Chen Ying

Biostatistician

[Jonathan Göke @JonathanGoeke]

Fantastic #longtrec meeting in Valencia, very happy to participate in the @nanopore workshop describing the recent updates in the cDNA protocol that doubles read length

Postdoc positions available @goekelab to work on long read RNA seq (and Bambu)!

https://t.co/SSB1cbLaP6

[Computational Transcriptomics @goekelab]

New in Bambu-Pipe: batch effect correction now integrated into clustering for long-read single-cell & spatial RNA-seq

When merging samples sequenced on different platforms (ONT vs PacBio) or with different kits (10x 3' vs 5'), cells tend to cluster by platform or chemistry due to technical variation in sequencing and library preparation rather than actual biological differences between cells.

Batch effect correction aligns cells across these technical sources, removing platform and kit-driven variation while preserving real biological differences, so the integrated dataset clusters by biology, not by how or where it was sequenced.

More details and documentation: https://t.co/rD3dy3pgAn

[Computational Transcriptomics @goekelab]

🙌The 2nd Singapore RNA Salon is just 2 days away! We have a great lineup of talks from Early Career Researchers, snacks for networking and a *shuttle bus* to help transport attendees from NUS & A*STAR to NTU

Make sure to register to secure your spot (and receive the bus details!): https://t.co/lXS9dOo8Sn

[Jonathan Göke @JonathanGoeke]

The new long read cDNA kit by @nanopore is a major upgrade (and improvement!), substantially increasing read length, with a strong impact on transcript discovery and quantification. We @goekelab have tested this in the beta release, more updates soon #nanoporeconf

[Computational Transcriptomics @goekelab]

We are thrilled to release Bambu-pipe 🧬 – supercharge your transcriptomics discovery.

🚀 Speed. Scalability. Precision. Isoform-level insights from long-read single-cell & spatial RNA-seq.

🔗 https://t.co/Vmx9ffvA1p
📄 https://t.co/QSWyabjOMz

[Computational Transcriptomics @goekelab]

🎉 We did it! Our lab’s first Hackathon! Huge thanks to everyone who coded, laughed, and powered through with great energy. So proud of our team — can’t wait for the next one! 🚀💻
#LabHackathon

[Jonathan Göke @JonathanGoeke]

our first lab hackathon, lot's of updates and improvements coming to https://t.co/SSB1cbLIEE

[Mile Sikic @msikic]

Don’t miss this chance to hear the latest RNA updates and network with the RNA community in Singapore.

[A*STAR Genome Institute of Singapore (A*STAR GIS) @astar_gis]

RNA Salon Events 🧬

Join us for our first RNA Salon on February 12th, 2026, 4-6pm at the Genome Institute of Singapore.

The event will feature 3 talks from early career researchers, followed by a networking session where you can get to know your fellow RNA researchers over some snacks & drinks.

If you’re interested in presenting at future events, please don't hesitate to get in touch at [email protected] or [email protected].

For more information, please refer to https://t.co/sq5U07SmyM

For registration: https://t.co/FiMWQE9j5T

#Genomics #RNA

[Jonathan Göke @JonathanGoeke]

Join us this week for the RNA Salon at the Genome Institute of Singapore! Speakers from @boxiangliu
(NUS) Dahai Luo and @msikic labs. Thanks for support by @RNASociety

[A*STAR Genome Institute of Singapore (A*STAR GIS) @astar_gis]

🎉GIS researcher bags prestigious L’Oréal-UNESCO Fellowship for Women in Science award 🎉

Dr Liu Jinyue, Principal Investigator of the Laboratory of Single-cell Spatial Neuromics in A*STAR Genome Institute of Singapore, was recently presented with the L’Oréal-UNESCO Fellowship for Women in Science award 2025.

The award celebrates the achievements of distinguished women scientists by awarding them its prestigious L’Oréal-UNESCO Fellowship for Women in Science (FWIS). In recognition of their groundbreaking research efforts, the For Women in Science awards outstanding women scientists with grants annually to help fund their projects. Dr Liu’s project was on “Connecting the dots: an RNA technology to map the brain wiring diagram.”

With this project, Dr Liu aims to advance her research on brain wiring by developing an RNA-based technology to map the brain’s complex neural circuits, tracing how different brain cells connect and communicate. Using molecular barcoding paired with advanced imaging genomics and AI, she seeks to decode brain connectivity and how neural circuits change in conditions such as autism, dementia and mental health challenges — driving insights that could lead to earlier diagnosis, more targeted interventions and ultimately, healthier ageing for everyone.

Dr Liu sees the programme’s support as pivotal to pushing this frontier further — giving her team the resources and multidisciplinary expertise needed to refine and validate the technology, while advancing tools that could reveal how brain wiring is altered in neurological and psychiatric conditions. She hopes her work will not only help societies like Singapore better support ageing populations, but also foster greater awareness and acceptance of neurodiversity in our community.

Congratulations, Dr Liu Jinyue, for receiving this award.

