Claudio de Lucia, M.D., Ph.D.

Geriatrician & Physician-Scientist #AslNapoli1 | #Aging 👵🏻👴🏼 & #Dementia 🧠 | Tweets r my own

[Claudio de Lucia, M.D., Ph.D. @cladelucia]

✅ Check our latest Editorial on “Metabolomics, heart disease and aging” in @AgingJrnl 🔬🫀👴🏼👵🏻
Link: https://t.co/I6nOPoAY0w
#aging #heartdisease #metabolomics #metabolism #geriatrics #heart #cardiotwitter #Cardiovascular #Editorial #MedTwitter #research #medicina #medicine

[Nicholas Fabiano, MD @NTFabiano]

COVID-19 can cause brain cells to fuse.

🧵1/9

[Adam Grant @AdamMGrant]

Machines have surpassed humans in empathy.

New evidence: AI beat humans in detecting emotions and giving support. As long as people didn't know AI created the messages, they felt more heard.

It's not that AI is so good. It's that we often fail to use our emotional intelligence.

[Adam Grant @AdamMGrant]

A mark of emotional maturity is hearing disagreement without taking offense.

Thoughtful dissent doesn't always mean you're wrong. It often means the issue is complex and your knowledge is incomplete.

Good-faith debate isn't an attack. It's an opportunity to sharpen your ideas.

[Adam Grant @AdamMGrant]

Self-doubt stops too many women from applying for jobs.

After clearing the bar for expert-level work, 92% of men applied—but only 50% of women did.

It shouldn't matter whether you feel qualified. That's for the employer to judge. If you're interested, put your hat in the ring.

[Adam Grant @AdamMGrant]

Confidence doesn't always come from believing in yourself today. It often stems from recalling the obstacles you overcame yesterday.

A history of resilience can silence self-doubt. Challenges conquered are clues to hidden strengths.

Past progress is proof of future potential.

[htw @heniek_htw]

Effect of #Circadian Rhythm and #Menstrual Cycle on #Physical Performance in #Women: A Systematic Review
https://t.co/jWhJxrifXj

[Adam Grant @AdamMGrant]

In disagreements, earning respect is not about being right. It's about being reasonable.

8 studies: considering multiple interests and practical solutions signals morality and rationality, opening dialogue across divides.

A key to building bridges is balanced pragmatism.

[Shibley @dr_shibley]

Nursing homes are a place where delirium superimposed on dementia often occurs.
This year for #WDAD2024 I should like to discuss the fictional case of B.M. as an example of where this happened.
Important to spot it, prevent it and treat it.
https://t.co/J5x1iEd0mu

[Shibley @dr_shibley]

@GiusepeBellelli

[Adam Grant @AdamMGrant]

There's no such thing as an ideal daily routine. The best model is the one that works for you.

Successful people don't keep similar schedules. Their common practice is experimenting to learn what suits them.

Don't be a slave to others' habits. One size doesn't fit all minds.

[Adam Grant @AdamMGrant]

Claiming the moral high ground is rarely a sign of virtue. It’s often a signal of narcissism.

People who consistently believe they hold superior principles have inflated opinions of their own judgment.

Being self-righteous is a barrier to respecting and learning from others.

[Adam Grant @AdamMGrant]

A core skill of emotional intelligence is observing feelings before internalizing them.

Emotions are messages from your past self to your present self. They're best interpreted by your future self.

Feelings don't define who you are. They reveal what you value right now.

[Rob Wüst @RobWust]

After a long wait, our longitudinal long COVID study is finally published in @NatureComms: https://t.co/0xfTnjTPNB. We find a skeletal muscle alterations in patients with #longcovid, which worsen with exercise. 1/n

[Danielle Beckman, PhD @DaniBeckman]

For this #FluorescenceFriday, I want to share the first photo I took of microglia cells fusing each other. I have never seen this before; who did this? #HIV.

I have looked at brains under the microscope for many years now, but knowing that neurons and glial cells can fuse with each other is something I never learned during my Ph.D. We learn that most viruses don't even directly cause damage to the brain, and when they do, it is only because they killed their host cells. However, some chronic neurological sequelae of viral infections cannot be explained only by neural cell death.

It is known that in non-neuronal tissues, viruses fuse with host membranes to enter cells, hijacking the cellular machinery to produce viral components and sometimes conferring the ability to fuse with neighboring cells. This results in the formation of multinucleated cells, allowing viral propagation without needing virion release into the extracellular space.

Guess what? Viral-mediated fusion of brain cells also exists but still remains poorly understood.
The irreversible fusion of brain cells causes disruption in neuronal communication and reveals another possible mechanism to explain chronic neuronal malfunction even many years after the initial infection.

We now know that #SARSCoV2 can also cause brain cells to fuse, especially inducing neuron-neuron fusion. Instead of firing independently to propagate signals throughout the brain, fused neurons fire simultaneously, and this massive amount of synchronous activity is similar to seizure-like events. The desynchronized neuronal activity caused by fused neurons can also help explain symptoms like brain fog. When these events occur in the autonomic nervous system, for example, it can help explain dysautonomia, which so often happens with #LongCovid patients.

We must keep fighting against the concept that the brain is an isolated, immuno-privileged site.
Immune privilege, a term coined by the Nobel Prize winner Peter Medawar in the 1940s, holds that a few sites in the body, including the brain, do not show typical inflammatory responses, an evolutionary adaptation to protect these critical sites from potentially damaging inflammation. This could not be more far from the truth. Unfortunately, evolution did not give us this unique ability. This dogma has only served to bias the interpretation of our findings and slow the discovery of basic mechanisms induced by the presence of pathogens and potential therapies to counteract them.

[Adam Grant @AdamMGrant]

Time doesn't heal psychological wounds. Perspective does.

Days passed don't guarantee insight gained. Seeing last year's disappointments through an old lens is more upsetting than viewing yesterday's setbacks from a new angle.

Time creates distance. Reflection offers wisdom.

[Danielle Beckman, PhD @DaniBeckman]

Happy Wednesday with a zoom on some glial cells in the dentate granular cell layer of the Hippocampus! 🧠🔬 Markers: 🟣Nuclei (Dapi)🟢Microglia (Iba1)🟠Astrocytes (GFAP) @zeiss_micro #neuroscience

[Claudio de Lucia, M.D., Ph.D. @cladelucia]

Please ✅ our Review Article on the recent insights on “🧬Adrenergic signaling in cardiovascular🫀aging". 👵🏻
This manuscript is the result of a long-lasting collaboration with my amazing friend @IoannisKy !
Enjoy, comment and feel free to share the news !
https://t.co/DSmM8gxxcP

[Adam Grant @AdamMGrant]

Young kids have wider circles of concern than adults.

Adults expect people to enjoy the misfortune of groups they dislike. But 3-5-year-olds expect people to care about everyone's suffering.

Compassion is an instinct—we don't have to learn it. We need to stop unlearning it.

[Diego Segura-Rodríguez @SeguraCardio]

📌Mechanisms of benefits of #SGLT2i in #HeartFailure with preserved ejection fraction

#cardiotwitter #cardioEd #Review #SGLT2 #HFpEF

[🇳🇴🇩🇰Asbjørn Støylen 🇬🇱🇵🇸🇺🇦 @strain_rate]

Atrial contractile strain, reflects ventricular expansion during atrial systole, and is a function of atrial contractility, ventricular compliance (Numerator), and atrial size (denominator). Plenty of confounders. https://t.co/KTj7i4iZjM