophobic forbidden knowledge.

[lady faustus @maskbeth]

Görmeden olmaz, merak edenler için tam olarak bu kastedilmiş. Gemini, sağ olsun ❤️
Ayakta deneyince hemen anlayacaksınız.
Önce yürürken dikkatinizi öne attığınız ayağa verin. Sanki kendinizi o ayakla ileri çekiyormuşsunuz gibi yürüyün.
Sonra aynı şeyi arkadaki ayağınızla deneyin. Bir süre fark ederek yürüyeceğiz sanırım. Otopilottan çıkmak için güzel bir egzersiz :)

[Brandon Luu, MD @BrandonLuuMD]

Being a blissfully unbothered optimist who brushes everything off predicts better health nearly a decade later.

Ripped apart by your boss? Thank them for the feedback and forget it by dinner.
Made a mistake? Useful data.
Bad day? What bad day?

[Joe Rogan Recaps @JoeRoganRecaps]

New: Joe Rogan leaves NASA astrophysicist Michelle Thaller completely stuck after asking her a deep question about the reality of time:

ROGAN: “The weirdest thing that I’ve ever heard anybody say is that all time exists currently.”

THALLER: “That’s Albert Einstein.”

ROGAN: “When we measure time what exactly are we measuring? When we create a clock that runs 24 hours per day what is it measuring?”

THALLER: “That’s a deep question. That question caused everything in physics to fall apart.”

ROGAN: “I still don’t understand what we’re measuring.”

THALLER: “I don’t think I have an answer for you. I don’t think anybody does.”

[Dr. Rhonda Patrick @foundmyfitness]

The sleep "sweet spot" for biological aging isn't 8 hours per night.

6.4-7.8 hours was associated with the lowest biological age gaps across 23 organ-specific clocks including the brain, liver, pancreas, skin, and adipose tissue.

Short (<6 hours) and long (>8 hours) sleep were both associated with higher biological aging, but likely for different reasons.

Short sleep may directly cause aging, while long sleep may reflect underlying disease or pathology - something that causes someone to require more sleep due to fatigue, recovery, or poor sleep quality.

[BowTiedPhys @BowTiedPhys]

5 minutes of a comedy clip before a creative problem-solving task ~3.5x'd the solve rate vs. a neutral clip (75% vs. 20%)

Non-slop levity unlocks latent ingenuity

[Bryan Johnson @bryan_johnson]

This is it.
Everything learned spending millions on longevity.

From: Your Immortal Unc and Auntie.
To: Our Immortal nieces and nephews.

0. Sleep is the world's most powerful drug.
1. Be in your bed for 8 hours
2. Same bedtime every night, any time before midnight
3. Don’t eat right before bed
4. Calm foods for dinner
5. No screens 1 hour before bed
6. Avoid added sugar (be aware it’s in everything)
7. Avoid all things in an American convenience store
8. Avoid fried foods
9. Shoes off at the door
10. Eat whole foods, particularly veggies fruits nuts legumes berries
11. Walk a little after meals or air squats
12. Get your heart rate high routinely
13. Lift heavy things
14. Stretch daily
15. Water pik, floss, brush, tongue scrape, morning and night
16. Make an effort to drink water
17. Get sunlight when you wake up (UV is low)
18. Protect skin in midday sun
19. Stand up straight
20. See at least one friend once a week
21. Avoid plastic where you can (in all things)
22. Circulate air in rooms
23. When stressed, breathe, learn to calm your body
24. Go to the dentist
25. Avoid sitting for long times
26. Protect your hearing, the world is too loud
27. Alcohol is bad for you
28. Finish coffee before noon
29. Avoid bright lights after sunset
30. If obese, look into a GLP
31. Sleep in a cold room
32. Texting while driving is dangerous
33. Turn off all notifications
34. Limit social media use
35. Don’t smoke anything
36. If you struggle to sleep, read a physical book before bed
37. 1 hour before bed have a calm wind down routine: bath, read, light walk, listen to music
38. The body is a clock and loves routine. Have a daily morning and evening schedule.
39. Avoid long distance travel where you can
40. Baby steps first: incorporate new things slowly
41. Do less… most things don’t work.

