Cole Bracken

Antibody engineer and chemical biologist | Ph.D. from @UCSF in @realJimWells lab

[Cole Bracken @cole_bracken]

New single domain antibody dropping july 3 - excited to share our work using display technologies to develop novel biologics that allosterically inhibit enpp1 (led by the fearless and twitterless Paige Solomon)

[Nature Chemical Biology @nchembio]

A new paper from @realJimWells generated variable heavy single-domain antibodies that bind and allosterically inhibit ENNP1 1 to increase the half-life of the immune-stimulant cGAMP in tumor microenvironments. Open access.

[Cole Bracken @cole_bracken]

Congrats Paul! It's finally out!

[Paul Klauser @PaulKlauser]

Proud to share our latest work developing a covalent nanobody radiopharmaceutical in @ACSCentSci ! https://t.co/X9SN7TfnIZ

[Caleb Lareau @CalebLareau]

Out today in @NatureProtocols, our detailed writeup on the mitochondrial scATAC-seq assay, spanning everything from the molecular biology to computational analyses. Check out the paper here: https://t.co/b1Jx57UKAe and some highlights in this thread: (1/11)

[Arun Wiita @apwiita]

Fantastic meeting for the @RWJF Harold Amos Minority Faculty Development Award. Proud to mentor Emilio Ramos as he discovers new immunotherapy targets for rare #AML subtypes, and totally blown away by the accomplishments of all the trainees in this program! #humbling

[Nick Polizzi @nickpolizzi_]

My group at @HMS_BCMP and @DFCI_ChemBio is looking for a new postdoc with an interest in developing deep learning algorithms for ligand-binding protein design. Can start immediately. DM or email me if interested!

[Kevin Parker @krparker]

Excited to announce @CartographyBio's launch to bring precision immunotherapies to patients - precise therapies start with precise antigens

[Cartography Biosciences @CartographyBio]

We’re excited to officially launch Cartography Biosciences today with $57M in initial financing. With this support, we will create a smarter roadmap for #cancer immunotherapies with our precision antigen expression atlas. 🧵

#Oncology #MedTwitter

https://t.co/gXYfV2py4R

[Arun Wiita @apwiita]

Our latest now out @NatureComms! We use cell surface #proteomics to find new #immunotherapy targets and biomarkers of resistance in #myeloma #mssm. Resource + we identify CCR10 as target & develop natural ligand CAR-Ts. Huge effort led by @idferguson
https://t.co/Ytl1LASMs3

[Paul Klauser @PaulKlauser]

Happy to share our latest work genetically encoding a new unnatural amino acid, meta-fluorosulfate-L-tyrosine (mFSY), published in @ChemCommun !
https://t.co/17EDD9G1QR

[Irene Chen @irenechen_png]

One of the most rewarding experiences in my graduate career. Postponing 2021 holidays were worth it! 🥹

[Nick Polizzi @nickpolizzi_]

Made a lab website! https://t.co/8ouLtUgT20
Recruiting postdocs, techs, and grad students to join the group this summer/fall in Boston. See the Join pg on the site for details!

[Cole Bracken @cole_bracken]

@PaulKlauser @WangUCSF Congrats Paul!!

[Cole Bracken @cole_bracken]

It’s out! So stoked to have been involved with this cool tech! Congrats to all 👏

[Jamie Byrnes @jrbyrnes8]

Happy to report that earlier this week our study examining how immunosuppressive factors modulate the surface proteome (#surfaceome) of primary human T cells was published in @molcellprot! (1/5) https://t.co/3hGWrUODQi

[Nick Polizzi @nickpolizzi_]

Super excited to announce that I'm starting my lab in May @DanaFarber @DFCI_ChemBio and @harvardmed @HMS_BCMP as a TT asst prof! Couldn't dream of a better environment!

My lab will aim to learn the rules of protein molecular recognition through the lens of protein design.

1/n

[Cole Bracken @cole_bracken]

Great work from great labmates! ���

[Shion Lim @shionanlim]

My postdoctoral work is now published! https://t.co/MrupZum7yH
In this truly tag-team effort with @JieZhou55370495, we determined whether neo-epitopes generated by increased proteolytic activity in the tumor microenvironment can be selectively recognized by antibodies. (1 of 7)

[Arun Wiita @apwiita]

Great feature here from @MichelsonMedRF on the work of @k_mandal_88, discovering new conformation-specific surface antigens for immunotherapy targeting.
Stay tuned for Kamal's innovative work and thank you Michelson Foundation for supporting him!
https://t.co/k7bzkM3Kd0

[Cate Ward, PhD, RD @catepward]

Excited to finally have this published. Through measuring global translation rates and de novo lipogenesis in mice, we show that with tunicamycin induced UPR-ER lipids are mobilized from adipose to liver (and liver lipid synthesis is decreased).

https://t.co/eggiijYBfn

[Bryan Faust, PhD @Bryan__Faust]

Interested in #autoimmune diseases, #GPCR's and signaling biology? How #autoantibodies can mimic hormone functions? Check out our preprint where we describe such molecular mimicry in the pathogenesis of Graves' disease. https://t.co/q4CgRV3R9E (1/9)

[J. Am. Chem. Soc. @J_A_C_S]

✨ One of our most read articles in the last 12 months! ✨
Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1 by Cotton, Nguyen, Gramespacher, @IanSeiple & @realJimWells 
🔓 #OpenAccess https://t.co/k3gtcsSWUV