#ASTAR
#GIS
#jinyueliu

[Jonathan Göke @JonathanGoeke]

The Asia RNA Club Symposium will be happening in Seoul Nov 3-5, bringing together RNA scientists from the Asia-Pacific region. Excellent speakers and a great opportunity to connect! Abstract submission by Sept 5 https://t.co/bovhcjE3YL

[A*STAR Genome Institute of Singapore (A*STAR GIS) @astar_gis]

🎉Calling All Scientists, Clinicians and Innovators! 🎉

Join us as we celebrate 25 years of genomic excellence at the #GIS25: Genome Innovation & Precision Medicine Conference, happening 11–12 September 2025 at Matrix Auditorium, Biopolis, Singapore!

🔬 Dive into the future of genomics with world-renowned speakers🌎— Narry Kim, Daniel MacArthur, Shi-Jie Chen, K Thangaraj, Ryan Lister, Karen Miga, Arnold Ou, Nikolaus Schultz, Leslie Beh, Koh Woon-Puay, @J_i_n_g_m_e_i Li, @boxiangliu, Jinyue Liu, Kristijan Ramadan, Patrick Tan, Yvonne Tay, Sunny Wong who will share the latest developments on:

🧬RNA/DNA Technologies
🔬Spatial & Single Cell Technologies
🤖Artificial Intelligence
🏥Population Health
🎯Precision Medicine

💡 Whether you're a researcher, clinician, or biotech innovator, this is your chance to connect, collaborate, and catalyze the next wave of breakthroughs!

👉 Sign up NOW to secure your spot: https://t.co/65VmgAvLKO

Let’s shape the future of genomics together. See you at #GIS25!

#GIS25 Scientific Committee: @ywan_wan, @waileongtam, KHOR Chiea Chuen, @shyam_lab, @msikic, @timoast, Jinyue Liu, Minghao Chia

[A*STAR Genome Institute of Singapore (A*STAR GIS) @astar_gis]

🎉GIS turns 25! Join us in celebrating 25 years of innovation at #GIS25: Genome Innovation and Precision Medicine Conference, happening 11–12 September at Matrix, Biopolis, Singapore!

🌍This milestone event will bring together global leaders in genomics research who will share the latest developments on:
🔬 RNA/DNA Technologies
🧬 Spatial & Single Cell Technologies
🤖 Artificial Intelligence
🏥 Population Health
🎯 Precision Medicine

✨Don’t miss this chance to:
✅ Hear from world-renowned speakers
✅ Dive into groundbreaking research
✅ Network with fellow scientists and innovators
✅ Spark collaborations that shape the future of healthcare

📅 Save the date and register now! Limited seats available!
👉 https://t.co/wXJnPx7FYh

#GIS25 #Genomics #PrecisionMedicine #BiomedicalInnovation

[A*STAR Genome Institute of Singapore (A*STAR GIS) @astar_gis]

🚀 Exciting News from Singapore! 🚀

Scientists at A*STAR's Genome Institute of Singapore (@astar_gis) have unveiled one of the world's largest long-read RNA sequencing datasets! 🌍🔬 This groundbreaking resource, known as SG-NEx, is set to revolutionize disease research by providing unprecedented insights into RNA complexity.

Key Highlights:
+ 750 million long RNA reads across 14 human cell lines
+ Enhanced detection of complex RNA features like cancer-related fusion transcripts
+ Freely accessible via the AWS Open Data Registry

This dataset will accelerate biomarker discovery and precision medicine, paving the way for next-gen diagnostics and therapies. Kudos to the team at A*STAR GIS - @JonathanGoeke, @chenying927, Andre Sim, Kristin Ma, Min Hao Ling, Nicolaï Hoffmann, Yuk Kei Wan! 👏🔬

Learn more: https://t.co/hhXG2TcFfD

#Genomics #PrecisionMedicine

[A*STAR Genome Institute of Singapore (A*STAR GIS) @astar_gis]

🎉 Exciting News! 🎉

We are thrilled to announce that Dr. Suphavilai Chayaporn has been awarded the GIS Innovation Fellow FY24! 🏆

Dr. Suphavilai is spearheading an innovative project at GIS, aiming to develop clinical-grade metagenomic diagnostic systems for effective infectious disease detection and management in healthcare settings. 🌟

Check out her 1-minute pitch 🎥of the project here: https://t.co/lA4E8UnGhQ

📧 Interested in collaborating with Dr. @nokcs and the team? Reach out to us at [email protected].

#Innovation #Healthcare #Metagenomics #InfectiousDiseases #Collaboration

[A*STAR Genome Institute of Singapore (A*STAR GIS) @astar_gis]

Congratulations to @JonathanGoeke, @chenying927 and our @astar_gis team on your SG-NEx project, providing a comprehensive resource that enables the development and benchmarking of computational methods for profiling complex transcriptional events at isoform-level resolution.

[Computational Transcriptomics @goekelab]

We are happy to share that our SG-NEx manuscript (led by @chenying927, @nadia_davidson, @yukkeiwan and @JonathanGoeke), is now out with open access: https://t.co/om90nZHvlb, together with an update release of SG-NEx data v0.6.0!

[Nature Methods @naturemethods]

This Analysis presents benchmarking results from the Singapore Nanopore Expression consortium project, including a valuable resource of datasets generated from various long-read and short-read RNA sequencing technologies.

https://t.co/zfoDNFfUAJ

[Jonathan Göke @JonathanGoeke]

We are recruiting! We have an open position for a postdoctoral fellow to join our team at the Genome Institute of Singapore @astar_gis to work with long read/direct RNA-Seq data. More details here: https://t.co/NalqRNIYZB