Bonus points if you get your blood checked.

Start here, it will change your life.

[Bubs @bubsonline]

@slingerland20 I’m currently reading Trying Not To Try and it’s brilliant. You explain Wu-Wei and De so well. I have a Taoism series on TikTok/Instagram (bubsonline) explaining how Taoism could integrate with bio haptic wearables to help guide one to the Tao through an AI learning pathway.

[Sean OMara MD, JD @DrSeanOMara]

At 24 hours of fasting, autophagy begins. At 36 hours, it triples. At 72 hours, it maxes out.

If you have never fasted past a single meal skip, your body has never run its own cleanup cycle. Not once. Not in years.

The heart fat, the visceral fat, the dead tissue — it is all still there because you never gave your body permission to burn it.

You need to fast, and you need to make it a habit.

[Nicholas Fabiano, MD @NTFabiano]

People with high IQ have faster and longer neurons.

[BowTiedPhys @BowTiedPhys]

Very few health levers keep reducing risk the more you do them.

Low-intensity, low-impact movement spread throughout the day is one of them.

Simple prescription: Walk more &amp; walk often.

[Aakash Gupta @aakashgupta]

20 minutes in a 174°F sauna, four times a week, drops all-cause mortality by 40%.

Jari Laukkanen tracked 2,315 Finnish men for 20 years. Compared to once-a-week users, the 4-7 sessions per week group had 50% lower fatal cardiovascular disease, 63% lower sudden cardiac death, and 65% lower Alzheimer's risk. Same cohort. Same age range. The variable was sauna frequency.

The mechanism is heat shock proteins, and a new 52-page review in Comprehensive Physiology just compiled the evidence.

When core body temperature rises 1-2°C, cells register the heat as proteotoxic stress. A transcription factor called HSF1 moves to the nucleus and switches on the genes for HSP70 and HSP90. These are molecular chaperones. They find proteins that have started to misfold, and either refold them or mark them for destruction.

The misfolding pathway HSP70 catches is the same one that causes Alzheimer's. Beta-amyloid and tau aggregate when protein quality control fails. HSP70 binds these proteins before they clump. The 65% Alzheimer's reduction in the Finnish cohort traces back to this single piece of biology.

HSP90 hits a different target. It stabilizes endothelial nitric oxide synthase, the enzyme that produces NO in blood vessel walls. NO tells arteries to dilate. Endothelial dysfunction shows up on imaging years before atherosclerosis is clinical. Heat upregulates HSP90, HSP90 keeps eNOS working, vessels keep dilating. The 50% cardiovascular mortality reduction lives here.

HSP70 also blocks JNK, the kinase that phosphorylates the insulin receptor substrate when you eat too much sugar for too long. This is the molecular reason heat therapy improves glycemic control in prediabetics without weight loss as the confound.

Different disease clusters. The upstream signaling is one protein folding response.

Heat is the cheapest way to trigger it. Exercise also works, but only if you can exercise. Hot water immersion works. Lower-leg heating works. The trigger is internal core temperature, not the modality.

Finland built sauna culture around warmth and community. The disease prevention was a side effect nobody had the molecular vocabulary for until 40 years later.

One stress response. Three of the top five killers. The trigger is a 174°F room you sit in for twenty minutes.

[Dr. Julie Gurner @drgurner]

Nick Saban's 5 Enemies of Greatness.
Tack them on a wall.

[Neoptolemus @NeoptolemusX]

It’s one thing to see a graph saying, “12 million illegal migrants entered Europe since 2008.”

It’s another thing to actually see it.

Every blip in this animation represents 100 people.

