💦 Congestion in heart failure isn’t a snapshot — it’s a film.
That’s the question driving our research line for the past few years: how to assess congestion in ADHF more precisely than physical exam allows?
Stem-Cell–Derived Biologic Ventricular Assist Tissue in Heart Failure (#BioVAT-HF)
In advanced HF, cardiac remuscularization with #BioVAT was associated with an increase in the target heart wall thickness, #LVEF, and QoL in a small early-stage study.
#NEJM@NEJM
https://t.co/xPeoYsbyIs
🔴 OCEAN-Mitral Registry | n=1,638 patients after M-TEER for secondary MR
More GDMT after TEER = better survival. The dose-response is clear (p<0.001):
▪️ Quadruple GDMT → best outcomes
▪️ Triple > Double > Single GDMT
Predictors of GDMT increase post-M-TEER:
✅ Higher heart rate
✅ Worse NYHA class
❌ Previous CIEDs & moderate TR after TEER → less likely to uptitrate
💡 TEER isn’t the finish line — it’s the starting gun for GDMT optimization.
#HeartFailure26 #HF2026 #TEER #MitralRegurgitation #GDMT #Cardiology
📚 Yoshida A. et al. European Journal of Heart Failure (2026) 28, 70–81
🧵 Why do loop diuretics stop working in acute heart failure? Dr. Ana Belen Mendez Fernandez breaks it down at #HeartFailure26
Diuretic resistance = mismatch between drug delivery & tubular response. 3 main culprits:
1️⃣ Impaired drug delivery
• Gut edema → poor oral absorption
• Reduced renal perfusion
• Hypoalbuminemia
2️⃣ Tubular adaptation (“braking phenomenon”)
• Distal nephron hypertrophy
• ↑ Na reabsorption distal to loop of Henle
3️⃣ Neurohormonal activation
• RAAS activation
• Sympathetic nervous system activation
Know the mechanism → pick the right counterstrategy 💡
#CardioTwitter #HeartFailure #Cardiology #Diuretics
Did you know? Paperpile now integrates with OpenEvidence. 💫
You can save papers directly from OpenEvidence to your Paperpile library with just one click using the browser extension.
"What drives me absolutely bonkers is when a patient with new, severe left ventricular (LV) dysfunction comes in with soft blood pressure, evidence of low perfusion, and volume overload, and doctors start a beta-blocker. This is totally wrong." @drjohnm
https://t.co/kHjgZHT1sP
Evidencia emergente orienta a replantear el dogma histórico, y continuar explorando la utilización de cloruro de sodio para descongestionar de manera más segura y eficiente.
Así es, sal para quitar sal 💁🏻♂️
JAMA Cardiology 2026
10.1001/jamacardio.2026.0938
After TAVI, invasively measured transvalvular gradients—but not echocardiography-derived gradients— were associated with mortality up to 2 years. Echocardiography systematically overestimated gradients, particularly with balloon-expandable valves. Read more in our #EIJBestOf 👇
#CardioTwitter #TAVI
🔗https://t.co/Nb5dAvZLpB
@RikAdrMD@verhemel@Rjnuis@JoostDaemen@drnvanmieghem
Diuretic Resistance Risk and the Efficacy of Natriuresis-Guided Diuretic Therapy in Acute Heart Failure: Post Hoc Analysis From the PUSH-AHF Trial | JACC: Heart Failure https://t.co/UAiquEY2hF
Use of the preCARDIA system in patients with ADHF was feasible and well tolerated, with early exploratory signals of significantly reduced cardiac filling pressures and increased urine output. https://t.co/TOzTeRD2DX
#JACCHF#HeartFailure@RAYANYOUX