Paul George Edassery

Electrical Engineer
Umich EECS '22, SNU '18

[Nischith Shadagopan M N @findingnische]

anyone can be @RickRubin now

[Tanishq Mathew Abraham, Ph.D. @iScienceLuvr]

Cancer patients with the same diagnosis often have very different tumor biology.

Molecular testing can reveal underlying differences, but that's slow and expensive.

Introducing Holon-S1, our platform to predict genes and biomarkers from routine pathology slides.

• beats two other models at predicting spatial gene activity in a controlled comparison
• has identified potentially novel biomarkers in breast cancer and colon cancer
• evaluated across 16 organ types and more than 15 scanners, using slides from both formalin-fixed, paraffin-embedded and fresh-frozen tissue.

We believe Holon-S1 has the potential to help researchers find new biomarkers in slides they already have, discover treatment targets, and bring more personalized cancer care within reach!

[i²cjak @i2cjak]

literally had a dream that I found, randomly, 64GB of DDR5 in my house

[Paul George Edassery @commandpaul]

@vulbsti @iScienceLuvr https://t.co/J51NekdPAJ you’ll also need to update your config cpu ram limits

[Paul George Edassery @commandpaul]

@vulbsti @iScienceLuvr Yeah WSL and linux native Claude code ( with remote control if you like the app ) may do it .

[Paul George Edassery @commandpaul]

Randomized controlled Math.

[Vinod Ganesan @vinodgansan]

With [redacted] we were able to do something which none anywhere has ever experienced imo. It was just magical.

Can’t wait to realise this fully and get it to everyone’s hands.

[Paul George Edassery @commandpaul]

I attended Prof Disseroth’s talk at AIIMS in 2016 his labs work using viruses to make synaptic channels sensitive to optical stimulation for functional interventions ++ their efforts to map brains, were absolutely illuminating.

https://t.co/F4kX8jZj0d

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”

[Internet Freedom Foundation (IFF) @internetfreedom]

Statement : The removal of BitChat from the India App Store is unconstitutional. Section 69A permits the blocking of unlawful information, not of a messenger for working during internet shutdowns.

New Delhi, 3 October 2026

An Apple App Review notice published today by Jack Dorsey on X records that BitChat has been removed from the India App Store "per demand from the Ministry of Electronics and Information Technology", issued under Section 69A of the Information Technology Act, 2000, on the ground that the application "includes content that is illegal in India". The notice adds that BitChat's TestFlight builds are no longer available for testing in India. It does not identify the content said to be illegal or the ground under Section 69A invoked. The blocking order has not been published. The Internet Freedom Foundation condemns the order and calls for its immediate publication and withdrawal.

BitChat relays end-to-end encrypted messages between nearby phones over Bluetooth mesh. It has no servers and hosts no content of its own. What travels through it is the private speech of its users, so the claim that the application "includes" illegal content is incoherent. The State's actual objection stands recorded in the notices the Indian Cyber Crime Coordination Centre issued on 23 July 2026 to GitHub, Google and Apple against BitChat, Briar and Bridgefy which stated that such applications work even during internet shutdowns and hamper lawful interception, attribution and traceability. Those notices, issued under Section 79(3)(b) were reportedly withdrawn after public disclosure. The same end has now been pursued through Section 69A. The objection is to capability of an application, not to content it transmits. A citizen's ability to speak to another citizen while the State has switched the internet off is not a ground of restriction under Section 69A or Article 19(2) of the Constitution.

Section 69A survived constitutional scrutiny in Shreya Singhal v. Union of India (2015) because of its safeguards which included the need for a reasoned, recorded order, committee review, and a hearing to the originator under Rule 8 of the Blocking Rules, 2009, which the Delhi High Court enforced in Tanul Thakur v. Union of India (2022). Further, Anuradha Bhasin v. Union of India (2020) requires that orders restricting fundamental rights be published and adopt the least restrictive measure. However, it appears in this instance, each safeguard has been evaded. A secret order blocking an entire application, rather than any identified unlawful information, is the most restrictive and disproprotionate measure available. Further, the confidentiality claimed under Rule 16 cannot defeat the right to challenge an order, and the constitutionality of this blocking regime is itself pending consideration before the Supreme Court.

While removal from the App Store does not delete BitChat from phones, it stops new downloads and security updates, leaving existing users on unpatched versions, and it ends security testing in India through TestFlight. During the Jantar Mantar protests, when mobile internet was suspended and jammers were deployed, Bluetooth mesh messaging was a channel of last resort through which young people coordinated their safety. To our knowledge, Apple has removed BitChat on a government's demand in only one other country. This is in China, in April this year.

Our demands

1. MeitY must publish the blocking order, the ground invoked and the record of the committee's proceedings, and serve the developers with a copy and an opportunity of hearing.

2. The direction must be withdrawn. Any specific unlawful use must be met with targeted proceedings under due process, not the removal of a communications tool for everyone.

3. Apple must disclose the demand in its transparency reporting and notify its users in India, and must state whether parallel directions have been received in respect of other app stores.

4. The secrecy of the blocking regime must end. The Blocking Rules, 2009 should be amended to require publication of orders and notice to originators, without awaiting the outcome of the pending constitutional challenge.

The Internet Freedom Foundation will file applications under the Right to Information Act seeking a copy of the order, and stands ready to assist the developers and affected users in India.

[jack @jack]

government of India officially removes bitchat from the App Store

[Paul George Edassery @commandpaul]

Looking for a next host platform offerring more P2P op support. Will miss 265KF Single thread perf 😢.

[Paul George Edassery @commandpaul]

Cooking w/ Claude: a Shakti RISC-V soft core on an AMD Alveo U200 FPGA runs Linux + NVIDIA's open driver, drives an RTX 5090's display and runs nvcc-built CUDA kernels via a C port of tinygrad's NV backend. The Intel host relays GPU access (no FPGA-GPU P2P on the 265KF).

[Vinod Ganesan @vinodgansan]

We gave @alma_inc a Zerodha account and asked her to trade on NIFTY50 options. Fully with computer-use.

Alma opened the terminal, read the NIFTY charts, analyzed the option chain, placed an order, and closed it in profit - all under 60 seconds.

Alma will be the most capable computer use product in the world, stay tuned!

[Paul George Edassery @commandpaul]

@Milan_Nair @kalamazooooo The exhaust does not look right , may be a mod

[Paul George Edassery @commandpaul]

@ptrschmdtnlsn Yeah killed one a few weeks ago, using BITSTREAM.CONFIG.OVERTEMPPOWERDOWN now and being mindful to check est TDP.

[Paul George Edassery @commandpaul]

@usr_bin_roygbiv @TechMDAI Tbf more memory bandwidth in 4 5090s

[Nischith Shadagopan M N @findingnische]

we gave gpt-6 astra and @alma_inc the same task: play krunker (a shooting game) and survive. fully using computer use.

astra wasn't even close to alma.

the last 20 seconds are pure chaos.

[Paul George Edassery @commandpaul]

@alma_inc @findingnische All tool assisted speed runs .

[Paul George Edassery @commandpaul]

@_markel___ CML

[Paul George Edassery @commandpaul]

@IanCutress Why XLS ?