Chris Cotsapas

Genetics, genomics, immunity, data analysis. All opinions belong to whoever spoke last to me.

[Chris Cotsapas @ccots]

Today I join @VesaliusTx as SVP Data Science. Our mission is to make progress in drug discovery for common disease. I’m excited to translate human genetics and genomics into action!

[Chris Cotsapas @ccots]

We are hiring a data maven for @cotsapaslab - please spread the word :) https://t.co/nMSHE1fpMR

[Chris Cotsapas @ccots]

@StatGenDan I no longer bother re-formatting to journal style for a first submission, except bibs and any resources tables if mandatory. It either doesn’t matter or will be rearranged by the reviewers anyway.

[Chris Cotsapas @ccots]

@neilfws ETA: I have gradually realized that volume of data does not necessarily correlate to *useful/relevant* information content

[Chris Cotsapas @ccots]

@neilfws Yes?

[Chris Cotsapas @ccots]

@alexisjbattle Cringe comedy?

[Chris Cotsapas @ccots]

In other news, we have an opening for an experienced comp bio maven @cotsapaslab. Come work - and grow - with us! https://t.co/nMSHE1fpMR

[Chris Cotsapas @ccots]

@bvoight28 I now target 6/year (down from 10-12), in addition to AE duties @PLOSGenetics. For review I select for "important" or "I want to read in-depth" (otherwise I'd skim the pre-print and pretend I read it)

[Chris Cotsapas @ccots]

@ceclindgren @cristenw @pnatarajanmd @ScienceMagazine @markmccarthyoxf @moderna_tx +1 @cristenw that EBV has been floated as causal for ages. Key for me here is that EBV infection seems to precede NfL serum levels - implies no(t much) neuronal damage before infection. I'd say it's a trigger rather "causal" - but also https://t.co/oFmgnE4iXW

[Chris Cotsapas @ccots]

@LaLilli11 Open the PDF you've downloaded for at least 5 minutes...

[Chris Cotsapas @ccots]

Do you read papers regularly? Contextually (writing grants/papers etc)? Rarely (who has the time)? I've gone from regular to rare over the last 10y and I'd like to change...

[Chris Cotsapas @ccots]

@alexisjbattle @Y_Gilad @yluo86 @LB_Barreiro Went into this looking for a benchmark. Rather shocked at yield. I too suspect context (e.g. @kauralasoo enhancer priming) - but we do need to be thoughtful about current results, and about speculating w/out data. I'd also like to stop writing negative papers

[Chris Cotsapas @ccots]

@SerenaTucci Yep. And not just new PIs... If you notice the older folks appearing nonchalant, that's just PTSD

[Chris Cotsapas @ccots]

@strnr I loved Ancillary Justice by Anne Leckie (first of three), and Gideon the Ninth by Tamsin Muir (also first of three). Both space operas, which aren't really my jam but these are great!

[Chris Cotsapas @ccots]

@WuTsaiYale postdoc fellowship now available to work on neuroticism genetics/genomics with @kristenbrennand and me at @Yale - apply by Aug 15th! https://t.co/rw69ZZ7eQc

[Chris Cotsapas @ccots]

@ceclindgren I like notability too - it's the only solution I've found that allows me to import an image and doodle on it to annotate. Still working out how to integrate with Bear (my main notes app) - don't want to ditch that one...

[Chris Cotsapas @ccots]

@tuuliel If youngest lab members cannot distiguish between you and colleagues 1/2 generations older, you're middle aged (or non-specifically old).

[Chris Cotsapas @ccots]

After close to a decade of wrangling, our cross-disease paper is finally done! https://t.co/jXcPXZT4P8

[Ben Jacobs @ben_m_jacobs]

1/ Great to get this out there: we used mendelian randomisation to show that BMI during childhood and low vitamin D are causal risk factors for multiple sclerosis. Free to read here: https://t.co/AiuYuZzQtS

[Chris Cotsapas @ccots]

@PaulFlicek They probably didn’t have 20 hours of conference calls each a week 🤮