[Steve Stewart-Williams @SteveStuWill]

Smarter People Are Less Violent

"The prevalence of violent behavior dropped steadily with increasing IQ: 16.3% of individuals with IQs in the 70-79 range reported violent behavior, compared with just 2.9% of those with IQs of 120-129."

https://t.co/4XMLOE0add

[Gerry DeFilippo @Challenger_ST]

🚨 What if the secret to success isn’t talent or luck… but one simple daily choice?

Nick Saban drops truth: Every single day, you face the same 2 questions:

1. Something you KNOW you should do… but don’t FEEL like doing?

Can you make yourself do it anyway?

2. Something you know you shouldn’t do… but really WANT to?

Can you stop yourself?

Getting out of bed when the alarm hits

Hitting the gym when you’d rather scroll

Studying or grinding when Netflix calls

Choosing the hard right over the easy wrong

This is the invisible bridge between where you are… and who you want to become

Put your choices ahead of your feelings

Because if you only do what you feel like doing, you’ll never reach your goals

This one mindset shift changes everything for champions — and it can change everything for YOU too.

[Jake Gilman @jakeglmn]

Every morning, roughly 150 million Americans make a cup of coffee.

Most of them are drinking microplastics without knowing it.

A 2025 study published in Science of the Total Environment tested 155 hot and cold beverages across the UK market using contamination-free methods: glass, paper, and metal equipment only, so nothing in the lab could skew the results. Not a single beverage was free from microplastic contamination.

Here's what's actually happening inside your coffee maker every morning:

Paper cups are not made of paper alone. They're lined with polyethylene plastic, which is what makes them waterproof. When hot liquid hits that lining, the plastic degrades. Researchers found that a single paper cup releases approximately 25,000 micron-sized plastic particles into a hot beverage in just 15 minutes. Along with those particles come phthalates, heavy metals including lead and chromium, and endocrine disruptors (compounds that interfere with hormone signaling).

Your coffee machine is doing the same thing. Hot water passes through plastic components, plastic tubing, plastic reservoirs. Temperature is the dominant factor in microplastic release - the hotter the liquid, the more plastic sheds into it. Coffee is brewed at roughly 90°C. That is exactly the temperature at which plastic degradation accelerates most significantly.

Travel mugs compound the problem. Most are lined with plastic or have plastic seals. You brew hot coffee through a plastic machine, pour it into a plastic-lined cup, and drink it through a plastic lid.

This matters because of where microplastics end up. Researchers at the University of New Mexico recently found microplastics accumulating in human brain tissue at concentrations significantly higher than in other organs. Separate research identified microplastics in brain tissue from dementia patients. The connection between chronic microplastic exposure and neurological outcomes is still being studied but the accumulation in brain tissue is no longer theoretical.

Dr. Shanna Swan has spent her career documenting what endocrine-disrupting chemicals do to human reproductive and hormonal systems. Her research shows sperm counts have dropped more than 50% since the 1970s. Testosterone levels are declining across generations. The timing correlates directly with the explosion of plastic in the food and beverage supply.

The morning coffee ritual is not a minor exposure. For most people it is a daily event with multiple plastic surfaces. Repeated 365 times a year for decades.

The fix is straightforward and costs almost nothing relative to the risk.

A stainless steel kettle eliminates hot water contact with plastic entirely. A French press brews coffee without plastic components. A ceramic or stainless steel mug has no plastic lining.

Most people making changes to protect themselves from microplastics are focused on food packaging, bottled water, or plastic containers. Those matter. But they're ignoring the daily event where hot liquid passes directly through plastic at the exact temperature that maximizes chemical release, and they drink every drop of it.

Your morning coffee is the highest-leverage change you can make.

[BowTiedPhys @BowTiedPhys]

8 hrs of sleep was a psyop

[Nicholas Fabiano, MD @NTFabiano]

A walk in nature reduces rumination &amp; brain activity in an area linked to mental illness.

This effect was not seen with a walk in a city.