Chuck Lynch

Assistant Professor of Neuroscience in @WCMPsychiatry | Precision functional mapping, Neuromodulation, Mood disorders

[Chuck Lynch @cl9681]

🧠 We’re hiring!
Our lab at Weill Cornell is recruiting Research Assistants and Postdoctoral Fellows for BD²-funded projects studying mood dynamics in bipolar disorder w/ longitudinal precision fMRI and personalized TMS targeting.

📍 NYC | Full-time
🧵 Details below

[Nature Reviews Bioengineering @natrevbioeng]

Restoring vision and touch with cortical microstimulation https://t.co/u8RNu9SvRP

[Choong-Wan (Wani) Woo @choongwanwoo]

Pain biomarkers can't prove or disprove someone's pain, but that doesn't make them futile. My comment in Nat Neurosci argues for a pluralistic, bio-psycho-social approach: biomarkers as complementary channels, not replacements for patient voice. https://t.co/W6BfghvVN3

[Desmond Oathes 🧲🧠⚡️👨🏻‍💻 @DesmondOathes]

This week, please join us for a talk by @DiegoPizzagalli titled, "Translational and Cross-Species Approaches to Anhedonia: Implications for Treatment Development and Stratification." Wed, June 3, 1:30pm EST at the usual zoom link. DM your email if not on our list for the link.

[Ignacio Saez, PhD @IgnacioSaezPhD]

How does your brain filter out noise and focus enough to learn efficiently?

Our newest preprint uses intracranial recordings + computational modeling to explore how selective attention shapes learning and state representations in the human brain 🧠

https://t.co/5UdiULuAHR

1/🧵

[Imaging Neuroscience @ImagingNeurosci]

New paper in Imaging Neuroscience by Andrew N. Van, Nico U.F. Dosenbach, et al:

Frame-wise multi-echo distortion correction for superior functional MRI

https://t.co/1VNpk0HTFj

[Rui Xu @ruix_mit]

Is resting-state fMRI a good proxy for anatomy? Site-seeded rsFC only weakly correlated with es-fMRI connectivity (median r=0.20). Two sites in the same canonical resting-state network can have distinct anatomical connections. rsFC tracks co-fluctuated activity, not wiring. 12/n

[Rui Xu @ruix_mit]

New preprint: "Monosynaptic connections link functionally similar regions in human cortex." We use electrical stimulation + fMRI in epilepsy patients to map whole-brain monosynaptic connectivity at 42 cortical sites. https://t.co/rSSSVsMWCQ 1/n

[Hesheng Liu @hesheng3]

Lesion network mapping (LNM) has been powerful in linking symptoms and brain functional circuits, but ongoing debates highlight that it is still hard to isolate symptom-specific effects. We came up with a new method, robust LNM (rLNM) — a unified framework combining null models and selective specificity to reveal reliable, symptom-specific networks from background structure. https://t.co/6WHpBRNuQn
@bttyeo @foxmdphd @ndosenbach @club_scan

[Chuck Lynch @cl9681]

Great work by @zach_ladwig @GrattonCaterina

[Neuron @NeuroCellPress]

Online now: Precision fMRI reveals densely interdigitated network patches with conserved motifs in the lateral prefrontal cortex https://t.co/WqL1ZNEWpH

[Martin Hebart @martin_hebart]

I'm proud we are releasing LAION-fMRI, a densely sampled 7T fMRI dataset of natural images, with very broad stimulus sampling for testing countless hypotheses & deeply exploring brain representations. It is now available at
https://t.co/hOnILHonf9
What does LAION-fMRI offer? 🧵

[Martin Hebart @martin_hebart]

Finally, today is the day: Josefine Zerbe will present and release our new multi-echo 7T fMRI dataset LAION-fMRI during #VSS2026, with >30 fMRI session per subject and unprecedented stimulus diversity. Come to Talk Room 1 (Scene perception) today at 5:15. Details after the talk!

[ApertureNeuro @ApertureOHBM]

Do longer scans really improve prediction and reduce costs in BWAS?

Explore the commentary series:
• Breakspear: https://t.co/KQARlXBzB8
• Bijsterbosch: https://t.co/ZreDRpjxJp
• McIntosh: https://t.co/AaNi0STcZu

[Chuck Lynch @cl9681]

🧠 How can personalized brain imaging help advance more targeted treatments for #BipolarDisorder?

Excited to share more about our work with @BD2Discoveries. Our team at @WeillCornell (@immanuel_elbau, Lindsay Victoria, @amykooz), in collaboration with @StanfordMed (Cammie Rolle, @DrCoreyKeller), is using individualized brain imaging to better understand brain circuits involved in mood regulation and to inform more precise stimulation-based interventions.

Grateful to be part of this broader effort to move toward more personalized approaches to bipolar disorder care.

[BD² @BD2Discoveries]

A move toward precision psychiatry: Charles Lynch, PhD and his BD² Discovery team at @WeillCornell, in collaboration with @StanfordMed, are using personalized brain imaging to tailor targeted interventions for #bipolardisorder.

[thmonk @thmonk_pf]

TMSの抗うつメカニズム

mouse optogenetics aiTBS (Accelerated intermittent θ Burst Stimulation)modelでIT投射neuron特異的synapse可塑性と前頭-島皮質回路がaiTBSの抗うつ効果の必要十分条件である

ヒトiEEG/fMRIで島皮質の役割を直接検証

#TMS
#depression
#papers
https://t.co/zIA5fvPOuu

[Anders Martin Fjell @AndersFjell]

Use of brain age models frequently lead to wrong conclusions - unfortunately it is not easy to fix. Fortunately, there are better alternatives. @LCBC_UiO @Edvardosg @fmrib_steve @VidalDidac @KWalhovd @max12elliott https://t.co/HMdPjSkuO8

[Brain Stimulation @brainstimj]

New in Brain Stimulation: Real-time E-field neuronavigation on realistic head models for conventional & multi-locus TMS!

Ana M. Soto et al. present a robust framework accounting for cortical folding.

Full text: https://t.co/6d4ctgufNk

#TMS #Neuroscience #BrainStimulation

[BD² @BD2Discoveries]

📊BD² data release: the largest multi‑modal psychiatric dataset. Built across 6 sites with shared standards—aligned protocols, defined data practices & rigorous QA—so it’s ready to power new questions and collaborations. 🔗 https://t.co/oiKLJhDVKV

[Nicholas Branigan @NKBranigan]

I’m excited to share this work from an amazing team @StanfordBrain: @mystrypercy who co-led the study, Zhiyao Gao, Weidong Cai, and Vinod Menon.

https://t.co/k9yMTldiBr [2/12]

[Nico Dosenbach @ndosenbach]

Association cortex connected to the striatum (esp. PFC) is more chained (catenated) than parietal regions belonging to the DMN (e.g. angular gyrus) and context-association network (CAN), with FC to the hippocampus. Why? what's the processing difference?
https://t.co/V7PQ5DtPK1

[Nico Dosenbach @ndosenbach]

Function & cytoarchitecture don't overlap ... they're orthogonal. Prefrontal cortex is tiled with chains of functional patches mostly known from face processing. Multi-modal parcellations are wrong ... & other insights hidden by group-averaging fMRI data: https://t.co/WEo2Cf9N26