Chun-Chen Jerry Yao

BSc '20 @mitbrainandcog @eboyden3 @insitubiology
Post-bacc @WeizmannScience PhD student @MCB_Harvard @nickpolizzi_
Protein evolution | Language learner | 🇹🇼

[Woody Ahern @woodyahern]

New enzymes can unlock chemistry we never had access to before. Here, we introduce RFdiffusion2 (RFD2), a generative model that makes significant strides in de novo enzyme design.

Preprint: https://t.co/cAWGkrSxBo
Code: coming soon
Animation credit: https://t.co/Th9ZjsYeX2
(1/n)

[Chun-Chen Jerry Yao @ccyaoevo]

@haiqi_chen @genome_gov @NICHD_NIH Wow!! Huge congrats Haiqi!

[Chun-Chen Jerry Yao @ccyaoevo]

Come join the group! 🦙

[Nick Polizzi @nickpolizzi_]

I’m looking for a postdoc who would like to work primarily in the wet lab while also learning a bit of computational protein design. Lots of exciting projects! Please reach out if interested!

[Daniel Goodwin @D_R_Goodwin]

We wanted solarpunk, instead we got monoclonal antibodies.
As people get back to work after SynBioBeta and Memorial Day, I want to provoke some thoughts about what we work on and why.
Let's make the most of bioengineering's potential in climatetech.
https://t.co/InTbmU7f1f

[Niklas @Steube_N]

Check out our latest paper @KaHochberg @mpi_marburg in fruitful collaboration w/ Marcus & Thomas @TUBerlin featuring blind chance as the leading architect for building a novel protein-protein interaction out now @NatureEcoEvo: https://t.co/pW1BuOr31m. 1/11🧵

[Nick Polizzi @nickpolizzi_]

I’m looking for a postdoc who wants to work with me and Andrew Kruse to design and characterize new protein sensors! If you’re interested or have any leads, let me know!

[David Ho @_david_ho_]

I showed my students this movie of how atmospheric CO₂ travels around the globe and you should see it too.

[Yehu Moran @YehuMoran]

Our review article about the #evolution of antiviral innate immunity in animals is available in @NatureEcoEvo.
Contrasting ancient roots and some very fast gains and losses.

https://t.co/DDNiJ2b842

[rcsb pdb 💉🧬💻🔬💊🌱🧠🦠 @buildmodels]

PDB Reaches a New Milestone: 200,000+ Entries
With this week’s update, the PDB contains more than 200,000 entries
https://t.co/8189YShf0D
@PDBeurope @PDBj_en @PDBj_ja

[NatureEcoEvo @NatureEcoEvo]

Remembering Alfred Russel Wallace, influential thinker on natural selection and biogeography: https://t.co/YO6sxBSCEb

January 8th 2023 marks the bicentenary of Wallace's birth.

#Wallace200

[The Cultural Tutor @culturaltutor]

Why do clocks move in that direction?!

(It's got nothing to do with time...)

[Katelyn Comeau Boulanger @Katelyn_Comeau]

Almost all of these resonate with me as a 2nd year student. Take care of yourself folks

[Andrew Ng @AndrewYNg]

1/Large language models like Galactica and ChatGPT can spout nonsense in a confident, authoritative tone. This overconfidence - which reflects the data they’re trained on - makes them more likely to mislead.

[Joseph Watson @_JosephWatson]

DALL-E’s amazing images are popping up all over the web. That software uses something called a diffusion model, which is trained to remove noise from static until a clear picture is formed.

Turns out diffusion models can design proteins too!

[Chun-Chen Jerry Yao @ccyaoevo]

Harvard students stand with Chinese people

#Harvard
#UrumqiFire
#ZeroCovidChina
#Freedom
#Democracy

[David Ho @_david_ho_]

What’s the best film about climate change?

[Nathan Law 羅冠聰 @nathanlawkc]

Students from the elite school Tsinghua University protested with Friedmann equation. I have no idea what this equation means, but it does not matter.
It's the pronunciation: it's similar to "free的man" (free man)—a spectacular and creative way to express, with intelligence.

[Gustaf Ahdritz @gahdritz]

Our preprint on OpenFold, our trainable reproduction of AlphaFold2, is finally up (https://t.co/3EoTzE3Xdb)! Since we open-sourced parameters in June, we've trained the model to high accuracy more than 50 times, on a variety of datasets. Here's what we learned (a lot) -> (1/19)

[Sergey Ovchinnikov @sokrypton]

@PatrikD @DeepMind @UWproteindesign @ebetica @proteinrosh One of the hopes of protein LMs was that they could potentially generalize into sequence space that is sparsely occupied (with little to no sequence homologs or neighbors, within a certain cutoff). An "orphan" is a sequence with no neighbors. But what cutoff to use? (1/5)

[Feng Zhang @zhangf]

We’re excited to report today in @nature the cryo-EM structure of the OMEGA family member IsrB in complex with ωRNA and target DNA. https://t.co/jwlPWHUr0J